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HAUS7 HAUS augmin like complex subunit 7 [ Homo sapiens (human) ]

Gene ID: 55559, updated on 1-Aug-2020

Summary

Official Symbol
HAUS7provided by HGNC
Official Full Name
HAUS augmin like complex subunit 7provided by HGNC
Primary source
HGNC:HGNC:32979
See related
Ensembl:ENSG00000213397 MIM:300540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UIP1; UCHL5IP
Summary
This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Expression
Ubiquitous expression in skin (RPKM 11.4), spleen (RPKM 5.8) and 24 other tissues See more
Orthologs

Genomic context

See HAUS7 in Genome Data Viewer
Location:
Xq28
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (153447665..153495465, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (152713123..152760983, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene PNMA family member 6E Neighboring gene ZFP92 zinc finger protein Neighboring gene three prime repair exonuclease 2 Neighboring gene Sharpr-MPRA regulatory region 9358 Neighboring gene extracellular matrix protein X-linked, pseudogene Neighboring gene extracellular matrix protein X-linked, pseudogene Neighboring gene biglycan Neighboring gene ATPase plasma membrane Ca2+ transporting 3 Neighboring gene cyclin Q

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TREX2

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thioesterase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
HAUS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
HAUS complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
HAUS augmin-like complex subunit 7
Names
26S proteasome-associated UCH37-interacting protein 1
UCHL5 interacting protein
X-linked protein STS1769

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012688.3 RefSeqGene

    Range
    29895..52861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001385481.1NP_001372410.1  HAUS augmin-like complex subunit 7 isoform 2

    Status: REVIEWED

    Source sequence(s)
    U82695
  2. NM_001385482.1NP_001372411.1  HAUS augmin-like complex subunit 7 isoform 1

    Status: REVIEWED

    Source sequence(s)
    U82695
    Consensus CDS
    CCDS35438.1
  3. NM_001385483.1NP_001372412.1  HAUS augmin-like complex subunit 7 isoform 2

    Status: REVIEWED

    Source sequence(s)
    U82695

RNA

  1. NR_073156.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains multiple differences, compared to variant 1, including use of an alternate upstream promoter. This variant is represented as non-coding because the use of the translational start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK125219, BC008141, DB248557, U82695
  2. NR_169630.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    U82695
  3. NR_169631.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    U82695

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    153447665..153495465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017518.7: Suppressed sequence

    Description
    NM_017518.7: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  2. NM_207106.2: Suppressed sequence

    Description
    NM_207106.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  3. NM_207107.2: Suppressed sequence

    Description
    NM_207107.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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