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GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 [ Homo sapiens (human) ]

Gene ID: 55568, updated on 7-Dec-2018

Summary

Official Symbol
GALNT10provided by HGNC
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 10provided by HGNC
Primary source
HGNC:HGNC:19873
See related
Ensembl:ENSG00000164574 MIM:608043
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GALNACT10; PPGALNACT10; PPGANTASE10
Summary
This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.[provided by RefSeq, Apr 2010]
Expression
Ubiquitous expression in ovary (RPKM 33.6), gall bladder (RPKM 12.6) and 23 other tissues See more
Orthologs

Genomic context

See GALNT10 in Genome Data Viewer
Location:
5q33.2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (154190735..154420984)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (153570295..153800544)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 114 member A2 Neighboring gene microfibril associated protein 3 Neighboring gene uncharacterized LOC107986465 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 7 Neighboring gene RNA, 7SL, cytoplasmic 655, pseudogene Neighboring gene microRNA 1294 Neighboring gene SAP30L antisense RNA 1 (head to head) Neighboring gene SAP30 like Neighboring gene heart and neural crest derivatives expressed 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of behavioral disinhibition.
NHGRI GWA Catalog
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
NHGRI GWA Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genome-wide association of BMI in African Americans.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MFAP3

Homology

Clone Names

  • FLJ00205, FLJ11715, DKFZp586H0623

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
polypeptide N-acetylgalactosaminyltransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
O-glycan processing IDA
Inferred from Direct Assay
more info
PubMed 
O-glycan processing TAS
Traceable Author Statement
more info
 
protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
polypeptide N-acetylgalactosaminyltransferase 10
Names
GalNAc transferase 10
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
NP_938080.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198321.4NP_938080.1  polypeptide N-acetylgalactosaminyltransferase 10

    See identical proteins and their annotated locations for NP_938080.1

    Status: REVIEWED

    Source sequence(s)
    AC008625, AC010295, AJ505950, BC050333, BQ549377
    Consensus CDS
    CCDS4325.1
    UniProtKB/Swiss-Prot
    Q86SR1
    Related
    ENSP00000297107.6, ENST00000297107.10
    Conserved Domains (4) summary
    cd02510
    Location:148443
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG1216
    Location:145449
    GT2; Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism]
    cd00161
    Location:461589
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:459587
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    154190735..154420984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017540.3: Suppressed sequence

    Description
    NM_017540.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_024564.1: Suppressed sequence

    Description
    NM_024564.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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