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AP1AR adaptor related protein complex 1 associated regulatory protein [ Homo sapiens (human) ]

Gene ID: 55435, updated on 1-Jun-2020

Summary

Official Symbol
AP1ARprovided by HGNC
Official Full Name
adaptor related protein complex 1 associated regulatory proteinprovided by HGNC
Primary source
HGNC:HGNC:28808
See related
Ensembl:ENSG00000138660 MIM:610851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
2C18; GBAR; C4orf16; PRO0971; gamma-BAR
Expression
Ubiquitous expression in small intestine (RPKM 6.6), kidney (RPKM 6.1) and 25 other tissues See more
Orthologs

Genomic context

See AP1AR in Genome Data Viewer
Location:
4q25
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (112231787..112273110)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (113152893..113191211)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377370 Neighboring gene family with sequence similarity 241 member A Neighboring gene ribosomal protein L36a pseudogene 19 Neighboring gene Sharpr-MPRA regulatory region 9995 Neighboring gene TRAF interacting protein with forkhead associated domain Neighboring gene alpha kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AP-1 adaptor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AP-1 adaptor complex binding IDA
Inferred from Direct Assay
more info
PubMed 
kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinesin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell motility IEA
Inferred from Electronic Annotation
more info
 
negative regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
 
vesicle targeting, trans-Golgi to endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle targeting, trans-Golgi to endosome IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome IEA
Inferred from Electronic Annotation
more info
 
transport vesicle IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
AP-1 complex-associated regulatory protein
Names
adapter-related protein complex 1-associated regulatory protein
gadkin
gamma-1-adaptin brefeldin A resistance protein
gamma-A1-adaptin and kinesin interactor
gamma1-adaptin brefeldin A resistance protein, gamma-BAR

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128426.3NP_001121898.1  AP-1 complex-associated regulatory protein isoform 2

    See identical proteins and their annotated locations for NP_001121898.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the mid-coding region compared to variant 1. The resulting shorter isoform (2) has the same N- and C- termini but lacks an internal protein segment compared to isoform 1.
    Source sequence(s)
    AC109347, AF116612, AI246762, AI798931, BC009485, BU740563, BX498932, CN291547, DA463845
    Consensus CDS
    CCDS47125.1
    UniProtKB/Swiss-Prot
    Q63HQ0
    UniProtKB/TrEMBL
    A0A024RDI1
    Related
    ENSP00000309023.6, ENST00000309703.10
    Conserved Domains (1) summary
    pfam15745
    Location:26269
    AP1AR; AP-1 complex-associated regulatory protein
  2. NM_018569.6NP_061039.3  AP-1 complex-associated regulatory protein isoform 1

    See identical proteins and their annotated locations for NP_061039.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC109347, AF116612, AI246762, AI798931, BU740563, BX498932, BX647702, CN291547
    Consensus CDS
    CCDS3696.1
    UniProtKB/Swiss-Prot
    Q63HQ0
    UniProtKB/TrEMBL
    A0A024RDK6
    Related
    ENSP00000274000.5, ENST00000274000.10
    Conserved Domains (1) summary
    pfam15745
    Location:26302
    AP1AR; AP-1 complex-associated regulatory protein

RNA

  1. NR_136622.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate acceptor splice site at an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC109347, AF116612, AI246762, AI798931, BM823928, BU740563, BX498932, CN291547, DA463845

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    112231787..112273110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008378.2XP_016863867.1  AP-1 complex-associated regulatory protein isoform X1

    Conserved Domains (1) summary
    pfam15745
    Location:7247
    AP1AR; AP-1 complex-associated regulatory protein
  2. XM_017008379.2XP_016863868.1  AP-1 complex-associated regulatory protein isoform X2

    Conserved Domains (1) summary
    pfam15745
    Location:7214
    AP1AR; AP-1 complex-associated regulatory protein
  3. XM_017008380.1XP_016863869.1  AP-1 complex-associated regulatory protein isoform X3

    Conserved Domains (1) summary
    pfam15745
    Location:1142
    AP1AR; AP-1 complex-associated regulatory protein
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