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KIF27 kinesin family member 27 [ Homo sapiens (human) ]

Gene ID: 55582, updated on 25-Nov-2021

Summary

Official Symbol
KIF27provided by HGNC
Official Full Name
kinesin family member 27provided by HGNC
Primary source
HGNC:HGNC:18632
See related
Ensembl:ENSG00000165115 MIM:611253
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the KIF27 (kinesin 4) sub-family of the mammalian kinesin family. The gene is an ortholog of the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk domain containing a predicted coiled coil motif and a C-terminal tail domain. Alternatively spliced transcript variants have been observed for this gene. Pseudogenes associated with this gene are located on chromosome 9. [provided by RefSeq, Dec 2012]
Expression
Broad expression in testis (RPKM 7.5), thyroid (RPKM 3.1) and 21 other tissues See more
Orthologs
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Genomic context

See KIF27 in Genome Data Viewer
Location:
9q21.32
Exon count:
25
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (83832795..83921544, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (86449014..86536347, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ubiquilin 1 Neighboring gene UBQLN1 antisense RNA 1 Neighboring gene G kinase anchoring protein 1 Neighboring gene uncharacterized LOC101927552 Neighboring gene serine/arginine repetitive matrix protein 1-like Neighboring gene chromosome 9 open reading frame 64 Neighboring gene heterogeneous nuclear ribonucleoprotein K Neighboring gene microRNA 7-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • RP11-575L7.3, DKFZp434D0917

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in epithelial cilium movement involved in extracellular fluid movement IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ventricular system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271927.3NP_001258856.1  kinesin-like protein KIF27 isoform B

    See identical proteins and their annotated locations for NP_001258856.1

    Status: REVIEWED

    Source sequence(s)
    AL354733, AY237537, DC376766
    Consensus CDS
    CCDS65071.1
    UniProtKB/Swiss-Prot
    Q86VH2
    Related
    ENSP00000401688.1, ENST00000413982.5
    Conserved Domains (2) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  2. NM_001271928.3NP_001258857.1  kinesin-like protein KIF27 isoform C

    See identical proteins and their annotated locations for NP_001258857.1

    Status: REVIEWED

    Source sequence(s)
    AL354733, AY237538, DC376766
    Consensus CDS
    CCDS65072.1
    UniProtKB/Swiss-Prot
    Q86VH2
    Related
    ENSP00000333928.2, ENST00000334204.6
    Conserved Domains (5) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1340
    Location:8171100
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:800886
    DUF4200; Domain of unknown function (DUF4200)
    cl12013
    Location:713859
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  3. NM_001354069.2NP_001340998.1  kinesin-like protein KIF27 isoform D

    Status: REVIEWED

    Source sequence(s)
    AL354733
    Conserved Domains (2) summary
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    cl25732
    Location:7211098
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_001354070.2NP_001340999.1  kinesin-like protein KIF27 isoform E

    Status: REVIEWED

    Source sequence(s)
    AL354733
    Conserved Domains (1) summary
    cl25732
    Location:241603
    SMC_N; RecF/RecN/SMC N terminal domain
  5. NM_001354071.2NP_001341000.1  kinesin-like protein KIF27 isoform F

    Status: REVIEWED

    Source sequence(s)
    AL354733
    Conserved Domains (1) summary
    cl25732
    Location:241550
    SMC_N; RecF/RecN/SMC N terminal domain
  6. NM_017576.4NP_060046.1  kinesin-like protein KIF27 isoform A

    See identical proteins and their annotated locations for NP_060046.1

    Status: REVIEWED

    Source sequence(s)
    AL354733, AY237536, DC376766
    Consensus CDS
    CCDS6665.1
    UniProtKB/Swiss-Prot
    Q86VH2
    Related
    ENSP00000297814.2, ENST00000297814.7
    Conserved Domains (3) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:800884
    DUF4200; Domain of unknown function (DUF4200)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    83832795..83921544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014916.1XP_016870405.1  kinesin-like protein KIF27 isoform X16

    Conserved Domains (1) summary
    COG1196
    Location:112474
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  2. XM_017014900.1XP_016870389.1  kinesin-like protein KIF27 isoform X1

    Conserved Domains (4) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1340
    Location:8201077
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:826910
    DUF4200; Domain of unknown function (DUF4200)
  3. XM_017014904.1XP_016870393.1  kinesin-like protein KIF27 isoform X2

    UniProtKB/Swiss-Prot
    Q86VH2
    Conserved Domains (3) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:800884
    DUF4200; Domain of unknown function (DUF4200)
  4. XM_011518849.2XP_011517151.1  kinesin-like protein KIF27 isoform X1

    See identical proteins and their annotated locations for XP_011517151.1

    Conserved Domains (4) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1340
    Location:8201077
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:826910
    DUF4200; Domain of unknown function (DUF4200)
  5. XM_011518848.3XP_011517150.1  kinesin-like protein KIF27 isoform X1

    See identical proteins and their annotated locations for XP_011517150.1

    Conserved Domains (4) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1340
    Location:8201077
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:826910
    DUF4200; Domain of unknown function (DUF4200)
  6. XM_024447609.1XP_024303377.1  kinesin-like protein KIF27 isoform X13

    Conserved Domains (1) summary
    cl25732
    Location:267629
    SMC_N; RecF/RecN/SMC N terminal domain
  7. XM_024447610.1XP_024303378.1  kinesin-like protein KIF27 isoform X14

    Conserved Domains (1) summary
    cl25732
    Location:241603
    SMC_N; RecF/RecN/SMC N terminal domain
  8. XM_017014912.2XP_016870401.1  kinesin-like protein KIF27 isoform X14

    Conserved Domains (1) summary
    cl25732
    Location:241603
    SMC_N; RecF/RecN/SMC N terminal domain
  9. XM_011518850.2XP_011517152.1  kinesin-like protein KIF27 isoform X1

    See identical proteins and their annotated locations for XP_011517152.1

    Conserved Domains (4) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1340
    Location:8201077
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:826910
    DUF4200; Domain of unknown function (DUF4200)
  10. XM_011518857.2XP_011517159.1  kinesin-like protein KIF27 isoform X11

    Conserved Domains (2) summary
    COG1196
    Location:389751
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:604912
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  11. XM_017014902.1XP_016870391.1  kinesin-like protein KIF27 isoform X1

    Conserved Domains (4) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1340
    Location:8201077
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:826910
    DUF4200; Domain of unknown function (DUF4200)
  12. XM_017014907.1XP_016870396.1  kinesin-like protein KIF27 isoform X5

    UniProtKB/Swiss-Prot
    Q86VH2
    Conserved Domains (2) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  13. XM_017014908.1XP_016870397.1  kinesin-like protein KIF27 isoform X6

    UniProtKB/Swiss-Prot
    Q86VH2
    Conserved Domains (5) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1340
    Location:8171100
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:800886
    DUF4200; Domain of unknown function (DUF4200)
    cl12013
    Location:713859
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  14. XM_024447608.1XP_024303376.1  kinesin-like protein KIF27 isoform X9

    Conserved Domains (2) summary
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    cl25732
    Location:7211098
    SMC_N; RecF/RecN/SMC N terminal domain
  15. XM_017014903.1XP_016870392.1  kinesin-like protein KIF27 isoform X2

    UniProtKB/Swiss-Prot
    Q86VH2
    Conserved Domains (3) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:800884
    DUF4200; Domain of unknown function (DUF4200)
  16. XM_017014905.1XP_016870394.1  kinesin-like protein KIF27 isoform X3

    Conserved Domains (3) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1340
    Location:8741157
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  17. XM_011518854.2XP_011517156.1  kinesin-like protein KIF27 isoform X7

    Conserved Domains (5) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1842
    Location:779997
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:826910
    DUF4200; Domain of unknown function (DUF4200)
    cl12013
    Location:739885
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  18. XM_017014906.1XP_016870395.1  kinesin-like protein KIF27 isoform X4

    Conserved Domains (3) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:826910
    DUF4200; Domain of unknown function (DUF4200)
  19. XM_017014901.2XP_016870390.1  kinesin-like protein KIF27 isoform X1

    Conserved Domains (4) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1340
    Location:8201077
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:826910
    DUF4200; Domain of unknown function (DUF4200)
  20. XM_017014911.2XP_016870400.1  kinesin-like protein KIF27 isoform X12

  21. XM_017014909.1XP_016870398.1  kinesin-like protein KIF27 isoform X8

  22. XM_011518856.2XP_011517158.1  kinesin-like protein KIF27 isoform X10

    Conserved Domains (4) summary
    smart00129
    Location:5348
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1340
    Location:8201077
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:826910
    DUF4200; Domain of unknown function (DUF4200)
  23. XM_017014914.2XP_016870403.1  kinesin-like protein KIF27 isoform X15

RNA

  1. XR_002956796.1 RNA Sequence

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