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GPRC5D G protein-coupled receptor class C group 5 member D [ Homo sapiens (human) ]

Gene ID: 55507, updated on 12-Oct-2019

Summary

Official Symbol
GPRC5Dprovided by HGNC
Official Full Name
G protein-coupled receptor class C group 5 member Dprovided by HGNC
Primary source
HGNC:HGNC:13310
See related
Ensembl:ENSG00000111291 MIM:607437
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See GPRC5D in Genome Data Viewer
Location:
12p13.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (12940518..12955908, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (13093407..13106828, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RPL13AP20-GPRC5A intergenic CAGE-defined mid-level expression enhancer Neighboring gene G protein-coupled receptor class C group 5 member A Neighboring gene microRNA 614 Neighboring gene GPRC5D and HEBP1 antisense RNA 1 Neighboring gene heme binding protein 1 Neighboring gene 5-hydroxytryptamine receptor 7 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129713, MGC129714

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
G-protein coupled receptor family C group 5 member D
Names
orphan G-protein coupled receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018654.1NP_061124.1  G-protein coupled receptor family C group 5 member D

    See identical proteins and their annotated locations for NP_061124.1

    Status: REVIEWED

    Source sequence(s)
    AF209923
    Consensus CDS
    CCDS8658.1
    UniProtKB/Swiss-Prot
    Q9NZD1
    Related
    ENSP00000228887.1, ENST00000228887.5
    Conserved Domains (2) summary
    cd14964
    Location:2246
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:21267
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    12940518..12955908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253421.3XP_005253478.1  G-protein coupled receptor family C group 5 member D isoform X1

    See identical proteins and their annotated locations for XP_005253478.1

    UniProtKB/Swiss-Prot
    Q9NZD1
    Conserved Domains (2) summary
    cd14964
    Location:2246
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:21267
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_017019582.2XP_016875071.1  G-protein coupled receptor family C group 5 member D isoform X1

    UniProtKB/Swiss-Prot
    Q9NZD1
    Conserved Domains (2) summary
    cd14964
    Location:2246
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:21267
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. XM_017019583.2XP_016875072.1  G-protein coupled receptor family C group 5 member D isoform X2

    UniProtKB/Swiss-Prot
    Q9NZD1
    Related
    ENSP00000379624.3, ENST00000396333.3
    Conserved Domains (1) summary
    pfam00003
    Location:75264
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
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