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MACROH2A2 macroH2A.2 histone [ Homo sapiens (human) ]

Gene ID: 55506, updated on 5-Sep-2021

Summary

Official Symbol
MACROH2A2provided by HGNC
Official Full Name
macroH2A.2 histoneprovided by HGNC
Primary source
HGNC:HGNC:14453
See related
Ensembl:ENSG00000099284 MIM:616141
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2AFY2
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. [provided by RefSeq, Oct 2015]
Expression
Ubiquitous expression in endometrium (RPKM 13.3), prostate (RPKM 7.9) and 23 other tissues See more
Orthologs
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Genomic context

See MACROH2A2 in Genome Data Viewer
Location:
10q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (70052846..70112282)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (71812602..71872038)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene collagen type XIII alpha 1 chain Neighboring gene uncharacterized LOC107984242 Neighboring gene long intergenic non-protein coding RNA 2636 Neighboring gene HNF4 motif-containing MPRA enhancer 70 Neighboring gene apoptosis inducing factor mitochondria associated 2 Neighboring gene trypsin like peroxisomal matrix peptidase 1 Neighboring gene secretion associated Ras related GTPase 1A Neighboring gene calmodulin 2 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Barr body IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region HDA PubMed 
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
core histone macro-H2A.2
Names
H2A histone family member Y2
core histone macroH2A2.2
histone macroH2A2
mH2A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018649.3NP_061119.1  core histone macro-H2A.2

    See identical proteins and their annotated locations for NP_061119.1

    Status: REVIEWED

    Source sequence(s)
    AC024601, AL731540
    Consensus CDS
    CCDS7296.1
    UniProtKB/Swiss-Prot
    Q9P0M6
    UniProtKB/TrEMBL
    A0A024QZP6
    Related
    ENSP00000362352.3, ENST00000373255.9
    Conserved Domains (2) summary
    cd00074
    Location:5117
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
    cd02904
    Location:178368
    Macro_H2A-like; macrodomain, macroH2A-like family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    70052846..70112282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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