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PRB1 proline rich protein BstNI subfamily 1 [ Homo sapiens (human) ]

Gene ID: 5542, updated on 7-Jun-2020

Summary

Official Symbol
PRB1provided by HGNC
Official Full Name
proline rich protein BstNI subfamily 1provided by HGNC
Primary source
HGNC:HGNC:9337
See related
Ensembl:ENSG00000251655 MIM:180989
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PM; PMF; PMS; PRB1L; PRB1M
Summary
This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature peptides before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Medium" allele. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]
Expression
Restricted expression toward salivary gland (RPKM 6228.4) See more
Orthologs

Genomic context

See PRB1 in Genome Data Viewer
Location:
12p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (11351821..11355590, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (11504757..11508524, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987183 Neighboring gene proline rich protein BstNI subfamily 4 Neighboring gene proline rich protein BstNI subfamily 2 Neighboring gene uncharacterized LOC440084 Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
basic salivary proline-rich protein 1
Names
BstNI type basic salivary proline-rich protein 1
parotid middle band protein
salivary protein Pe

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367912.1NP_001354841.1  basic salivary proline-rich protein 1 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an expanded repeat domain, and lacks the premature stop codon,compared to the haplotype on the reference genome. The encoded isoform (4) is longer than isoform 1
    Source sequence(s)
    AC238694
  2. NM_005039.3NP_005030.2  basic salivary proline-rich protein 1 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_005030.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AC010176, K03204
    UniProtKB/Swiss-Prot
    P04280

RNA

  1. NR_160307.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, non-coding) contains a polymorphic nt that creates an early termination codon compared to variant 1, coding. The resulting transcript is considered to be non-protein coding since it is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC010176
    Related
    ENST00000240636.10

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    11351821..11355590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187658.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    546784..550553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199353.2: Suppressed sequence

    Description
    NM_199353.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
  2. NM_199354.2: Suppressed sequence

    Description
    NM_199354.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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