Format

Send to:

Choose Destination

SRGN serglycin [ Homo sapiens (human) ]

Gene ID: 5552, updated on 1-Jun-2020

Summary

Official Symbol
SRGNprovided by HGNC
Official Full Name
serglycinprovided by HGNC
Primary source
HGNC:HGNC:9361
See related
Ensembl:ENSG00000122862 MIM:177040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPG; PRG; PRG1
Summary
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]
Expression
Biased expression in bone marrow (RPKM 1650.2), appendix (RPKM 289.1) and 5 other tissues See more
Orthologs

Genomic context

See SRGN in Genome Data Viewer
Location:
10q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (69057533..69104811)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (70847828..70864567)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ACTB pseudogene 14 Neighboring gene uncharacterized LOC105378342 Neighboring gene VPS26, retromer complex component A Neighboring gene ribosomal protein S12 pseudogene 17 Neighboring gene Suv3 like RNA helicase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9289, FLJ12930

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell secretory granule organization ISS
Inferred from Sequence or Structural Similarity
more info
 
biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
granzyme-mediated apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
maintenance of granzyme B location in T cell secretory granule ISS
Inferred from Sequence or Structural Similarity
more info
 
maintenance of protease location in mast cell secretory granule ISS
Inferred from Sequence or Structural Similarity
more info
 
mast cell secretory granule organization ISS
Inferred from Sequence or Structural Similarity
more info
 
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
negative regulation of bone mineralization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of bone mineralization IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cytokine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet degranulation TAS
Traceable Author Statement
more info
 
protein processing ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of postsynapse organization IEA
Inferred from Electronic Annotation
more info
 
secretory granule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
mast cell granule ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
postsynaptic specialization, intracellular component IEA
Inferred from Electronic Annotation
more info
 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serglycin
Names
hematopoetic proteoglycan core peptide
hematopoetic proteoglycan core protein
hematopoietic proteoglycan core protein
p.PG
platelet proteoglycan core protein
proteoglycan 1, secretory granule
proteoglycan protein core for mast cell secretory granule
secretory granule proteoglycan core peptide
secretory granule proteoglycan core protein
serglycin proteoglycan

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321053.2NP_001307982.1  serglycin isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 3 encode isoform 1.
    Source sequence(s)
    AL442635, BC015516, BP363056
    Consensus CDS
    CCDS7285.1
    UniProtKB/Swiss-Prot
    P10124
    Conserved Domains (1) summary
    pfam04360
    Location:3150
    Serglycin; Serglycin
  2. NM_001321054.1NP_001307983.1  serglycin isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon in the coding region resulting in a frameshift compared to variant 1. The encoded isoform (2) is shorter, has a distinct N-terminus, and lacks a predicted signal peptide compared to isoform 1.
    Source sequence(s)
    AI347627, AL442635, BC015516, BP335278, BQ051861, CD677686
    UniProtKB/Swiss-Prot
    P10124
    Conserved Domains (1) summary
    pfam04360
    Location:2294
    Serglycin; Serglycin
  3. NM_002727.4NP_002718.2  serglycin isoform 1 precursor

    See identical proteins and their annotated locations for NP_002718.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an exon in the 5' UTR compared to variant 2. Both variants 1 and 3 encode isoform 1.
    Source sequence(s)
    BC015516, BG057351, BG548665, CA308463, CB110512
    Consensus CDS
    CCDS7285.1
    UniProtKB/Swiss-Prot
    P10124
    Related
    ENSP00000242465.3, ENST00000242465.4
    Conserved Domains (1) summary
    pfam04360
    Location:3150
    Serglycin; Serglycin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    69057533..69104811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448066.1XP_024303834.1  serglycin isoform X1

    Conserved Domains (1) summary
    pfam04360
    Location:3150
    Serglycin; Serglycin
  2. XM_024448064.1XP_024303832.1  serglycin isoform X1

    Conserved Domains (1) summary
    pfam04360
    Location:3150
    Serglycin; Serglycin
  3. XM_024448065.1XP_024303833.1  serglycin isoform X1

    Conserved Domains (1) summary
    pfam04360
    Location:3150
    Serglycin; Serglycin
  4. XM_017016392.2XP_016871881.1  serglycin isoform X1

    UniProtKB/Swiss-Prot
    P10124
    Conserved Domains (1) summary
    pfam04360
    Location:3150
    Serglycin; Serglycin
Support Center