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PRG2 proteoglycan 2, pro eosinophil major basic protein [ Homo sapiens (human) ]

Gene ID: 5553, updated on 21-Dec-2019

Summary

Official Symbol
PRG2provided by HGNC
Official Full Name
proteoglycan 2, pro eosinophil major basic proteinprovided by HGNC
Primary source
HGNC:HGNC:9362
See related
Ensembl:ENSG00000186652 MIM:605601
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MBP; BMPG; MBP1; proMBP
Summary
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Annotation information
Note: MBP is an alias on both PRG2 (Gene ID: 5553, "major basic protein") and MBL2 (Gene ID: 4153, "mannose-binding protein C"). MBP is also the official symbol on GeneID: 4155 (myelin basic protein). [01 Jun 2018]
Expression
Restricted expression toward placenta (RPKM 1164.9) See more
Orthologs

Genomic context

See PRG2 in Genome Data Viewer
Location:
11q12.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (57386780..57390650, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57154834..57171420, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X 3 Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2 Neighboring gene uncharacterized LOC105369312 Neighboring gene solute carrier family 43 member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-Tat peptide interferes with polyamine uptake via competition for proteoglycan binding sites rather than a putative downstream transporter in human carcinoma cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14537

Gene Ontology Provided by GOA

Process Evidence Code Pubs
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
transport vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
bone marrow proteoglycan
Names
eosinophil granule major basic protein
eosinophil major basic protein
natural killer cell activator
proteoglycan 2 preproprotein
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243245.3NP_001230174.1  bone marrow proteoglycan isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001230174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame donor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (2) missing a 11 aa protein segment compared to isoform 1.
    Source sequence(s)
    AP000781
    Consensus CDS
    CCDS58133.1
    UniProtKB/Swiss-Prot
    P13727
    Related
    ENSP00000433231.1, ENST00000533605.5
    Conserved Domains (1) summary
    cd03598
    Location:101211
    CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)
  2. NM_001302926.2NP_001289855.1  bone marrow proteoglycan isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001289855.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AP000781
    Consensus CDS
    CCDS7955.1
    UniProtKB/Swiss-Prot
    P13727
    Conserved Domains (1) summary
    cd03598
    Location:106222
    CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)
  3. NM_001302927.2NP_001289856.1  bone marrow proteoglycan isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001289856.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AP000781
    Consensus CDS
    CCDS7955.1
    UniProtKB/Swiss-Prot
    P13727
    Related
    ENSP00000433016.1, ENST00000525955.1
    Conserved Domains (1) summary
    cd03598
    Location:106222
    CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)
  4. NM_002728.6NP_002719.3  bone marrow proteoglycan isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_002719.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AP000781
    Consensus CDS
    CCDS7955.1
    UniProtKB/Swiss-Prot
    P13727
    Related
    ENSP00000312134.5, ENST00000311862.10
    Conserved Domains (1) summary
    cd03598
    Location:106222
    CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    57386780..57390650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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