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OTUD5 OTU deubiquitinase 5 [ Homo sapiens (human) ]

Gene ID: 55593, updated on 24-Nov-2020

Summary

Official Symbol
OTUD5provided by HGNC
Official Full Name
OTU deubiquitinase 5provided by HGNC
Primary source
HGNC:HGNC:25402
See related
Ensembl:ENSG00000068308 MIM:300713
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUBA
Summary
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in brain (RPKM 16.1), spleen (RPKM 14.4) and 25 other tissues See more
Orthologs

Genomic context

See OTUD5 in Genome Data Viewer
Location:
Xp11.23
Exon count:
13
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (48922024..48960783, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48779301..48815880, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member A2 Neighboring gene Pim-2 proto-oncogene, serine/threonine kinase Neighboring gene RNA, U6 small nuclear 722, pseudogene Neighboring gene potassium voltage-gated channel subfamily D member 1 Neighboring gene GRIP1 associated protein 1 Neighboring gene Sharpr-MPRA regulatory region 9113

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104871, DKFZp761A052

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Lys48-specific deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Lys63-specific deubiquitinase activity EXP
Inferred from Experiment
more info
PubMed 
Lys63-specific deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Lys63-specific deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
thiol-dependent ubiquitin-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitinyl hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of type I interferon production TAS
Traceable Author Statement
more info
 
protein K48-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
OTU domain-containing protein 5
Names
OTU domain containing 5
deubiquinating enzyme A
deubiquitinating enzyme A
NP_001129629.1
NP_001129630.1
NP_001129631.1
NP_060072.1
XP_005272679.1
XP_005278096.1
XP_005278099.1
XP_006724600.1
XP_011542234.1
XP_011542236.1
XP_016885117.1
XP_016885118.1
XP_016885119.1
XP_024308164.1
XP_024308165.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136157.2NP_001129629.1  OTU domain-containing protein 5 isoform b

    See identical proteins and their annotated locations for NP_001129629.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame portion of an internal coding exon, compared to variant 1, resulting in a shorter protein (isoform b) compared to isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AL137509, BC009917, BC028225, CB243128
    Consensus CDS
    CCDS48104.1
    UniProtKB/Swiss-Prot
    Q96G74
    Related
    ENSP00000365671.3, ENST00000376488.7
    Conserved Domains (1) summary
    cl19932
    Location:221330
    OTU; OTU-like cysteine protease
  2. NM_001136158.2NP_001129630.1  OTU domain-containing protein 5 isoform b

    See identical proteins and their annotated locations for NP_001129630.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and lacks an in-frame portion of an internal coding exon, compared to variant 1, resulting in a shorter protein compared to isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    BC009917, BC011738, BC028225, CB243128
    Consensus CDS
    CCDS48104.1
    UniProtKB/Swiss-Prot
    Q96G74
    Related
    ENSP00000379969.3, ENST00000396743.7
    Conserved Domains (1) summary
    cl19932
    Location:221330
    OTU; OTU-like cysteine protease
  3. NM_001136159.2NP_001129631.1  OTU domain-containing protein 5 isoform c

    See identical proteins and their annotated locations for NP_001129631.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK294590, CB243128, CN368451, DC419901
    Consensus CDS
    CCDS48105.1
    UniProtKB/Swiss-Prot
    Q96G74
    Related
    ENSP00000401629.2, ENST00000428668.2
    Conserved Domains (1) summary
    cl19932
    Location:4113
    OTU; OTU-like cysteine protease
  4. NM_017602.4NP_060072.1  OTU domain-containing protein 5 isoform a

    See identical proteins and their annotated locations for NP_060072.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC009917, CB243128
    Consensus CDS
    CCDS14313.1
    UniProtKB/Swiss-Prot
    Q96G74
    UniProtKB/TrEMBL
    A0A024QZ09
    Related
    ENSP00000156084.4, ENST00000156084.8
    Conserved Domains (1) summary
    cl19932
    Location:221335
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    48922024..48960783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272622.4XP_005272679.1  OTU domain-containing protein 5 isoform X3

    Conserved Domains (1) summary
    cl19932
    Location:221330
    OTU; OTU-like cysteine protease
  2. XM_006724537.3XP_006724600.1  OTU domain-containing protein 5 isoform X2

    See identical proteins and their annotated locations for XP_006724600.1

    UniProtKB/Swiss-Prot
    Q96G74
    UniProtKB/TrEMBL
    A0A024QZ09
    Conserved Domains (1) summary
    cl19932
    Location:221335
    OTU; OTU-like cysteine protease
  3. XM_005278039.4XP_005278096.1  OTU domain-containing protein 5 isoform X1

    See identical proteins and their annotated locations for XP_005278096.1

    Conserved Domains (1) summary
    cl19932
    Location:221335
    OTU; OTU-like cysteine protease
  4. XM_011543932.2XP_011542234.1  OTU domain-containing protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011542234.1

    Conserved Domains (1) summary
    cl19932
    Location:221335
    OTU; OTU-like cysteine protease
  5. XM_017029630.1XP_016885119.1  OTU domain-containing protein 5 isoform X5

  6. XM_005278042.4XP_005278099.1  OTU domain-containing protein 5 isoform X4

    See identical proteins and their annotated locations for XP_005278099.1

    Conserved Domains (1) summary
    cl19932
    Location:4118
    OTU; OTU-like cysteine protease
  7. XM_024452396.1XP_024308164.1  OTU domain-containing protein 5 isoform X6

    Conserved Domains (1) summary
    cl19932
    Location:4113
    OTU; OTU-like cysteine protease
  8. XM_017029629.1XP_016885118.1  OTU domain-containing protein 5 isoform X4

    Conserved Domains (1) summary
    cl19932
    Location:4118
    OTU; OTU-like cysteine protease
  9. XM_011543934.2XP_011542236.1  OTU domain-containing protein 5 isoform X8

    Conserved Domains (1) summary
    cl19932
    Location:297
    OTU; OTU-like cysteine protease
  10. XM_017029628.2XP_016885117.1  OTU domain-containing protein 5 isoform X3

    Conserved Domains (1) summary
    cl19932
    Location:221330
    OTU; OTU-like cysteine protease
  11. XM_024452397.1XP_024308165.1  OTU domain-containing protein 5 isoform X7

    Conserved Domains (1) summary
    cl19932
    Location:4113
    OTU; OTU-like cysteine protease
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