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PRCP prolylcarboxypeptidase [ Homo sapiens (human) ]

Gene ID: 5547, updated on 11-Sep-2019

Summary

Official Symbol
PRCPprovided by HGNC
Official Full Name
prolylcarboxypeptidaseprovided by HGNC
Primary source
HGNC:HGNC:9344
See related
Ensembl:ENSG00000137509 MIM:176785
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCP; HUMPCP
Summary
This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in placenta (RPKM 42.6), urinary bladder (RPKM 37.6) and 25 other tissues See more
Orthologs

Genomic context

See PRCP in Genome Data Viewer
Location:
11q14.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (82822936..82901740, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (82535409..82612733, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 181 member B Neighboring gene long intergenic non-protein coding RNA 2734 Neighboring gene RBMX pseudogene 3 Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 6 Neighboring gene MIR3 retrotransposon enhancer-blocking element Neighboring gene DNA damage induced apoptosis suppressor Neighboring gene ribosomal protein L7a pseudogene 54 Neighboring gene RAB30, member RAS oncogene family Neighboring gene small nucleolar RNA, H/ACA box 70E

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem (from REACTOME)
    Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystemThe formation of a fibrin clot at the site of an injury to the wall of a normal blood vessel is an essential part of the process to stop blood loss after vascular injury. The reactions that lead to ...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Intrinsic Pathway of Fibrin Clot Formation, organism-specific biosystem (from REACTOME)
    Intrinsic Pathway of Fibrin Clot Formation, organism-specific biosystemThe intrinsic pathway of blood clotting connects interactions among kininogen (high molecular weight kininogen, HK), prekallikrein (PK), and factor XII to the activation of clotting factor X by a ser...
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Protein digestion and absorption, organism-specific biosystem (from KEGG)
    Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Protein digestion and absorption, conserved biosystem (from KEGG)
    Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Renin-angiotensin system, organism-specific biosystem (from KEGG)
    Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Renin-angiotensin system, conserved biosystem (from KEGG)
    Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2202

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type carboxypeptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
angiogenesis involved in wound healing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
blood coagulation, intrinsic pathway TAS
Traceable Author Statement
more info
 
energy homeostasis IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
plasma kallikrein-kinin cascade IEA
Inferred from Electronic Annotation
more info
 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of blood vessel endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of thyroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
azurophil granule membrane TAS
Traceable Author Statement
more info
 
basal part of cell IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
lysosomal Pro-X carboxypeptidase
Names
angiotensinase C
lysosomal carboxypeptidase C
proline carboxypeptidase
NP_001306143.1
NP_005031.1
NP_955450.2
XP_005274150.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319214.1NP_001306143.1  lysosomal Pro-X carboxypeptidase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus and lacks a predicted signal peptide compared to isoform 1.
    Source sequence(s)
    AA477618, AK302386, AP001646, AW627417, BC001500, BE154586, CB154314, DB028823
    UniProtKB/Swiss-Prot
    P42785
    UniProtKB/TrEMBL
    B7Z7Q6
    Conserved Domains (1) summary
    cl21494
    Location:1372
    Abhydrolase; alpha/beta hydrolases
  2. NM_005040.4NP_005031.1  lysosomal Pro-X carboxypeptidase isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_005031.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AA477618, AP001646, AW627417, BC001500, BE154586, BI827978, CB154314
    Consensus CDS
    CCDS8262.1
    UniProtKB/Swiss-Prot
    P42785
    UniProtKB/TrEMBL
    A0A024R5L0
    Related
    ENSP00000317362.3, ENST00000313010.8
    Conserved Domains (2) summary
    COG0596
    Location:104214
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:55477
    Abhydrolase; alpha/beta hydrolases
  3. NM_199418.3NP_955450.2  lysosomal Pro-X carboxypeptidase isoform 2 precursor

    See identical proteins and their annotated locations for NP_955450.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is longer than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AA477618, AK091786, AP001646, AW627417, BC001500, BE154586, BI827978, CB154314, DB444448
    Consensus CDS
    CCDS41695.1
    UniProtKB/Swiss-Prot
    P42785
    Related
    ENSP00000377055.2, ENST00000393399.6
    Conserved Domains (2) summary
    COG0596
    Location:125235
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:78498
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    82822936..82901740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274093.1XP_005274150.1  lysosomal Pro-X carboxypeptidase isoform X1

    See identical proteins and their annotated locations for XP_005274150.1

    UniProtKB/TrEMBL
    B7Z7Q6
    Conserved Domains (1) summary
    cl21494
    Location:1372
    Abhydrolase; alpha/beta hydrolases
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