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CDC42BPG CDC42 binding protein kinase gamma [ Homo sapiens (human) ]

Gene ID: 55561, updated on 11-Sep-2019

Summary

Official Symbol
CDC42BPGprovided by HGNC
Official Full Name
CDC42 binding protein kinase gammaprovided by HGNC
Primary source
HGNC:HGNC:29829
See related
Ensembl:ENSG00000171219 MIM:613991
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DMPK2; MRCKG; HSMDPKIN; KAPPA-200; MRCKgamma
Expression
Broad expression in skin (RPKM 11.8), stomach (RPKM 5.1) and 20 other tissues See more
Orthologs

Genomic context

See CDC42BPG in Genome Data Viewer
Location:
11q13.1
Exon count:
40
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (64823052..64844686, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64591661..64612041, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene menin 1 Neighboring gene Sharpr-MPRA regulatory region 8286 Neighboring gene EH domain containing 1 Neighboring gene microRNA 10392 Neighboring gene ribosomal protein S16 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton reorganization ISS
Inferred from Sequence or Structural Similarity
more info
 
actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule organizing center IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase MRCK gamma
Names
CDC42 binding protein kinase gamma (DMPK-like)
DMPK-like gamma
MRCK gamma
myotonic dystrophy kinase-related CDC42-binding kinase gamma
myotonic dystrophy protein kinase like protein
myotonic dystrophy protein kinase-like alpha
myotonic dystrophy protein kinase-like gamma
NP_059995.2
XP_011543457.1
XP_011543458.1
XP_011543459.1
XP_011543460.1
XP_011543461.1
XP_011543462.1
XP_011543463.1
XP_016873485.1
XP_016873486.1
XP_016873487.1
XP_016873488.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017525.3NP_059995.2  serine/threonine-protein kinase MRCK gamma

    See identical proteins and their annotated locations for NP_059995.2

    Status: VALIDATED

    Source sequence(s)
    AP001187, AY648038, BI793270
    Consensus CDS
    CCDS31601.1
    UniProtKB/Swiss-Prot
    Q6DT37
    Related
    ENSP00000345133.5, ENST00000342711.6
    Conserved Domains (7) summary
    pfam08826
    Location:744801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:9381070
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:879921
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:10971360
    CNH; CNH domain
    pfam13868
    Location:410802
    TPH; Trichohyalin-plectin-homology domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    64823052..64844686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545156.3XP_011543458.1  serine/threonine-protein kinase MRCK gamma isoform X3

    Conserved Domains (7) summary
    pfam08826
    Location:737794
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:9491081
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:890932
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11081371
    CNH; CNH domain
    pfam15558
    Location:422794
    DUF4659; Domain of unknown function (DUF4659)
  2. XM_011545158.3XP_011543460.1  serine/threonine-protein kinase MRCK gamma isoform X5

    Conserved Domains (7) summary
    pfam08826
    Location:744801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:9561088
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:897939
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13868
    Location:410802
    TPH; Trichohyalin-plectin-homology domain
    cl02434
    Location:11151340
    CNH; CNH domain
  3. XM_011545157.3XP_011543459.1  serine/threonine-protein kinase MRCK gamma isoform X4

    Conserved Domains (7) summary
    pfam08826
    Location:744801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:9561088
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:897939
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13868
    Location:410802
    TPH; Trichohyalin-plectin-homology domain
    cl02434
    Location:11151340
    CNH; CNH domain
  4. XM_017017996.2XP_016873485.1  serine/threonine-protein kinase MRCK gamma isoform X2

  5. XM_011545155.3XP_011543457.1  serine/threonine-protein kinase MRCK gamma isoform X1

    See identical proteins and their annotated locations for XP_011543457.1

    Conserved Domains (7) summary
    pfam08826
    Location:744801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:9561088
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:897939
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11151378
    CNH; CNH domain
    pfam13868
    Location:410802
    TPH; Trichohyalin-plectin-homology domain
  6. XM_011545160.3XP_011543462.1  serine/threonine-protein kinase MRCK gamma isoform X7

    Conserved Domains (8) summary
    pfam08826
    Location:646703
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:1239
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:858990
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:799841
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00169
    Location:870986
    PH; PH domain
    pfam00780
    Location:10171280
    CNH; CNH domain
    pfam13868
    Location:312704
    TPH; Trichohyalin-plectin-homology domain
  7. XM_017017999.1XP_016873488.1  serine/threonine-protein kinase MRCK gamma isoform X11

  8. XM_011545159.3XP_011543461.1  serine/threonine-protein kinase MRCK gamma isoform X6

    Conserved Domains (7) summary
    pfam08826
    Location:744801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:9561088
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:897939
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11151378
    CNH; CNH domain
    pfam13868
    Location:410802
    TPH; Trichohyalin-plectin-homology domain
  9. XM_017017998.2XP_016873487.1  serine/threonine-protein kinase MRCK gamma isoform X10

  10. XM_017017997.2XP_016873486.1  serine/threonine-protein kinase MRCK gamma isoform X8

  11. XM_011545161.3XP_011543463.1  serine/threonine-protein kinase MRCK gamma isoform X9

    Conserved Domains (5) summary
    pfam08826
    Location:744801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:9561088
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:897939
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RNA

  1. XR_949988.3 RNA Sequence

  2. XR_949989.3 RNA Sequence

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