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NOP10 NOP10 ribonucleoprotein [ Homo sapiens (human) ]

Gene ID: 55505, updated on 13-Mar-2020

Summary

Official Symbol
NOP10provided by HGNC
Official Full Name
NOP10 ribonucleoproteinprovided by HGNC
Primary source
HGNC:HGNC:14378
See related
Ensembl:ENSG00000182117 MIM:606471
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DKCB1; NOLA3; NOP10P
Summary
This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 45.9), spleen (RPKM 43.6) and 25 other tissues See more
Orthologs

Genomic context

See NOP10 in Genome Data Viewer
Location:
15q14
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (34341719..34343136, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34633917..34635362, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene katanin regulatory subunit B1 like 1 Neighboring gene solute carrier family 12 member 6 Neighboring gene ER membrane protein complex subunit 4 Neighboring gene NUT midline carcinoma family member 1 Neighboring gene lysophosphatidylcholine acyltransferase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of NOP10 ribonucleoprotein (NOP10) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC70651

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
box H/ACA snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
box H/ACA snoRNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
telomerase RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomerase RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
telomerase RNA binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
positive regulation of telomerase RNA localization to Cajal body HMP PubMed 
pseudouridine synthesis NAS
Non-traceable Author Statement
more info
PubMed 
rRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA pseudouridine synthesis TAS
Traceable Author Statement
more info
 
snRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
snoRNA guided rRNA pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
 
telomere maintenance via telomerase IDA
Inferred from Direct Assay
more info
PubMed 
telomere maintenance via telomerase TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
box H/ACA scaRNP complex TAS
Traceable Author Statement
more info
PubMed 
box H/ACA snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
box H/ACA snoRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
box H/ACA snoRNP complex TAS
Traceable Author Statement
more info
PubMed 
box H/ACA telomerase RNP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
box H/ACA telomerase RNP complex IDA
Inferred from Direct Assay
more info
PubMed 
box H/ACA telomerase RNP complex TAS
Traceable Author Statement
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
small nucleolar ribonucleoprotein complex TAS
Traceable Author Statement
more info
PubMed 
telomerase holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
telomerase holoenzyme complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
H/ACA ribonucleoprotein complex subunit 3
Names
NOP10 ribonucleoprotein homolog
homolog of yeast Nop10p
nucleolar protein 10
nucleolar protein family A member 3
nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs)
snoRNP protein NOP10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011562.1 RefSeqGene

    Range
    5001..6446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_345

mRNA and Protein(s)

  1. NM_018648.4NP_061118.1  H/ACA ribonucleoprotein complex subunit 3

    See identical proteins and their annotated locations for NP_061118.1

    Status: REVIEWED

    Source sequence(s)
    BM554889, BQ218536
    Consensus CDS
    CCDS10037.1
    UniProtKB/Swiss-Prot
    Q9NPE3
    Related
    ENSP00000332198.4, ENST00000328848.5
    Conserved Domains (1) summary
    pfam04135
    Location:652
    Nop10p; Nucleolar RNA-binding protein, Nop10p family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    34341719..34343136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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