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SAGE1 sarcoma antigen 1 [ Homo sapiens (human) ]

Gene ID: 55511, updated on 12-Oct-2019

Summary

Official Symbol
SAGE1provided by HGNC
Official Full Name
sarcoma antigen 1provided by HGNC
Primary source
HGNC:HGNC:30369
See related
Ensembl:ENSG00000181433 MIM:300359
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT14; SAGE
Summary
This gene belongs to a class of genes that are activated in tumors. These genes are expressed in tumors of different histologic types but not in normal tissues, except for spermatogenic cells and, for some, placenta. The proteins encoded by these genes appear to be strictly tumor specific, and hence may be excellent sources of antigens for cancer immunotherapy. This gene is expressed in sarcomas. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 2.8) See more
Orthologs

Genomic context

See SAGE1 in Genome Data Viewer
Location:
Xq26.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (135893607..135913062)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134975785..134995221)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cancer/testis antigen family 45 member A9 Neighboring gene cancer/testis antigen family 45 member A10 Neighboring gene Sharpr-MPRA regulatory region 13624 Neighboring gene cancer/testis antigen family 45 member A11, pseudogene Neighboring gene membrane magnesium transporter 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
sarcoma antigen 1
Names
cancer/testis antigen 14
putative tumor antigen

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012571.1 RefSeqGene

    Range
    5083..24437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018666.3NP_061136.2  sarcoma antigen 1

    See identical proteins and their annotated locations for NP_061136.2

    Status: REVIEWED

    Source sequence(s)
    AJ278111, AL953870, BF056519, CD358947
    Consensus CDS
    CCDS14652.1
    UniProtKB/Swiss-Prot
    Q9NXZ1
    Related
    ENSP00000359743.3, ENST00000370709.3
    Conserved Domains (1) summary
    pfam15300
    Location:823884
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    135893607..135913062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029621.1XP_016885110.1  sarcoma antigen 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NXZ1
    Conserved Domains (1) summary
    pfam15300
    Location:823884
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
  2. XM_017029625.1XP_016885114.1  sarcoma antigen 1 isoform X4

  3. XM_017029623.1XP_016885112.1  sarcoma antigen 1 isoform X2

  4. XM_017029624.1XP_016885113.1  sarcoma antigen 1 isoform X3

  5. XM_017029622.1XP_016885111.1  sarcoma antigen 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NXZ1
    Conserved Domains (1) summary
    pfam15300
    Location:823884
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
  6. XM_017029627.1XP_016885116.1  sarcoma antigen 1 isoform X6

  7. XM_017029626.1XP_016885115.1  sarcoma antigen 1 isoform X5

RNA

  1. XR_001755708.1 RNA Sequence

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