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TNFRSF19 TNF receptor superfamily member 19 [ Homo sapiens (human) ]

Gene ID: 55504, updated on 22-Aug-2020

Summary

Official Symbol
TNFRSF19provided by HGNC
Official Full Name
TNF receptor superfamily member 19provided by HGNC
Primary source
HGNC:HGNC:11915
See related
Ensembl:ENSG00000127863 MIM:606122
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAJ; TROY; TRADE; TAJ-alpha
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 37.6), prostate (RPKM 12.9) and 8 other tissues See more
Orthologs

Genomic context

See TNFRSF19 in Genome Data Viewer
Location:
13q12.12
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (23570248..23676093)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (24144509..24250244)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene sacsin molecular chaperone Neighboring gene SACS antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 327 Neighboring gene uncharacterized LOC105370114 Neighboring gene uncharacterized LOC105370113 Neighboring gene mitochondrial intermediate peptidase Neighboring gene MT-CO3 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
GeneReviews: Not available
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
GeneReviews: Not available
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available
Novel associations for hypothyroidism include known autoimmune risk loci.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tumor necrosis factor-activated receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
JNK cascade NAS
Non-traceable Author Statement
more info
PubMed 
apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
hair follicle development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 19
Names
toxicity and JNK inducer

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204458.3NP_001191387.1  tumor necrosis factor receptor superfamily member 19 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001191387.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and the 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform (1). Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AY358888, BC047321, BF968836, BF971156, BM801444, DB223760
    Consensus CDS
    CCDS9301.1
    UniProtKB/Swiss-Prot
    Q9NS68
    Related
    ENSP00000371698.3, ENST00000382263.3
    Conserved Domains (1) summary
    cd13418
    Location:33149
    TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY
  2. NM_001204459.2NP_001191388.1  tumor necrosis factor receptor superfamily member 19 isoform 3

    See identical proteins and their annotated locations for NP_001191388.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in both UTR's and the 3' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK304290, AY358888, BC047321, BF968836, BF971156, BM801444, DA192370
    Consensus CDS
    CCDS55893.1
    UniProtKB/Swiss-Prot
    Q9NS68
    Related
    ENSP00000385408.2, ENST00000403372.6
    Conserved Domains (1) summary
    cl22855
    Location:117
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  3. NM_001354985.2NP_001341914.1  tumor necrosis factor receptor superfamily member 19 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AL161422, AL354815
    Conserved Domains (1) summary
    cd13418
    Location:33149
    TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY
  4. NM_018647.5NP_061117.2  tumor necrosis factor receptor superfamily member 19 isoform 1 precursor

    See identical proteins and their annotated locations for NP_061117.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as TRADEbeta) encodes the longest isoform (1).
    Source sequence(s)
    AF167555, AL161422, BC047321, DB223760
    Consensus CDS
    CCDS9302.1
    UniProtKB/Swiss-Prot
    Q9NS68
    UniProtKB/TrEMBL
    A0A024RDM5
    Related
    ENSP00000371693.4, ENST00000382258.8
    Conserved Domains (1) summary
    cd13418
    Location:33149
    TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY
  5. NM_148957.4NP_683760.1  tumor necrosis factor receptor superfamily member 19 isoform 2 precursor

    See identical proteins and their annotated locations for NP_683760.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as TRADEalpha) differs in both UTR's and the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform (1). Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AY358888, BC047321, BF968836, BF971156, BM801444, DA192370
    Consensus CDS
    CCDS9301.1
    UniProtKB/Swiss-Prot
    Q9NS68
    Related
    ENSP00000248484.4, ENST00000248484.8
    Conserved Domains (1) summary
    cd13418
    Location:33149
    TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    23570248..23676093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020651.1XP_016876140.1  tumor necrosis factor receptor superfamily member 19 isoform X1

    UniProtKB/Swiss-Prot
    Q9NS68
    UniProtKB/TrEMBL
    A0A024RDM5
    Conserved Domains (1) summary
    cd13418
    Location:33149
    TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY
  2. XM_005266446.2XP_005266503.1  tumor necrosis factor receptor superfamily member 19 isoform X2

    See identical proteins and their annotated locations for XP_005266503.1

    Conserved Domains (1) summary
    cd13418
    Location:33149
    TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY
  3. XM_005266445.3XP_005266502.1  tumor necrosis factor receptor superfamily member 19 isoform X1

    See identical proteins and their annotated locations for XP_005266502.1

    UniProtKB/Swiss-Prot
    Q9NS68
    UniProtKB/TrEMBL
    A0A024RDM5
    Conserved Domains (1) summary
    cd13418
    Location:33149
    TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY
  4. XM_011535146.1XP_011533448.1  tumor necrosis factor receptor superfamily member 19 isoform X1

    See identical proteins and their annotated locations for XP_011533448.1

    UniProtKB/Swiss-Prot
    Q9NS68
    UniProtKB/TrEMBL
    A0A024RDM5
    Conserved Domains (1) summary
    cd13418
    Location:33149
    TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY
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