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PREP prolyl endopeptidase [ Homo sapiens (human) ]

Gene ID: 5550, updated on 8-Dec-2018

Summary

Official Symbol
PREPprovided by HGNC
Official Full Name
prolyl endopeptidaseprovided by HGNC
Primary source
HGNC:HGNC:9358
See related
Ensembl:ENSG00000085377 MIM:600400
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PE; PEP
Summary
The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides. [provided by RefSeq, Jul 2008]
Annotation information
Note: The official gene symbol PREP (prolyl endopeptidase) on GeneID: 5550 can be confused with the alias for presequence protease (PREP) on GeneID: 10531 whose official symbol is PITRM1 (pitrilysin metallopeptidase 1). [20 Jun 2018]
Expression
Ubiquitous expression in colon (RPKM 8.2), testis (RPKM 5.6) and 25 other tissues See more
Orthologs

Genomic context

See PREP in Genome Data Viewer
Location:
6q21
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (105277567..105403124, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (105725442..105850999, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene blood vessel epicardial substance Neighboring gene BVES antisense RNA 1 Neighboring gene popeye domain containing 3 Neighboring gene uncharacterized LOC105377920 Neighboring gene ribosomal protein L7a pseudogene 35 Neighboring gene ribosomal protein L35 pseudogene 3 Neighboring gene uncharacterized LOC105377921 Neighboring gene uncharacterized LOC105377922

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Renin-angiotensin system, organism-specific biosystem (from KEGG)
    Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Renin-angiotensin system, conserved biosystem (from KEGG)
    Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC16060

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type exopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type peptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
prolyl endopeptidase
Names
dJ355L5.1 (prolyl endopeptidase)
post-proline cleaving enzyme
prolyl oligopeptidase
NP_002717.3
XP_005267101.1
XP_011534227.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011472.1 RefSeqGene

    Range
    4971..130528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002726.4NP_002717.3  prolyl endopeptidase

    See identical proteins and their annotated locations for NP_002717.3

    Status: REVIEWED

    Source sequence(s)
    AK314195, AL133406, BC030636, DA790125
    Consensus CDS
    CCDS5053.1
    UniProtKB/Swiss-Prot
    P48147
    UniProtKB/TrEMBL
    B2RAH7
    Related
    ENSP00000358106.3, ENST00000369110.7
    Conserved Domains (2) summary
    COG1505
    Location:26704
    PreP; Prolyl oligopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism]
    pfam00326
    Location:482707
    Peptidase_S9; Prolyl oligopeptidase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    105277567..105403124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535925.3XP_011534227.1  prolyl endopeptidase isoform X1

    Conserved Domains (1) summary
    pfam02897
    Location:7423
    Peptidase_S9_N; Prolyl oligopeptidase, N-terminal beta-propeller domain
  2. XM_005267044.3XP_005267101.1  prolyl endopeptidase isoform X2

    Conserved Domains (1) summary
    pfam02897
    Location:7423
    Peptidase_S9_N; Prolyl oligopeptidase, N-terminal beta-propeller domain
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