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SIRPG signal regulatory protein gamma [ Homo sapiens (human) ]

Gene ID: 55423, updated on 11-Sep-2019

Summary

Official Symbol
SIRPGprovided by HGNC
Official Full Name
signal regulatory protein gammaprovided by HGNC
Primary source
HGNC:HGNC:15757
See related
Ensembl:ENSG00000089012 MIM:605466
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD172g; SIRPB2; SIRP-B2; bA77C3.1; SIRPgamma
Summary
The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 13.6), appendix (RPKM 6.0) and 8 other tissues See more
Orthologs

Genomic context

See SIRPG in Genome Data Viewer
Location:
20p13
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (1629152..1686516, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1609522..1638425, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985409 Neighboring gene signal regulatory protein beta 1 Neighboring gene SIRPG antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 561, pseudogene Neighboring gene signal regulatory protein beta 3, pseudogene Neighboring gene CKAP2L pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
NHGRI GWA Catalog

Pathways from BioSystems

  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Cell-Cell communication, organism-specific biosystem (from REACTOME)
    Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Signal regulatory protein (SIRP) family interactions, organism-specific biosystem (from REACTOME)
    Signal regulatory protein (SIRP) family interactions, organism-specific biosystemSignal regulatory protein (SIRP)alpha, also known as SHPS-1 or SIRPA or CD172a, is a transmembrane protein expressed mostly on myeloid cells. CD47, a widely expressed transmembrane protein, is a liga...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42230

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
signal-regulatory protein gamma
Names
CD172 antigen-like family member B
CD172g antigen
SIRP beta 2
SIRP-gamma
signal-regulatory protein beta-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039508.1NP_001034597.1  signal-regulatory protein gamma isoform 3 precursor

    See identical proteins and their annotated locations for NP_001034597.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal segment within the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AA446468, AY748247, BC064532, DA008008, DB046293
    Consensus CDS
    CCDS33434.1
    UniProtKB/Swiss-Prot
    Q9P1W8
    Related
    ENSP00000370995.2, ENST00000381583.6
    Conserved Domains (3) summary
    cd00099
    Location:41138
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:41120
    IG_like; Immunoglobulin like
    cl11960
    Location:144251
    Ig; Immunoglobulin domain
  2. NM_018556.4NP_061026.2  signal-regulatory protein gamma isoform 1 precursor

    See identical proteins and their annotated locations for NP_061026.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA446468, AY748247, BC064532, DA008008, DB046293
    Consensus CDS
    CCDS13020.2
    UniProtKB/Swiss-Prot
    Q9P1W8
    Related
    ENSP00000305529.3, ENST00000303415.7
    Conserved Domains (3) summary
    cd05772
    Location:145248
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:250353
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
    cd16097
    Location:33143
    IgV_SIRP; Immunoglobulin (Ig)-like domain of Signal-Regulatory Protein (SIRP)
  3. NM_080816.3NP_543006.2  signal-regulatory protein gamma isoform 2 precursor

    See identical proteins and their annotated locations for NP_543006.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two internal segments within the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA446468, AY748247, BC020629, BC064532, DA008008, DB046293
    Consensus CDS
    CCDS13021.2
    UniProtKB/Swiss-Prot
    Q9P1W8
    Related
    ENSP00000342759.4, ENST00000344103.8
    Conserved Domains (2) summary
    smart00410
    Location:41120
    IG_like; Immunoglobulin like
    pfam07686
    Location:36133
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    1629152..1686516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529286.2XP_011527588.1  signal-regulatory protein gamma isoform X1

    UniProtKB/Swiss-Prot
    Q9P1W8
    Related
    ENSP00000370992.1, ENST00000381580.5
    Conserved Domains (4) summary
    cd00098
    Location:231302
    IgC; Immunoglobulin Constant domain
    cd00099
    Location:8105
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:887
    IG_like; Immunoglobulin like
    cl11960
    Location:111219
    Ig; Immunoglobulin domain
  2. XM_005260749.4XP_005260806.1  signal-regulatory protein gamma isoform X2

    Conserved Domains (3) summary
    cd00098
    Location:158229
    IgC; Immunoglobulin Constant domain
    cd00099
    Location:41138
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:41120
    IG_like; Immunoglobulin like
  3. XM_011529287.2XP_011527589.1  signal-regulatory protein gamma isoform X3

    Conserved Domains (3) summary
    smart00410
    Location:41120
    IG_like; Immunoglobulin like
    pfam07686
    Location:36133
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:144249
    Ig; Immunoglobulin domain
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