ucp2 uncoupling protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ucp2provided by ZNC
Official Full Name: uncoupling protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-990708-8
See related: Ensembl:ENSDARG00000043154 AllianceGenome:ZFIN:ZDB-GENE-990708-8
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb74
Summary: Predicted to enable oxidative phosphorylation uncoupler activity. Predicted to be involved in adaptive thermogenesis; mitochondrial transmembrane transport; and response to cold. Predicted to act upstream of or within transmembrane transport. Predicted to be located in mitochondrial inner membrane. Is expressed in several structures, including blood; brain; cardiovascular system; pleuroperitoneal region; and ventral mesoderm. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal disease; metabolic dysfunction-associated steatotic liver disease; and obesity. Orthologous to human UCP2 (uncoupling protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (36662695..36673377)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (36718915..36729619)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

except for reduced lipid peroxidation, we did not observe any significant reactive oxygen species reduction associated with increased Ucp2 activation in cold-exposed group.
Title: Upregulation of uncoupling protein Ucp2 through acute cold exposure increases post-thaw sperm quality in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidative phosphorylation uncoupler activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adaptive thermogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cold	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dicarboxylate carrier UCP2

Names: UCP 2; mitochondrial uncoupling protein 2; solute carrier family 25 member 8; zUCP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131176.1 → NP_571251.1 dicarboxylate carrier UCP2

See identical proteins and their annotated locations for NP_571251.1

Status: PROVISIONAL

Source sequence(s)

BC065607

UniProtKB/Swiss-Prot

Q9W720

UniProtKB/TrEMBL

Q6P0I3, Q6PH29

Related

ENSDARP00000063358.5, ENSDART00000063359.7

Conserved Domains (2) summary

PTZ00169
Location:17 → 300

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:113 → 209

Mito_carr; Mitochondrial carrier protein