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PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [ Homo sapiens (human) ]

Gene ID: 55529, updated on 17-Jun-2019

Summary

Official Symbol
PIP4P2provided by HGNC
Official Full Name
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2provided by HGNC
Primary source
HGNC:HGNC:25452
See related
Ensembl:ENSG00000155099 MIM:609864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM55A
Summary
TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 11.6), adrenal (RPKM 9.7) and 24 other tissues See more
Orthologs

Genomic context

See PIP4P2 in Genome Data Viewer
Location:
8q21.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (90993802..91040896, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (92006499..92053203, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene N-terminal EF-hand calcium binding protein 1 Neighboring gene uncharacterized LOC105375634 Neighboring gene chromosome 8 open reading frame 88 Neighboring gene OTUD6B antisense RNA 1 (head to head) Neighboring gene OTU domain containing 6B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp762O076

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Names
PtdIns-4,5-P(2) 4-phosphatase type II
ptdIns-4,5-P2 4-Ptase II
transmembrane protein 55A
type 2 PtdIns-4,5-P2 4-Ptase
type II PtdIns-4,5-P(2) 4-phosphatase
type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase
NP_061180.1
XP_011515454.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018710.3NP_061180.1  type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

    See identical proteins and their annotated locations for NP_061180.1

    Status: VALIDATED

    Source sequence(s)
    AC087439, AK313783, CR749733
    Consensus CDS
    CCDS6252.1
    UniProtKB/Swiss-Prot
    Q8N4L2
    Related
    ENSP00000285419.3, ENST00000285419.8
    Conserved Domains (1) summary
    pfam09788
    Location:6250
    Tmemb_55A; Transmembrane protein 55A

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    90993802..91040896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517152.3XP_011515454.1  type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1

    Conserved Domains (1) summary
    pfam09788
    Location:7181
    Tmemb_55A; Transmembrane protein 55A
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