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ASPDH aspartate dehydrogenase domain containing [ Homo sapiens (human) ]

Gene ID: 554235, updated on 1-Jun-2020

Summary

Official Symbol
ASPDHprovided by HGNC
Official Full Name
aspartate dehydrogenase domain containingprovided by HGNC
Primary source
HGNC:HGNC:33856
See related
Ensembl:ENSG00000204653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in liver (RPKM 17.1), kidney (RPKM 16.9) and 2 other tissues See more
Orthologs

Genomic context

See ASPDH in Genome Data Viewer
Location:
19q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (50511600..50514684, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51014857..51018689, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 71 member E1 Neighboring gene ER membrane protein complex subunit 10 Neighboring gene Josephin domain containing 2 Neighboring gene leucine rich repeat containing 4B Neighboring gene CRISPRi-validated cis-regulatory element chr19.5650

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADP binding IEA
Inferred from Electronic Annotation
more info
 
aspartate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative L-aspartate dehydrogenase
Names
aspartate dehydrogenase domain-containing protein
NP_001019827.2
NP_001108070.1
XP_024307353.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024656.3NP_001019827.2  putative L-aspartate dehydrogenase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks several in-frame portions of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter, distinct N-terminus when compared to isoform 1. Isoform 2 lacks an N-terminus NAD-binding-3 domain, compared to isoform 1.
    Source sequence(s)
    BC066359, BM695973, BU729215
    Consensus CDS
    CCDS33082.1
    UniProtKB/Swiss-Prot
    A6ND91
    Related
    ENSP00000366114.2, ENST00000376916.7
    Conserved Domains (2) summary
    pfam01958
    Location:68156
    DUF108; Domain of unknown function DUF108
    cl21454
    Location:1235
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001114598.2NP_001108070.1  putative L-aspartate dehydrogenase isoform 1

    See identical proteins and their annotated locations for NP_001108070.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC008743, BM924033, BU729215
    Consensus CDS
    CCDS46153.1
    UniProtKB/Swiss-Prot
    A6ND91
    Related
    ENSP00000373860.3, ENST00000389208.9
    Conserved Domains (2) summary
    pfam01958
    Location:173261
    DUF108; Domain of unknown function DUF108
    pfam03447
    Location:13123
    NAD_binding_3; Homoserine dehydrogenase, NAD binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    50511600..50514684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451585.1XP_024307353.1  putative L-aspartate dehydrogenase isoform X1

    Conserved Domains (2) summary
    pfam03447
    Location:1390
    NAD_binding_3; Homoserine dehydrogenase, NAD binding domain
    pfam01958
    Location:123211
    DUF108; Domain of unknown function DUF108
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