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ZNF821 zinc finger protein 821 [ Homo sapiens (human) ]

Gene ID: 55565, updated on 3-Oct-2020

Summary

Official Symbol
ZNF821provided by HGNC
Official Full Name
zinc finger protein 821provided by HGNC
Primary source
HGNC:HGNC:28043
See related
Ensembl:ENSG00000102984
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat (STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Expression
Broad expression in testis (RPKM 7.7), brain (RPKM 2.9) and 23 other tissues See more
Orthologs

Genomic context

See ZNF821 in Genome Data Viewer
Location:
16q22.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (71859680..71885353, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (71893583..71918093, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 13 pseudogene Neighboring gene ataxin 1 like Neighboring gene IST1 factor associated with ESCRT-III Neighboring gene polycystin 1 like 3, transient receptor potential channel interacting Neighboring gene ribosomal protein L39 pseudogene 31

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16350

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201552.2NP_001188481.1  zinc finger protein 821 isoform 1

    See identical proteins and their annotated locations for NP_001188481.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK296603, AK313693, BC004563, DA324992
    Consensus CDS
    CCDS56006.1
    UniProtKB/Swiss-Prot
    O75541
    Related
    ENSP00000398089.1, ENST00000425432.6
    Conserved Domains (4) summary
    sd00017
    Location:120140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:150172
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:289354
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:242382
    DUF460; Protein of unknown function (DUF460)
  2. NM_001201553.1NP_001188482.1  zinc finger protein 821 isoform 1

    See identical proteins and their annotated locations for NP_001188482.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC009127, AK296603, BC004563
    Consensus CDS
    CCDS56006.1
    UniProtKB/Swiss-Prot
    O75541
    Related
    ENSP00000455648.1, ENST00000565601.5
    Conserved Domains (4) summary
    sd00017
    Location:120140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:150172
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:289354
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:242382
    DUF460; Protein of unknown function (DUF460)
  3. NM_001201554.1NP_001188483.1  zinc finger protein 821 isoform 2

    See identical proteins and their annotated locations for NP_001188483.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    BC004563, BC012116, BC091492, DA324992
    Consensus CDS
    CCDS32481.1
    UniProtKB/Swiss-Prot
    O75541
    UniProtKB/TrEMBL
    A0A0C4DH12
    Related
    ENSP00000313822.6, ENST00000313565.10
    Conserved Domains (3) summary
    sd00017
    Location:7898
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07946
    Location:247312
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:200340
    DUF460; Protein of unknown function (DUF460)
  4. NM_001201556.1NP_001188485.1  zinc finger protein 821 isoform 3

    See identical proteins and their annotated locations for NP_001188485.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AK296603, AK313693, AL538838, BC004563, BC091492, DA324992
    Consensus CDS
    CCDS73911.1
    UniProtKB/Swiss-Prot
    O75541
    UniProtKB/TrEMBL
    A0A087WXX1
    Related
    ENSP00000481362.1, ENST00000611294.4
  5. NM_001318238.2NP_001305167.1  zinc finger protein 821 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (4), which is shorter than isoform 1.
    Source sequence(s)
    AC009127, BC004563, BC091492
    Conserved Domains (3) summary
    sd00017
    Location:222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07946
    Location:143204
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:92232
    DUF460; Protein of unknown function (DUF460)
  6. NM_001318239.2NP_001305168.1  zinc finger protein 821 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (4), which is shorter than isoform 1.
    Source sequence(s)
    BC091492
    Conserved Domains (3) summary
    sd00017
    Location:222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07946
    Location:143204
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:92232
    DUF460; Protein of unknown function (DUF460)
  7. NM_001376297.1NP_001363226.1  zinc finger protein 821 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009127, AC010653
    Conserved Domains (4) summary
    sd00017
    Location:120140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:150172
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:289354
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:242382
    DUF460; Protein of unknown function (DUF460)
  8. NM_001376298.1NP_001363227.1  zinc finger protein 821 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009127, AC010653
    Related
    ENSP00000456563.1, ENST00000568666.5
    Conserved Domains (4) summary
    sd00017
    Location:120140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:150172
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:289354
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:242382
    DUF460; Protein of unknown function (DUF460)
  9. NM_001376299.1NP_001363228.1  zinc finger protein 821 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009127, AC010653
    Conserved Domains (4) summary
    sd00017
    Location:120140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:150172
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:289354
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:242382
    DUF460; Protein of unknown function (DUF460)
  10. NM_001376300.1NP_001363229.1  zinc finger protein 821 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009127, AC010653
    Conserved Domains (3) summary
    sd00017
    Location:7898
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07946
    Location:247312
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:200340
    DUF460; Protein of unknown function (DUF460)
  11. NM_017530.2NP_060000.1  zinc finger protein 821 isoform 2

    See identical proteins and their annotated locations for NP_060000.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AF070588, AK296603, BC004563
    Consensus CDS
    CCDS32481.1
    UniProtKB/Swiss-Prot
    O75541
    UniProtKB/TrEMBL
    A0A0C4DH12
    Related
    ENSP00000405908.2, ENST00000446827.6
    Conserved Domains (3) summary
    sd00017
    Location:7898
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07946
    Location:247312
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:200340
    DUF460; Protein of unknown function (DUF460)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    71859680..71885353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023411.1XP_016878900.1  zinc finger protein 821 isoform X1

    UniProtKB/Swiss-Prot
    O75541
    Conserved Domains (4) summary
    sd00017
    Location:120140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:150172
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:289354
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:242382
    DUF460; Protein of unknown function (DUF460)
  2. XM_017023410.2XP_016878899.1  zinc finger protein 821 isoform X1

    UniProtKB/Swiss-Prot
    O75541
    Conserved Domains (4) summary
    sd00017
    Location:120140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:150172
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:289354
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:242382
    DUF460; Protein of unknown function (DUF460)
  3. XM_024450339.1XP_024306107.1  zinc finger protein 821 isoform X6

    Conserved Domains (1) summary
    pfam07946
    Location:90151
    DUF1682; Protein of unknown function (DUF1682)
  4. XM_017023417.2XP_016878906.1  zinc finger protein 821 isoform X5

    Conserved Domains (3) summary
    sd00017
    Location:222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07946
    Location:143204
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:92232
    DUF460; Protein of unknown function (DUF460)
  5. XM_017023413.2XP_016878902.1  zinc finger protein 821 isoform X3

  6. XM_011523212.3XP_011521514.1  zinc finger protein 821 isoform X2

    Conserved Domains (2) summary
    PHA02586
    Location:294355
    68; prohead core protein; Provisional
    sd00017
    Location:120140
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_017023419.1XP_016878908.1  zinc finger protein 821 isoform X5

    Conserved Domains (3) summary
    sd00017
    Location:222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07946
    Location:143204
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:92232
    DUF460; Protein of unknown function (DUF460)
  8. XM_017023416.1XP_016878905.1  zinc finger protein 821 isoform X5

    Conserved Domains (3) summary
    sd00017
    Location:222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07946
    Location:143204
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:92232
    DUF460; Protein of unknown function (DUF460)
  9. XM_017023423.1XP_016878912.1  zinc finger protein 821 isoform X6

    Conserved Domains (1) summary
    pfam07946
    Location:90151
    DUF1682; Protein of unknown function (DUF1682)
  10. XM_017023425.1XP_016878914.1  zinc finger protein 821 isoform X6

    Conserved Domains (1) summary
    pfam07946
    Location:90151
    DUF1682; Protein of unknown function (DUF1682)
  11. XM_024450341.1XP_024306109.1  zinc finger protein 821 isoform X6

    Conserved Domains (1) summary
    pfam07946
    Location:90151
    DUF1682; Protein of unknown function (DUF1682)
  12. XM_024450340.1XP_024306108.1  zinc finger protein 821 isoform X6

    Conserved Domains (1) summary
    pfam07946
    Location:90151
    DUF1682; Protein of unknown function (DUF1682)
  13. XM_017023421.1XP_016878910.1  zinc finger protein 821 isoform X5

    Conserved Domains (3) summary
    sd00017
    Location:222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07946
    Location:143204
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:92232
    DUF460; Protein of unknown function (DUF460)
  14. XM_017023420.1XP_016878909.1  zinc finger protein 821 isoform X5

    Conserved Domains (3) summary
    sd00017
    Location:222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07946
    Location:143204
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:92232
    DUF460; Protein of unknown function (DUF460)
  15. XM_017023412.1XP_016878901.1  zinc finger protein 821 isoform X1

    UniProtKB/Swiss-Prot
    O75541
    Conserved Domains (4) summary
    sd00017
    Location:120140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:150172
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:289354
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:242382
    DUF460; Protein of unknown function (DUF460)
  16. XM_017023415.2XP_016878904.1  zinc finger protein 821 isoform X5

    Conserved Domains (3) summary
    sd00017
    Location:222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07946
    Location:143204
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:92232
    DUF460; Protein of unknown function (DUF460)
  17. XM_017023424.2XP_016878913.1  zinc finger protein 821 isoform X6

    Conserved Domains (1) summary
    pfam07946
    Location:90151
    DUF1682; Protein of unknown function (DUF1682)
  18. XM_011523214.2XP_011521516.1  zinc finger protein 821 isoform X5

    See identical proteins and their annotated locations for XP_011521516.1

    Conserved Domains (3) summary
    sd00017
    Location:222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07946
    Location:143204
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:92232
    DUF460; Protein of unknown function (DUF460)
  19. XM_011523220.3XP_011521522.1  zinc finger protein 821 isoform X6

    See identical proteins and their annotated locations for XP_011521522.1

    Conserved Domains (1) summary
    pfam07946
    Location:90151
    DUF1682; Protein of unknown function (DUF1682)
  20. XM_017023418.1XP_016878907.1  zinc finger protein 821 isoform X5

    Conserved Domains (3) summary
    sd00017
    Location:222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07946
    Location:143204
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:92232
    DUF460; Protein of unknown function (DUF460)
  21. XM_011523211.3XP_011521513.1  zinc finger protein 821 isoform X1

    See identical proteins and their annotated locations for XP_011521513.1

    UniProtKB/Swiss-Prot
    O75541
    Conserved Domains (4) summary
    sd00017
    Location:120140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:150172
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:289354
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:242382
    DUF460; Protein of unknown function (DUF460)
  22. XM_017023422.1XP_016878911.1  zinc finger protein 821 isoform X5

    Conserved Domains (3) summary
    sd00017
    Location:222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07946
    Location:143204
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:92232
    DUF460; Protein of unknown function (DUF460)
  23. XM_024450342.1XP_024306110.1  zinc finger protein 821 isoform X5

    Conserved Domains (3) summary
    sd00017
    Location:222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07946
    Location:143204
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:92232
    DUF460; Protein of unknown function (DUF460)
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