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NCBP3 nuclear cap binding subunit 3 [ Homo sapiens (human) ]

Gene ID: 55421, updated on 5-Aug-2022

Summary

Official Symbol
NCBP3provided by HGNC
Official Full Name
nuclear cap binding subunit 3provided by HGNC
Primary source
HGNC:HGNC:24612
See related
Ensembl:ENSG00000074356 MIM:616624; AllianceGenome:HGNC:24612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ELG; C17orf85; HSA277841
Summary
Enables RNA 7-methylguanosine cap binding activity and mRNA binding activity. Involved in defense response to virus. Located in cytoplasm and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 6.9), placenta (RPKM 6.6) and 25 other tissues See more
Orthologs
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Genomic context

See NCBP3 in Genome Data Viewer
Location:
17p13.2
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (3802158..3846246, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (3690835..3734921, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3705452..3749540, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha E Neighboring gene Sharpr-MPRA regulatory region 669 Neighboring gene nonconserved acetylation island sequence 85 enhancer Neighboring gene uncharacterized LOC124903897 Neighboring gene calcium/calmodulin dependent protein kinase kinase 1 Neighboring gene Sharpr-MPRA regulatory region 11291

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32162

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA binding HDA PubMed 
enables RNA cap binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in 7-methylguanosine mRNA capping IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA transcription by RNA polymerase II IC
Inferred by Curator
more info
PubMed 
involved_in snRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RNA cap binding complex TAS
Traceable Author Statement
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of mRNA cap binding complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of nuclear cap binding complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear cap-binding protein subunit 3
Names
CTD-3195I5.1
CTD-3195I5.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114118.3NP_001107590.1  nuclear cap-binding protein subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_001107590.1

    Status: VALIDATED

    Source sequence(s)
    AC116914, AJ277841, BM974475, BP344033, DA403386, DA815746, KC877633, KC877636
    Consensus CDS
    CCDS45578.1
    UniProtKB/Swiss-Prot
    Q53F19, Q9NXZ4
    Related
    ENSP00000373657.4, ENST00000389005.6
    Conserved Domains (1) summary
    pfam10309
    Location:123177
    NCBP3; Nuclear cap-binding protein subunit 3
  2. NM_001398494.1NP_001385423.1  nuclear cap-binding protein subunit 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005940, AC116914, KC877633, KC877636
    Conserved Domains (1) summary
    pfam10309
    Location:123177
    NCBP3; Nuclear cap-binding protein subunit 3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    3802158..3846246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007065313.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    3690835..3734921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018553.3: Suppressed sequence

    Description
    NM_018553.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript is a candidate for nonsense-mediated mRNA decay (NMD) if the expected exon 1 start codon is used.