Format

Send to:

Choose Destination

NCBP3 nuclear cap binding subunit 3 [ Homo sapiens (human) ]

Gene ID: 55421, updated on 1-Jun-2020

Summary

Official Symbol
NCBP3provided by HGNC
Official Full Name
nuclear cap binding subunit 3provided by HGNC
Primary source
HGNC:HGNC:24612
See related
Ensembl:ENSG00000074356 MIM:616624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ELG; C17orf85; HSA277841
Expression
Ubiquitous expression in bone marrow (RPKM 6.9), placenta (RPKM 6.6) and 25 other tissues See more
Orthologs

Genomic context

See NCBP3 in Genome Data Viewer
Location:
17p13.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (3802158..3846246, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3710042..3749545, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha E Neighboring gene histone H3 associated protein kinase Neighboring gene nonconserved acetylation island sequence 85 enhancer Neighboring gene calcium/calmodulin dependent protein kinase kinase 1 Neighboring gene purinergic receptor P2X 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32162

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA 7-methylguanosine cap binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA binding HDA PubMed 
RNA cap binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
7-methylguanosine mRNA capping IEA
Inferred from Electronic Annotation
more info
 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA cap binding complex TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear cap-binding protein subunit 3
Names
CTD-3195I5.1
CTD-3195I5.5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114118.3NP_001107590.1  nuclear cap-binding protein subunit 3

    See identical proteins and their annotated locations for NP_001107590.1

    Status: VALIDATED

    Source sequence(s)
    AC116914, AJ277841, BM974475, BP344033, DA403386, DA815746, KC877633, KC877636
    Consensus CDS
    CCDS45578.1
    UniProtKB/Swiss-Prot
    Q53F19
    Related
    ENSP00000373657.4, ENST00000389005.6
    Conserved Domains (1) summary
    pfam10309
    Location:123177
    DUF2414; Protein of unknown function (DUF2414)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    3802158..3846246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256717.3XP_005256774.1  nuclear cap-binding protein subunit 3 isoform X1

    Conserved Domains (1) summary
    pfam10309
    Location:123177
    DUF2414; Protein of unknown function (DUF2414)
  2. XM_006721556.3XP_006721619.1  nuclear cap-binding protein subunit 3 isoform X3

    See identical proteins and their annotated locations for XP_006721619.1

    Conserved Domains (1) summary
    pfam10309
    Location:142
    DUF2414; Protein of unknown function (DUF2414)
  3. XM_011523955.3XP_011522257.1  nuclear cap-binding protein subunit 3 isoform X3

    See identical proteins and their annotated locations for XP_011522257.1

    Conserved Domains (1) summary
    pfam10309
    Location:142
    DUF2414; Protein of unknown function (DUF2414)
  4. XM_017024828.2XP_016880317.1  nuclear cap-binding protein subunit 3 isoform X5

  5. XM_017024827.2XP_016880316.1  nuclear cap-binding protein subunit 3 isoform X5

  6. XM_017024826.1XP_016880315.1  nuclear cap-binding protein subunit 3 isoform X4

  7. XM_011523954.3XP_011522256.1  nuclear cap-binding protein subunit 3 isoform X2

    Conserved Domains (1) summary
    pfam10309
    Location:963
    DUF2414; Protein of unknown function (DUF2414)
  8. XM_017024829.1XP_016880318.1  nuclear cap-binding protein subunit 3 isoform X6

    UniProtKB/Swiss-Prot
    Q53F19

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018553.3: Suppressed sequence

    Description
    NM_018553.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript is a candidate for nonsense-mediated mRNA decay (NMD) if the expected exon 1 start codon is used.
Support Center