U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

bmpr2b bone morphogenetic protein receptor, type II b (serine/threonine kinase) [ Danio rerio (zebrafish) ]

Gene ID: 555655, updated on 9-Sep-2025
Official Symbol
bmpr2bprovided by ZNC
Official Full Name
bone morphogenetic protein receptor, type II b (serine/threonine kinase)provided by ZNC
Primary source
ZFIN:ZDB-GENE-070618-2
See related
Ensembl:ENSDARG00000020057 AllianceGenome:ZFIN:ZDB-GENE-070618-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Enables transforming growth factor beta receptor activity. Acts upstream of or within several processes, including BMP signaling pathway; circulatory system development; and fin regeneration. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including blood island; cardiovascular system; gonad; gut; and posterior pronephric duct. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease 1. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See bmpr2b in Genome Data Viewer
Location:
chromosome: 9
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 9 NC_133184.1 (13105407..13256868)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 9 NC_007120.7 (12959760..13111163)

Chromosome 9 - NC_133184.1Genomic Context describing neighboring genes Neighboring gene si:ch211-167j6.3 Neighboring gene si:dkey-230p4.1 Neighboring gene high choriolytic enzyme 2-like 1 Neighboring gene family with sequence similarity 117 member Bb Neighboring gene uncharacterized LOC141376080 Neighboring gene calcium responsive transcription factor

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Endothelial tip-cell position, filopodia formation and biomechanics require BMPR2 expression and signaling. Hiepen C, et al. Commun Biol, 2025 Jan 8. PMID 39779836, Free PMC Article
  2. Protection role of resveratrol against alcohol-induced heart defect in zebrafish embryos. Wang F, et al. Chin Med J (Engl), 2019 Apr 20. PMID 30958444, Free PMC Article
  3. Inhibition of Pi4kb activity causes malformation of vestibular apparatus in zebrafish by downregulating hey1. Feng Y, et al. Gene, 2024 Mar 10. PMID 38135256
  4. Alk3/Alk3b and Smad5 mediate BMP signaling during lymphatic development in zebrafish. Kim JD, et al. Mol Cells, 2014 Mar. PMID 24608800, Free PMC Article
  5. Disrupting Amh and androgen signaling reveals their distinct roles in zebrafish gonadal differentiation and gametogenesis. Wu K, et al. Commun Biol, 2025 Mar 5. PMID 40044757, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. bmpr2b mediates BMP signaling and is required to establish left-right asymmetry.
    Title: Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables BMP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transforming growth factor beta receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transforming growth factor beta receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in blood vessel development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within determination of left/right symmetry IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fin regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart jogging IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lung development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lymph vessel development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within notochord morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of locomotion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of lung blood pressure IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of multicellular organismal development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in tissue development IEA
Inferred from Electronic Annotation
more info
  
involved_in vasculature development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
bone morphogenetic protein receptor type-2
Names
bone morphogenetic protein receptor type II b
NP_001034896.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039807.1 → NP_001034896.1  bone morphogenetic protein receptor type-2 precursor

    See identical proteins and their annotated locations for NP_001034896.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ002899
    UniProtKB/TrEMBL
    Q288P2
    Related
    ENSDARP00000106831.2, ENSDART00000125961.3
    Conserved Domains (3) summary
    smart00220
    Location:217 → 503
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14054
    Location:217 → 512
    STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors
    pfam01064
    Location:58 → 137
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133184.1 Reference GRCz12tu Primary Assembly

    Range
    13105407..13256868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous