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TRIM36 tripartite motif containing 36 [ Homo sapiens (human) ]

Gene ID: 55521, updated on 7-Jun-2020

Summary

Official Symbol
TRIM36provided by HGNC
Official Full Name
tripartite motif containing 36provided by HGNC
Primary source
HGNC:HGNC:16280
See related
Ensembl:ENSG00000152503 MIM:609317
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANPH; RNF98; HAPRIN; RBCC728
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 36.6), brain (RPKM 4.1) and 4 other tissues See more
Orthologs

Genomic context

See TRIM36 in Genome Data Viewer
Location:
5q22.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (115124772..115180546, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (114460459..114516243, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene potassium calcium-activated channel subfamily N member 2 Neighboring gene RN7SK pseudogene 89 Neighboring gene uncharacterized LOC101927078 Neighboring gene long intergenic non-protein coding RNA 1957 Neighboring gene protein geranylgeranyltransferase type I subunit beta Neighboring gene ribosomal protein S2 pseudogene 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of tripartite motif containing 36 (TRIM36) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acrosome reaction IEA
Inferred from Electronic Annotation
more info
 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM36
Names
RING finger protein 98
RING-type E3 ubiquitin transferase TRIM36
tripartite motif protein 36
tripartite motif-containing protein 36
zinc-binding protein Rbcc728
NP_001017397.1
NP_001017398.1
NP_001287681.1
NP_001287688.1
NP_061170.2
XP_016865110.1
XP_016865111.1
XP_016865112.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017397.2NP_001017397.1  E3 ubiquitin-protein ligase TRIM36 isoform 2

    See identical proteins and their annotated locations for NP_001017397.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several 3' exons, but has a much shorter and alternate 3' segment, as compared to variant 1. The resulting isoform (2) has a much shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    BC046096
    Consensus CDS
    CCDS34211.1
    UniProtKB/Swiss-Prot
    Q9NQ86
    Related
    ENSP00000368938.2, ENST00000379618.6
  2. NM_001017398.1NP_001017398.1  E3 ubiquitin-protein ligase TRIM36 isoform 3

    See identical proteins and their annotated locations for NP_001017398.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several 3' exons, but has a much shorter and alternate 3' segment, as compared to variant 1. The resulting isoform (3) has a much shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC008494, AI142389, BF592910
    Consensus CDS
    CCDS34212.1
    UniProtKB/Swiss-Prot
    Q9NQ86
    Related
    ENSP00000368937.2, ENST00000379617.2
  3. NM_001300752.2NP_001287681.1  E3 ubiquitin-protein ligase TRIM36 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal exon in the 5' region, which results in translation initiation at a downstream AUG start codon, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB196558, AC008494, AC094104, AJ272269
    Consensus CDS
    CCDS78047.1
    UniProtKB/Swiss-Prot
    Q9NQ86
    UniProtKB/TrEMBL
    E9PBG3, Q4R1Q4
    Related
    ENSP00000424259.1, ENST00000514154.1
    Conserved Domains (4) summary
    smart00060
    Location:276336
    FN3; Fibronectin type 3 domain
    cd00021
    Location:5694
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd12894
    Location:360563
    SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
    cl23765
    Location:101225
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  4. NM_001300759.2NP_001287688.1  E3 ubiquitin-protein ligase TRIM36 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' terminal exon, compared to variant 1. The resulting isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC094104, AJ272269, AK296389, AK316422
    Consensus CDS
    CCDS75287.1
    UniProtKB/Swiss-Prot
    Q9NQ86
    Related
    ENSP00000423934.1, ENST00000513154.5
    Conserved Domains (5) summary
    smart00060
    Location:419479
    FN3; Fibronectin type 3 domain
    cd00021
    Location:199237
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam13445
    Location:2149
    zf-RING_UBOX; RING-type zinc-finger
    cd12894
    Location:503706
    SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
    cl23765
    Location:244368
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  5. NM_018700.4NP_061170.2  E3 ubiquitin-protein ligase TRIM36 isoform 1

    See identical proteins and their annotated locations for NP_061170.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC008494, AC094104, AJ272269
    Consensus CDS
    CCDS4115.1
    UniProtKB/Swiss-Prot
    Q9NQ86
    Related
    ENSP00000282369.3, ENST00000282369.7
    Conserved Domains (5) summary
    smart00060
    Location:431491
    FN3; Fibronectin type 3 domain
    cd00021
    Location:211249
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam13445
    Location:3361
    zf-RING_UBOX; RING-type zinc-finger
    cd12894
    Location:515718
    SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
    cl23765
    Location:256380
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    115124772..115180546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009621.2XP_016865110.1  E3 ubiquitin-protein ligase TRIM36 isoform X1

  2. XM_017009622.2XP_016865111.1  E3 ubiquitin-protein ligase TRIM36 isoform X2

  3. XM_017009623.2XP_016865112.1  E3 ubiquitin-protein ligase TRIM36 isoform X3

RNA

  1. XR_002956164.1 RNA Sequence

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