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MEG3 maternally expressed 3 [ Homo sapiens (human) ]

Gene ID: 55384, updated on 25-Oct-2020

Summary

Official Symbol
MEG3provided by HGNC
Official Full Name
maternally expressed 3provided by HGNC
Primary source
HGNC:HGNC:14575
See related
Ensembl:ENSG00000214548 MIM:605636
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTL2; FP504; prebp1; PRO0518; PRO2160; LINC00023; NCRNA00023; onco-lncRNA-83
Summary
This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]
Expression
Biased expression in placenta (RPKM 89.5), adrenal (RPKM 54.9) and 6 other tissues See more
Orthologs

Genomic context

See MEG3 in Genome Data Viewer
Location:
14q32.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (100826108..100861026)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (101292445..101327363)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10698 Neighboring gene microRNA 2392 Neighboring gene microRNA 770 Neighboring gene microRNA 493 Neighboring gene microRNA 337

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
GeneReviews: Not available
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.
GeneReviews: Not available

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2012-04-25)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated (2012-04-25)

ClinGen Genome Curation PagePubMed

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Other Names

  • Very putative protein from MEG3 locus
  • long intergenic non-protein coding RNA 23
  • maternally expressed 3 (non-protein coding)

Clone Names

  • FLJ31163, FLJ42589, FLJ44703

Gene Ontology Provided by GOA

Process Evidence Code Pubs
gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016853.2 RefSeqGene

    Range
    51699..86617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_002766.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as MEG3) is the predominant transcript, consisting of seven exons.
    Source sequence(s)
    AL117190
    Related
    ENST00000451743.6
  2. NR_003530.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has two additional exons in an internal region, compared to variant 1.
    Source sequence(s)
    BQ270557, BX161452, DB449068
    Related
    ENST00000423456.6
  3. NR_003531.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as MEG3a) has an additional exon in an internal region, compared to variant 1.
    Source sequence(s)
    AB032607, AY314975
    Related
    ENST00000554639.5
  4. NR_033358.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an additional exon in an internal region, compared to variant 1.
    Source sequence(s)
    BQ270557, BX248012, DB449068
    Related
    ENST00000556736.5
  5. NR_033359.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in an internal region, compared to variant 1. It consists of eight exons.
    Source sequence(s)
    BQ270557, BX161432, DB449068
    Related
    ENST00000412736.7
  6. NR_033360.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as MEG3b) differs in an internal region, compared to variant 1. It consists of seven exons.
    Source sequence(s)
    BQ270557, BX247998, DB449068
    Related
    ENST00000429159.6
  7. NR_046464.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also known as MEG3c) differs in an internal region, compared to variant 1. It consists of eight exons.
    Source sequence(s)
    DB449068, GQ183495
  8. NR_046465.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8, also known as MEG3d) has an alternate site and is longer than variant 1.
    Source sequence(s)
    DB449068, GQ183496
    Related
    ENST00000648456.1
  9. NR_046466.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9, also known as MEG3e) lacks an internal exon, compared to variant 1.
    Source sequence(s)
    DB449068, GQ183497
    Related
    ENST00000521404.5
  10. NR_046467.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10, also known as MEG3f) has an additional segment and an additional exon in an internal region, compared to variant 1.
    Source sequence(s)
    DB449068, GQ183498
  11. NR_046469.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12, also known as MEG3h) differs in an internal region, compared to variant 1. It consists of seven exons.
    Source sequence(s)
    DB449068, GQ183500
  12. NR_046470.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13, also known as MEG3i) differs in an internal region, compared to variant 1. It consists of eight exons.
    Source sequence(s)
    DB449068, GQ183501
  13. NR_046471.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14, also known as MEG3j) differs in an internal region, compared to variant 1. It consists of six exons.
    Source sequence(s)
    DB449068, GQ183502
  14. NR_046472.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15, also known as MEG3k) differs in an internal region, compared to variant 1. It consists of seven exons.
    Source sequence(s)
    DB449068, GQ183503
  15. NR_046473.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) has an alternate and very long 3' exon, compared to variant 1.
    Source sequence(s)
    AB032607, AF052114, AL117190, BQ613976, DB449068

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    100826108..100861026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_046468.2: Suppressed sequence

    Description
    NR_046468.2: This RefSeq was removed because it is redundant with another reference sequence transcript.
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