Format

Send to:

Choose Destination

BMP2K BMP2 inducible kinase [ Homo sapiens (human) ]

Gene ID: 55589, updated on 3-May-2020

Summary

Official Symbol
BMP2Kprovided by HGNC
Official Full Name
BMP2 inducible kinaseprovided by HGNC
Primary source
HGNC:HGNC:18041
See related
Ensembl:ENSG00000138756 MIM:617648
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIKE; HRIHFB2017
Summary
This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 10.8), lymph node (RPKM 10.8) and 25 other tissues See more
Orthologs

Genomic context

See BMP2K in Genome Data Viewer
Location:
4q21.21
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (78776350..78916365)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (79697532..79837519)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928893 Neighboring gene CRISPRi-validated cis-regulatory element chr4.1979 Neighboring gene uncharacterized LOC105377299 Neighboring gene ribosomal protein S21 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 10702 Neighboring gene RNA, 7SL, cytoplasmic 127, pseudogene Neighboring gene progestin and adipoQ receptor family member 3 Neighboring gene long intergenic non-protein coding RNA 1088 Neighboring gene N-alpha-acetyltransferase 11, NatA catalytic subunit Neighboring gene uncharacterized LOC105377300

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of BMP2 inducible kinase (BMP2K) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434K0614, DKFZp434P0116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AP-2 adaptor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
positive regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of bone mineralization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
BMP-2-inducible protein kinase
NP_060063.2
NP_942595.1
XP_005263174.1
XP_011530404.1
XP_016863870.1
XP_016863871.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047162.1 RefSeqGene

    Range
    5001..140810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017593.4NP_060063.2  BMP-2-inducible protein kinase isoform b

    See identical proteins and their annotated locations for NP_060063.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC098818, AK075278, AL137661, BC036021
    Consensus CDS
    CCDS34019.1
    UniProtKB/Swiss-Prot
    Q9NSY1
    Related
    ENSP00000421768.1, ENST00000502871.5
    Conserved Domains (2) summary
    smart00220
    Location:52311
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:47320
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
  2. NM_198892.1NP_942595.1  BMP-2-inducible protein kinase isoform a

    See identical proteins and their annotated locations for NP_942595.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL137275, AL137661
    Consensus CDS
    CCDS47083.1
    UniProtKB/Swiss-Prot
    Q9NSY1
    Related
    ENSP00000334836.5, ENST00000335016.9
    Conserved Domains (3) summary
    smart00220
    Location:52311
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:47320
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:8931161
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    78776350..78916365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263117.1XP_005263174.1  BMP-2-inducible protein kinase isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:52311
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:47320
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:8561124
    BMP2K_C; BMP-2-inducible protein kinase C-terminus
  2. XM_011532102.1XP_011530404.1  BMP-2-inducible protein kinase isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:52311
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:47320
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
  3. XM_017008381.1XP_016863870.1  BMP-2-inducible protein kinase isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:13231
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:1240
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:8131081
    BMP2K_C; BMP-2-inducible protein kinase C-terminus
  4. XM_017008382.1XP_016863871.1  BMP-2-inducible protein kinase isoform X3

    Related
    ENSP00000424668.1, ENST00000502613.1
Support Center