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DNAJA4 DnaJ heat shock protein family (Hsp40) member A4 [ Homo sapiens (human) ]

Gene ID: 55466, updated on 5-Sep-2021

Summary

Official Symbol
DNAJA4provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member A4provided by HGNC
Primary source
HGNC:HGNC:14885
See related
Ensembl:ENSG00000140403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST104; MSTP104; PRO1472
Expression
Broad expression in heart (RPKM 43.9), testis (RPKM 33.4) and 23 other tissues See more
Orthologs
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Genomic context

See DNAJA4 in Genome Data Viewer
Location:
15q25.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (78264145..78282191)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (78556487..78574533)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha Neighboring gene acyl-CoA synthetase bubblegum family member 1 Neighboring gene DNAJA4 divergent transcript Neighboring gene uncharacterized LOC105370910 Neighboring gene WD repeat domain 61 Neighboring gene cellular retinoic acid binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dnaJ homolog subfamily A member 4
Names
DnaJ (Hsp40) homolog, subfamily A, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130182.2NP_001123654.1  dnaJ homolog subfamily A member 4 isoform 2

    See identical proteins and their annotated locations for NP_001123654.1

    Status: VALIDATED

    Source sequence(s)
    AC090607
    Consensus CDS
    CCDS45316.1
    UniProtKB/Swiss-Prot
    Q8WW22
    UniProtKB/TrEMBL
    Q69YX3
    Related
    ENSP00000378321.3, ENST00000394852.8
    Conserved Domains (1) summary
    PTZ00037
    Location:2394
    PTZ00037; DnaJ_C chaperone protein; Provisional
  2. NM_001130183.2NP_001123655.1  dnaJ homolog subfamily A member 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC090607, AK096616, AL133096, BC031044, DA561365
    Consensus CDS
    CCDS45317.1
    UniProtKB/Swiss-Prot
    Q8WW22
    UniProtKB/TrEMBL
    Q69YX3
    Related
    ENSP00000413499.2, ENST00000446172.2
    Conserved Domains (4) summary
    PRK14277
    Location:7354
    PRK14277; chaperone protein DnaJ; Provisional
    cd10719
    Location:108174
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:79305
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    cl02542
    Location:938
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
  3. NM_001387384.1NP_001374313.1  dnaJ homolog subfamily A member 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC090607
    Conserved Domains (1) summary
    PTZ00037
    Location:2412
    PTZ00037; DnaJ_C chaperone protein; Provisional
  4. NM_001387385.1NP_001374314.1  dnaJ homolog subfamily A member 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC090607
    Conserved Domains (1) summary
    PTZ00037
    Location:2394
    PTZ00037; DnaJ_C chaperone protein; Provisional
  5. NM_001387386.1NP_001374315.1  dnaJ homolog subfamily A member 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC090607
    Conserved Domains (1) summary
    PTZ00037
    Location:2317
    PTZ00037; DnaJ_C chaperone protein; Provisional
  6. NM_001387387.1NP_001374316.1  dnaJ homolog subfamily A member 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC090607
    Conserved Domains (2) summary
    COG0484
    Location:2110
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cl21722
    Location:106144
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
  7. NM_001387388.1NP_001374317.1  dnaJ homolog subfamily A member 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC090607
    Related
    ENSP00000339581.3, ENST00000343789.7
    Conserved Domains (1) summary
    PTZ00037
    Location:2394
    PTZ00037; DnaJ_C chaperone protein; Provisional
  8. NM_018602.4NP_061072.3  dnaJ homolog subfamily A member 4 isoform 1

    See identical proteins and their annotated locations for NP_061072.3

    Status: VALIDATED

    Source sequence(s)
    AC090607, AK096616, AL133096, BC021720, DB047940
    Consensus CDS
    CCDS10299.2
    UniProtKB/Swiss-Prot
    Q8WW22
    UniProtKB/TrEMBL
    Q69YX3
    Related
    ENSP00000378324.3, ENST00000394855.7
    Conserved Domains (4) summary
    cd10719
    Location:164230
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:135361
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    PTZ00037
    Location:15423
    PTZ00037; DnaJ_C chaperone protein; Provisional
    pfam00226
    Location:3694
    DnaJ; DnaJ domain

RNA

  1. NR_170653.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090607
  2. NR_170654.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090607
  3. NR_170655.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090607
  4. NR_170656.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090607
  5. NR_170657.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090607
  6. NR_170658.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090607
  7. NR_170666.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090607

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    78264145..78282191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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