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st8sia5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 [ Danio rerio (zebrafish) ]

Gene ID: 553754, updated on 9-Sep-2025
Official Symbol
st8sia5provided by ZNC
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-060322-8
See related
Ensembl:ENSDARG00000036584 AllianceGenome:ZFIN:ZDB-GENE-060322-8
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
siat 8E; st8Sia V
Summary
Predicted to enable alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Predicted to be involved in N-glycan processing; oligosaccharide metabolic process; and protein glycosylation. Predicted to be located in Golgi membrane. Is expressed in nervous system; otic vesicle; and unfertilized egg. Orthologous to human ST8SIA5 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See st8sia5 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 21 NC_133196.1 (6082372..6117679)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 21 NC_007132.7 (5209443..5244608)

Chromosome 21 - NC_133196.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD72 Neighboring gene small nucleolar RNA SNORD72 Neighboring gene ribosomal protein L37 Neighboring gene lipoxygenase homology PLAT domains 1a Neighboring gene proteasome 26S subunit, non-ATPase 5

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Developmental regulation of oligosialylation in zebrafish. Chang LY, et al. Glycoconj J, 2009 Apr. PMID 18704683
  2. Novel Zebrafish Mono-α2,8-sialyltransferase (ST8Sia VIII): An Evolutionary Perspective of α2,8-Sialylation. Chang LY, et al. Int J Mol Sci, 2019 Jan 31. PMID 30709055, Free PMC Article
  3. Molecular cloning and characterization of the expression pattern of the zebrafish alpha2, 8-sialyltransferases (ST8Sia) in the developing nervous system. Chang LY, et al. Glycoconj J, 2009 Apr. PMID 18642128
  4. Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies. Vanbeselaere J, et al. J Proteome Res, 2012 Apr 6. PMID 22352757
  5. Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Yamakawa N, et al. Nat Commun, 2018 Nov 7. PMID 30405127, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
alpha-2,8-sialyltransferase 8E
Names
alpha-2,8-sialyltransferase ST8Sia V
NP_001191083.1
NP_001191084.1
XP_005161038.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204154.1 → NP_001191083.1  alpha-2,8-sialyltransferase 8E isoform 1

    See identical proteins and their annotated locations for NP_001191083.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AM287264, JBMGRA010000021
    UniProtKB/TrEMBL
    A0A8M1P3M4, Q0P7H3
    Related
    ENSDARP00000093315.2, ENSDART00000102539.4
    Conserved Domains (1) summary
    pfam00777
    Location:153 → 406
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. NM_001204155.1 → NP_001191084.1  alpha-2,8-sialyltransferase 8E isoform 2

    See identical proteins and their annotated locations for NP_001191084.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region but maintains the reading frame compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AM287263, JBMGRA010000021
    UniProtKB/TrEMBL
    A0A8M1P2N3, Q0P7H4
    Related
    ENSDARP00000093312.1, ENSDART00000102536.2
    Conserved Domains (1) summary
    pfam00777
    Location:117 → 370
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133196.1 Reference GRCz12tu Primary Assembly

    Range
    6082372..6117679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160981.5 → XP_005161038.1  alpha-2,8-sialyltransferase 8E isoform X1

    UniProtKB/TrEMBL
    A0A8M2B7X1
    Conserved Domains (1) summary
    pfam00777
    Location:186 → 439
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_012396556.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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