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DDX60 DExD/H-box helicase 60 [ Homo sapiens (human) ]

Gene ID: 55601, updated on 9-Feb-2020

Summary

Official Symbol
DDX60provided by HGNC
Official Full Name
DExD/H-box helicase 60provided by HGNC
Primary source
HGNC:HGNC:25942
See related
Ensembl:ENSG00000137628 MIM:613974
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular procsses involving RNA binding and alteration of RNA secondary structure. This gene encodes a DEXD/H box RNA helicase that functions as an antiviral factor and promotes RIG-I-like receptor-mediated signaling. [provided by RefSeq, Apr 2017]
Expression
Ubiquitous expression in stomach (RPKM 14.0), colon (RPKM 7.7) and 24 other tissues See more
Orthologs

Genomic context

See DDX60 in Genome Data Viewer
Location:
4q32.3
Exon count:
44
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (168216293..168325981, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (169137442..169239958, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377523 Neighboring gene annexin A10 Neighboring gene uncharacterized LOC105377524 Neighboring gene DExD/H-box 60 like Neighboring gene uncharacterized LOC107986198 Neighboring gene palladin, cytoskeletal associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates the gene expression of DDX60 in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10787, FLJ20035

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MDA-5 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of RIG-I signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DDX60
Names
ATP-dependent RNA helicase DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DEAD box protein 60
DEAD-box helicase 60
NP_060101.3
XP_011530405.1
XP_011530406.1
XP_016863872.1
XP_016863873.1
XP_024309900.1
XP_024309901.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054636.1 RefSeqGene

    Range
    5056..107514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017631.6NP_060101.3  probable ATP-dependent RNA helicase DDX60

    See identical proteins and their annotated locations for NP_060101.3

    Status: REVIEWED

    Source sequence(s)
    AK001649, AK307404, BC020601, BC038115, BC074781
    Consensus CDS
    CCDS34097.1
    UniProtKB/Swiss-Prot
    Q8IY21
    UniProtKB/TrEMBL
    Q6B0F7, Q9H616, Q9NXV7
    Related
    ENSP00000377344.3, ENST00000393743.8
    Conserved Domains (1) summary
    cl28230
    Location:7621373
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    168216293..168325981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454132.1XP_024309900.1  probable ATP-dependent RNA helicase DDX60 isoform X1

    Conserved Domains (1) summary
    cl28230
    Location:7621373
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
  2. XM_024454133.1XP_024309901.1  probable ATP-dependent RNA helicase DDX60 isoform X1

    Conserved Domains (1) summary
    cl28230
    Location:7621373
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
  3. XM_011532103.3XP_011530405.1  probable ATP-dependent RNA helicase DDX60 isoform X2

    Conserved Domains (2) summary
    smart00490
    Location:12541330
    HELICc; helicase superfamily c-terminal domain
    pfam00270
    Location:768922
    DEAD; DEAD/DEAH box helicase
  4. XM_011532104.3XP_011530406.1  probable ATP-dependent RNA helicase DDX60 isoform X3

    Conserved Domains (1) summary
    pfam00270
    Location:768922
    DEAD; DEAD/DEAH box helicase
  5. XM_017008384.1XP_016863873.1  probable ATP-dependent RNA helicase DDX60 isoform X5

  6. XM_017008383.1XP_016863872.1  probable ATP-dependent RNA helicase DDX60 isoform X4

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