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ITLN1 intelectin 1 [ Homo sapiens (human) ]

Gene ID: 55600, updated on 8-Jul-2018
Official Symbol
ITLN1provided by HGNC
Official Full Name
intelectin 1provided by HGNC
Primary source
HGNC:HGNC:18259
See related
Ensembl:ENSG00000179914 MIM:609873; Vega:OTTHUMG00000028604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HL1; LFR; HL-1; INTL; ITLN; hIntL; omentin
Expression
Biased expression in colon (RPKM 361.8), small intestine (RPKM 202.0) and 3 other tissues See more
Orthologs
See ITLN1 in Genome Data Viewer
Location:
1q23.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (160876540..160885170, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (160846330..160854960, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 9 Neighboring gene CD244 molecule Neighboring gene spermine synthase pseudogene Neighboring gene uncharacterized LOC101928372 Neighboring gene intelectin 2

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
  • Antimicrobial peptides, organism-specific biosystem (from REACTOME)
    Antimicrobial peptides, organism-specific biosystemAntimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum of antimicrobial activity against bacteria, viruses, and fungi (Zasloff M 2002; Radek K & Gallo R 2007). The majo...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20022

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
oligosaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
antimicrobial humoral response TAS
Traceable Author Statement
more info
 
positive regulation of glucose import IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein homotrimerization IDA
Inferred from Direct Assay
more info
PubMed 
response to nematode ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
brush border membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
intelectin-1
Names
ITLN-1
endothelial lectin HL-1
galactofuranose-binding lectin
intelectin 1 (galactofuranose binding)
intestinal lactoferrin receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017625.2NP_060095.2  intelectin-1 precursor

    See identical proteins and their annotated locations for NP_060095.2

    Status: VALIDATED

    Source sequence(s)
    BC020664
    Consensus CDS
    CCDS1211.1
    UniProtKB/Swiss-Prot
    Q8WWA0
    Related
    ENSP00000323587.3, OTTHUMP00000027882, ENST00000326245.3, OTTHUMT00000071462
    Conserved Domains (1) summary
    cl00085
    Location:3782
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    160876540..160885170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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