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PRB3 proline rich protein BstNI subfamily 3 [ Homo sapiens (human) ]

Gene ID: 5544, updated on 23-Nov-2021

Summary

Official Symbol
PRB3provided by HGNC
Official Full Name
proline rich protein BstNI subfamily 3provided by HGNC
Primary source
HGNC:HGNC:9339
See related
Ensembl:ENSG00000197870 MIM:168840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G1; PRG
Summary
This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Long" allele. The protein isoforms encoded by this gene are recognized as the "first line of oral defense" against the detrimental effects of polyphenols in the diet and pathogen infections. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Nov 2015]
Expression
Restricted expression toward salivary gland (RPKM 9550.6) See more
Orthologs
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Genomic context

See PRB3 in Genome Data Viewer
Location:
12p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (11265914..11269707, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (11418847..11422641, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene taste 2 receptor member 42 Neighboring gene taste 2 receptor member 7 pseudogene Neighboring gene uncharacterized LOC107987183 Neighboring gene proline rich protein BstNI subfamily 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC116862, MGC116863, MGC116864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in defense response to Gram-negative bacterium NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
basic salivary proline-rich protein 3
Names
BstNI type basic salivary proline-rich protein 3
G1 parotid salivary glycoprotein
parotid salivary glycoprotein G1
proline-rich protein G1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013305.2 RefSeqGene

    Range
    5001..8794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001394862.1NP_001381791.1  basic salivary proline-rich protein 3 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC010176, AC244131
    Conserved Domains (1) summary
    PRK07764
    Location:50264
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
  2. NM_006249.5NP_006240.4  basic salivary proline-rich protein 3 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC010176, AC244131
    UniProtKB/TrEMBL
    A0A0G2JNB4
    Related
    ENSP00000371264.3, ENST00000381842.7
    Conserved Domains (2) summary
    pfam10240
    Location:44108
    DUF2464; Protein of unknown function (DUF2464)
    pfam15240
    Location:7188
    Pro-rich; Proline-rich

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    11265914..11269707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187658.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    460877..464670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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