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CDCA7L cell division cycle associated 7 like [ Homo sapiens (human) ]

Gene ID: 55536, updated on 24-Nov-2020

Summary

Official Symbol
CDCA7Lprovided by HGNC
Official Full Name
cell division cycle associated 7 likeprovided by HGNC
Primary source
HGNC:HGNC:30777
See related
Ensembl:ENSG00000164649 MIM:609685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
R1; JPO2; RAM2
Expression
Broad expression in thyroid (RPKM 17.0), bone marrow (RPKM 16.5) and 25 other tissues See more
Orthologs

Genomic context

See CDCA7L in Genome Data Viewer
Location:
7p15.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (21900899..21945899, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (21940517..21985542, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 11 Neighboring gene VISTA enhancer hs294 Neighboring gene uncharacterized LOC107986775 Neighboring gene VISTA enhancer hs807 Neighboring gene uncharacterized LOC102724143

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of cell division cycle associated 7-like (CDCA7L; JPO2) in human primary T cells PubMed
tat HIV-1 Tat-mediated stimulation of the viral LTR is increased in the presence of JPO2 PubMed
integrase gag-pol Both HIV-1 IN and JPO2 proteins are present as oligomers and co-localize in the nucleus of HeLa cells PubMed
gag-pol The IN catalytic core domain has a higher binding affinity (Kd) for PSIP1 (LEDGF/p75) than the physiological binding partner, CDCA7L (JOP2) PubMed
gag-pol The HIV-1 IN interaction site on the PSIP1 (LEDGF/p75) intergrase binding domain (IBD) overlaps with that of JPO2 PubMed
gag-pol HIV-1 IN and JPO2 bind mutually exclusively to LEDGF/p75. Two LEDGF/p75 mutants (I365A and D366N) abrogate interaction between LEDGF/p75 and IN but interact with JPO2 to the same extent as wild-type LEDGF/p75 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp762L0311

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cell division cycle-associated 7-like protein
Names
transcription factor RAM2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127370.3NP_001120842.1  cell division cycle-associated 7-like protein isoform 2

    See identical proteins and their annotated locations for NP_001120842.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 5' UTR which results in the use of a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA922229, AK022955, AK095965, AL576822, BC009352, BU753973, DA041070
    Consensus CDS
    CCDS47559.1
    UniProtKB/Swiss-Prot
    Q96GN5
    Related
    ENSP00000348523.5, ENST00000356195.9
    Conserved Domains (1) summary
    pfam10497
    Location:311409
    zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1
  2. NM_001127371.3NP_001120843.1  cell division cycle-associated 7-like protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame coding exon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AA922229, AK022955, AK300781, AL576822, BU753973, BX422040, DC331792
    Consensus CDS
    CCDS47558.1
    UniProtKB/Swiss-Prot
    Q96GN5
    Related
    ENSP00000363045.4, ENST00000373934.4
    Conserved Domains (1) summary
    pfam10497
    Location:299397
    zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1
  3. NM_018719.5NP_061189.2  cell division cycle-associated 7-like protein isoform 1

    See identical proteins and their annotated locations for NP_061189.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the predominant and longest protein (isoform 1).
    Source sequence(s)
    AA922229, AK022955, AK292490, AL576822, BC009352, BU753973
    Consensus CDS
    CCDS5374.1
    UniProtKB/Swiss-Prot
    Q96GN5
    UniProtKB/TrEMBL
    A0A024RA51, A8K8X5
    Related
    ENSP00000383986.3, ENST00000406877.8
    Conserved Domains (1) summary
    pfam10497
    Location:345443
    zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    21900899..21945899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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