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nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) [ Danio rerio (zebrafish) ]

Gene ID: 553740, updated on 14-Oct-2021

Summary

Official Symbol
nr3c1provided by ZNC
Official Full Name
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)provided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-503
See related
Ensembl:ENSDARG00000025032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gr; utut; utouto; fb13f09; wu:fb13f09; zgc:113038
Orthologs
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Genomic context

See nr3c1 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (23747183..23801389, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (23449938..23504144, complement)
103 previous assembly Zv9 (GCF_000002035.4) 14 NC_007125.5 (24650944..24705668, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene Nedd4 family interacting protein 1 Neighboring gene fibroblast growth factor 1a Neighboring gene potassium channel tetramerization domain containing 16a Neighboring gene SH3 domain containing ring finger 2

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC113038, MGC191720

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glucocorticoid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glucocorticoid receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcium ion import IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to cortisol stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within circadian behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucocorticoid mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glucocorticoid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular steroid hormone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within light adaption IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organismal response to stress IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within positive regulation of hypoxia-inducible factor-1alpha signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within proton export across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to cortisol IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to cortisol IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to dexamethasone IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to glucocorticoid IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sodium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020711.3NP_001018547.2  glucocorticoid receptor

    See identical proteins and their annotated locations for NP_001018547.2

    Status: VALIDATED

    Source sequence(s)
    BX470157
    UniProtKB/TrEMBL
    Q1XHK0
    Related
    ENSDARP00000054263.3, ENSDART00000054264.5
    Conserved Domains (3) summary
    cd06947
    Location:500744
    NR_LBD_GR_Like; Ligand binding domain of nuclear hormone receptors:glucocorticoid receptor, mineralocorticoid receptor , progesterone receptor, and androgen receptor
    cd07172
    Location:383460
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:18369
    GCR; Glucocorticoid receptor

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    23747183..23801389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394908.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    50305..104525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395314.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    227430..280441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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