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BATF3 basic leucine zipper ATF-like transcription factor 3 [ Homo sapiens (human) ]

Gene ID: 55509, updated on 1-Jun-2020

Summary

Official Symbol
BATF3provided by HGNC
Official Full Name
basic leucine zipper ATF-like transcription factor 3provided by HGNC
Primary source
HGNC:HGNC:28915
See related
Ensembl:ENSG00000123685 MIM:612470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JDP1; SNFT; JUNDM1
Summary
This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009]
Expression
Broad expression in spleen (RPKM 2.9), appendix (RPKM 1.9) and 20 other tissues See more
Orthologs

Genomic context

See BATF3 in Genome Data Viewer
Location:
1q32.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (212686417..212699943, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (212859759..212873327, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2773 Neighboring gene family with sequence similarity 71 member A Neighboring gene riboflavin kinase pseudogene Neighboring gene NSL1 component of MIS12 kinetochore complex Neighboring gene TatD DNase domain containing 3 Neighboring gene RPS5 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36352, FLJ37535

Gene Ontology Provided by GOA

Process Evidence Code Pubs
dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
myeloid dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
basic leucine zipper transcriptional factor ATF-like 3
Names
21 kDa small nuclear factor isolated from T-cells
21-kD small nuclear factor isolated from T cells
B-ATF-3
Jun dimerization protein 1
Jun dimerization protein p21SNFT
basic leucine zipper transcription factor, ATF-like 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018664.3NP_061134.1  basic leucine zipper transcriptional factor ATF-like 3

    See identical proteins and their annotated locations for NP_061134.1

    Status: REVIEWED

    Source sequence(s)
    AF255346, BC117491, BG184570
    Consensus CDS
    CCDS1508.1
    UniProtKB/Swiss-Prot
    Q9NR55
    Related
    ENSP00000243440.1, ENST00000243440.2
    Conserved Domains (2) summary
    cd14686
    Location:3889
    bZIP; coiled coil [structural motif]
    cl21462
    Location:3592
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    212686417..212699943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001683.1XP_016857172.1  basic leucine zipper transcriptional factor ATF-like 3 isoform X1

RNA

  1. XR_921869.2 RNA Sequence

  2. XR_001737289.1 RNA Sequence

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