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MCM10 minichromosome maintenance 10 replication initiation factor [ Homo sapiens (human) ]

Gene ID: 55388, updated on 13-Mar-2020

Summary

Official Symbol
MCM10provided by HGNC
Official Full Name
minichromosome maintenance 10 replication initiation factorprovided by HGNC
Primary source
HGNC:HGNC:18043
See related
Ensembl:ENSG00000065328 MIM:609357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNA43; DNA43; PRO2249
Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 2.8), lymph node (RPKM 2.2) and 15 other tissues See more
Orthologs

Genomic context

See MCM10 in Genome Data Viewer
Location:
10p13
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (13161558..13211110)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (13203554..13253104)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BTB domain containing 7 pseudogene 1 Neighboring gene ribosomal protein L36a pseudogene 36 Neighboring gene RNA, U6 small nuclear 6, pseudogene Neighboring gene upper zone of growth plate and cartilage matrix associated

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 depletes MCM10 in a Vpr-dependent manner PubMed
vpr HIV-1 Vpr enhances the proteasomal degradation of MCM10, (a natural substrate for the Cul4-DDB1[VprBP] E3 ubiquitin ligase whose degradation is regulated by VprBP), by interacting with VprBP PubMed
vpr HIV-1 Vpr degrades MCM10 via Cul4-DDB1 E3 ubiquitin ligase proteasomal degradation pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126776

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA replication TAS
Traceable Author Statement
more info
 
DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein MCM10 homolog
Names
MCM10 minichromosome maintenance deficient 10
homolog of yeast MCM10
hsMCM10
minichromosome maintenance complex component 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018518.5NP_060988.3  protein MCM10 homolog isoform 2

    See identical proteins and their annotated locations for NP_060988.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the predominant isoform (2).
    Source sequence(s)
    AB042719, AL136840, AL138764, DA024424
    Consensus CDS
    CCDS7095.1
    UniProtKB/Swiss-Prot
    Q7L590
    Related
    ENSP00000367986.3, ENST00000378714.7
    Conserved Domains (2) summary
    pfam09329
    Location:381426
    zf-primase; Primase zinc finger
    pfam09332
    Location:525872
    Mcm10; Mcm10 replication factor
  2. NM_182751.3NP_877428.1  protein MCM10 homolog isoform 1

    See identical proteins and their annotated locations for NP_877428.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses a different splice site, compared to variant 2, that results in a longer isoform (1). Though this variant is supported by EST data, the existence of its encoded isoform has not been experimentally verified.
    Source sequence(s)
    AB042719, AK055695, AL136840, AL138764, DA024424
    Consensus CDS
    CCDS7096.1
    UniProtKB/Swiss-Prot
    Q7L590
    Related
    ENSP00000418268.1, ENST00000484800.6
    Conserved Domains (2) summary
    pfam09329
    Location:382427
    zf-primase; Primase zinc finger
    pfam09332
    Location:526873
    Mcm10; Mcm10 replication factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    13161558..13211110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519538.2XP_011517840.1  protein MCM10 homolog isoform X1

    See identical proteins and their annotated locations for XP_011517840.1

    UniProtKB/Swiss-Prot
    Q7L590
    Conserved Domains (2) summary
    pfam09329
    Location:382427
    zf-primase; Primase zinc finger
    pfam09332
    Location:526873
    Mcm10; Mcm10 replication factor
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