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ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [ Homo sapiens (human) ]

Gene ID: 55616, updated on 7-Jun-2020

Summary

Official Symbol
ASAP3provided by HGNC
Official Full Name
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3provided by HGNC
Primary source
HGNC:HGNC:14987
See related
Ensembl:ENSG00000088280 MIM:616594
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACAP4; UPLC1; CENTB6; DDEFL1
Summary
This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Expression
Ubiquitous expression in ovary (RPKM 21.1), skin (RPKM 19.0) and 23 other tissues See more
Orthologs

Genomic context

See ASAP3 in Genome Data Viewer
Location:
1p36.12
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (23428563..23484631, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23755056..23810750, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ZNF436 antisense RNA 1 Neighboring gene zinc finger protein 436 Neighboring gene transcription elongation factor A3 Neighboring gene uncharacterized LOC101928163 Neighboring gene E2F transcription factor 2 Neighboring gene Sharpr-MPRA regulatory region 7496

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20199

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
ruffle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
Names
ARF6 GTPase-activating protein
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 1
centaurin, beta 6
development and differentiation enhancing factor-like 1
protein up-regulated in liver cancer 1
up-regulated in liver cancer 1 (UPLC1)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143778.2NP_001137250.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform b

    See identical proteins and their annotated locations for NP_001137250.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region and uses an alternate in-frame splice site compared to variant 1. The resulting protein (isoform b) is shorter compared to isoform a.
    Source sequence(s)
    AK000206, AK295100, AL021154, AL357134
    Consensus CDS
    CCDS44087.1
    UniProtKB/Swiss-Prot
    Q8TDY4
    Related
    ENSP00000408826.2, ENST00000437606.6
    Conserved Domains (7) summary
    cd07640
    Location:35234
    BAR_ASAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 3
    cd00204
    Location:581665
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:285391
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:298381
    PH; PH domain
    pfam01412
    Location:419534
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:599653
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:542575
    ANK; ANK repeat [structural motif]
  2. NM_017707.4NP_060177.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform a

    See identical proteins and their annotated locations for NP_060177.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AB056749, AK000206, AL021154, AL357134
    Consensus CDS
    CCDS235.1
    UniProtKB/Swiss-Prot
    Q8TDY4
    UniProtKB/TrEMBL
    A0A024RAB1
    Related
    ENSP00000338769.3, ENST00000336689.8
    Conserved Domains (7) summary
    cd07640
    Location:35243
    BAR_ASAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 3
    cd00204
    Location:590674
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:294400
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:307390
    PH; PH domain
    pfam01412
    Location:428543
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:608662
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:551584
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    23428563..23484631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001687.1XP_016857176.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X4

  2. XM_017001689.1XP_016857178.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X6

  3. XM_017001685.2XP_016857174.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X2

  4. XM_017001686.2XP_016857175.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X3

  5. XM_011541755.2XP_011540057.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1

    Conserved Domains (7) summary
    cd07640
    Location:35243
    BAR_ASAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 3
    cd00204
    Location:592676
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:296402
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:309392
    PH; PH domain
    pfam01412
    Location:430545
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:610664
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:553586
    ANK; ANK repeat [structural motif]
  6. XM_017001688.2XP_016857177.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X5

    UniProtKB/TrEMBL
    B4DRP2
    Conserved Domains (7) summary
    cd00204
    Location:459543
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:163269
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:176259
    PH; PH domain
    pfam01412
    Location:297412
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:477531
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:420453
    ANK; ANK repeat [structural motif]
    cl12013
    Location:1112
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_014040926.1 Reference GRCh38.p13 PATCHES

    Range
    198542..254158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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