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PLXNA3 plexin A3 [ Homo sapiens (human) ]

Gene ID: 55558, updated on 22-Sep-2022

Summary

Official Symbol
PLXNA3provided by HGNC
Official Full Name
plexin A3provided by HGNC
Primary source
HGNC:HGNC:9101
See related
Ensembl:ENSG00000130827 MIM:300022; AllianceGenome:HGNC:9101
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
6.3; PLXN3; PLXN4; XAP-6; HSSEXGENE
Summary
This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in skin (RPKM 7.2), ovary (RPKM 7.2) and 25 other tissues See more
Orthologs
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Genomic context

See PLXNA3 in Genome Data Viewer
Location:
Xq28
Exon count:
34
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (154458281..154477779)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152694791..152714288)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153686621..153706118)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene GDP dissociation inhibitor 1 Neighboring gene family with sequence similarity 50 member A Neighboring gene microRNA 6858 Neighboring gene Sharpr-MPRA regulatory region 3405 Neighboring gene L antigen family member 3 Neighboring gene ubiquitin like 4A Neighboring gene solute carrier family 10 member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables semaphorin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables semaphorin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in axon extension involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in branchiomotor neuron axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in facial nerve structural organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hippocampus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of axon extension involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuron projection guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in olfactory nerve formation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within pyramidal neuron development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in semaphorin-plexin signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in semaphorin-plexin signaling pathway involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in semaphorin-plexin signaling pathway involved in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in trigeminal nerve structural organization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of semaphorin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of semaphorin receptor complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
plexin-A3
Names
Sex chromosome X transmembrane protein of HGF receptor family 3
plexin-4
semaphorin receptor SEX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021298.2 RefSeqGene

    Range
    5007..20372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017514.5NP_059984.3  plexin-A3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC244090, AW001914, BF798844, BG820285, BQ718472, BQ720233, CN427844, CN484803, HY098587, HY158513, X87852
    Consensus CDS
    CCDS14752.1
    UniProtKB/Swiss-Prot
    P51805, Q5HY36
    Related
    ENSP00000358696.3, ENST00000369682.4
    Conserved Domains (8) summary
    cd11273
    Location:21489
    Sema_plexin_A3; The Sema domain, a protein interacting module, of Plexin A3
    smart00423
    Location:788831
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00603
    Location:11251208
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:9351021
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:840934
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:10231123
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:490530
    PSI; Plexin repeat
    pfam08337
    Location:12941841
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    154458281..154477779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442247.1XP_047298203.1  plexin-A3 isoform X1

RNA

  1. XR_007068193.1 RNA Sequence

  2. XR_430556.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    152694791..152714288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)