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H4C15 H4 clustered histone 15 [ Homo sapiens (human) ]

Gene ID: 554313, updated on 29-Oct-2022

Summary

Official Symbol
H4C15provided by HGNC
Official Full Name
H4 clustered histone 15provided by HGNC
Primary source
HGNC:HGNC:29607
See related
Ensembl:ENSG00000270276 AllianceGenome:HGNC:29607
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H4/o; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4-16; H4C11; H4C12; H4C13; H4C14; H4C16; HIST2H4B
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H4 family. Some transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, May 2020]
Orthologs
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Genomic context

See H4C15 in Genome Data Viewer
Location:
1q21.2
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (149844488..149861240, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (148978230..148985305, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149825657..149832725, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H2A clustered histone 18 Neighboring gene H2B clustered histone 19, pseudogene Neighboring gene H2B clustered histone 20, pseudogene Neighboring gene H2A clustered histone 19 Neighboring gene H3 clustered histone 15 Neighboring gene H2B clustered histone 21 Neighboring gene H2A clustered histone 20

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H4
Names
histone 2, H4b
histone cluster 2 H4 family member b
histone cluster 2, H4b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034077.4NP_001029249.1  histone H4

    See identical proteins and their annotated locations for NP_001029249.1

    Status: REVIEWED

    Source sequence(s)
    AC239868
    Consensus CDS
    CCDS30851.1
    UniProtKB/Swiss-Prot
    P62805, Q6NWP7
    UniProtKB/TrEMBL
    B2R4R0
    Related
    ENSP00000462355.1, ENST00000579512.3
    Conserved Domains (1) summary
    PLN00035
    Location:1103
    PLN00035; histone H4; Provisional

RNA

  1. NR_168446.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC239868
  2. NR_168447.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC239868
  3. NR_168448.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC239868

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    149844488..149861240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424442.1XP_047280398.1  histone H4 isoform X1

    UniProtKB/Swiss-Prot
    Q6NWP7
    UniProtKB/TrEMBL
    B2R4R0
  2. XM_047424439.1XP_047280395.1  histone H4 isoform X1

    UniProtKB/Swiss-Prot
    Q6NWP7
    UniProtKB/TrEMBL
    B2R4R0
  3. XM_024451708.2XP_024307476.2  histone H4 isoform X1

    UniProtKB/Swiss-Prot
    Q6NWP7
    UniProtKB/TrEMBL
    B2R4R0
  4. XM_047424434.1XP_047280390.1  histone H4 isoform X1

    UniProtKB/Swiss-Prot
    Q6NWP7
    UniProtKB/TrEMBL
    B2R4R0
  5. XM_047424436.1XP_047280392.1  histone H4 isoform X1

    UniProtKB/Swiss-Prot
    Q6NWP7
    UniProtKB/TrEMBL
    B2R4R0
    Related
    ENSP00000482412.1, ENST00000612061.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    148978230..148985305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)