Format

Send to:

Choose Destination

UBE2Q1 ubiquitin conjugating enzyme E2 Q1 [ Homo sapiens (human) ]

Gene ID: 55585, updated on 19-Jul-2021

Summary

Official Symbol
UBE2Q1provided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Q1provided by HGNC
Primary source
HGNC:HGNC:15698
See related
Ensembl:ENSG00000160714 MIM:617429
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTAP; NICE5; UBE2Q; NICE-5; PRO3094
Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is 98% identical to the mouse counterpart. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 25.0), lymph node (RPKM 18.1) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See UBE2Q1 in Genome Data Viewer
Location:
1q21.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (154548577..154558662, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154521053..154531138, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, non-ATPase, 8 pseudogene 1 Neighboring gene interleukin 6 receptor Neighboring gene Src homology 2 domain containing E Neighboring gene tudor domain containing 10 Neighboring gene UBE2Q1 antisense RNA 1 Neighboring gene uncharacterized LOC107985206 Neighboring gene cholinergic receptor nicotinic beta 2 subunit Neighboring gene adenosine deaminase RNA specific

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in embryo implantation IEA
Inferred from Electronic Annotation
more info
 
involved_in fertilization IEA
Inferred from Electronic Annotation
more info
 
involved_in mating behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in prolactin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in reproductive system development IEA
Inferred from Electronic Annotation
more info
 
involved_in suckling behavior IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in filopodium IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 Q1
Names
E2 ubiquitin-conjugating enzyme Q1
galactosyl transferase-associated protein
protein NICE-5
ubiquitin carrier protein Q1
ubiquitin conjugating enzyme E2Q family member 1
ubiquitin-conjugating enzyme E2Q (putative) 1
ubiquitin-protein ligase Q1
NP_060052.3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017582.7NP_060052.3  ubiquitin-conjugating enzyme E2 Q1

    See identical proteins and their annotated locations for NP_060052.3

    Status: REVIEWED

    Source sequence(s)
    AL592078, AY112698, CA391436
    Consensus CDS
    CCDS1069.1
    UniProtKB/Swiss-Prot
    Q7Z7E8
    Related
    ENSP00000292211.4, ENST00000292211.5
    Conserved Domains (1) summary
    cl00154
    Location:253409
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    154548577..154558662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center