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IMPACT impact RWD domain protein [ Homo sapiens (human) ]

Gene ID: 55364, updated on 7-Aug-2022

Summary

Official Symbol
IMPACTprovided by HGNC
Official Full Name
impact RWD domain proteinprovided by HGNC
Primary source
HGNC:HGNC:20387
See related
Ensembl:ENSG00000154059 MIM:615319; AllianceGenome:HGNC:20387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RWDD5
Summary
Predicted to enable actin binding activity and ribosome binding activity. Predicted to be involved in several processes, including GCN2-mediated signaling; cellular response to starvation; and negative regulation of nitrogen compound metabolic process. Predicted to be located in cytoplasm. Predicted to be part of polysome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 17.1), testis (RPKM 17.0) and 25 other tissues See more
Orthologs
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Genomic context

See IMPACT in Genome Data Viewer
Location:
18q11.2
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (24426670..24453531)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (24620981..24647841)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (22006634..22033495)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein like 1A Neighboring gene uncharacterized LOC124904267 Neighboring gene uncharacterized LOC124904268 Neighboring gene histamine receptor H4 Neighboring gene uncharacterized LOC105372026 Neighboring gene zinc finger protein 470 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33718

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in GCN2-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in cellular response to UV-C ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to acidic pH ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to amino acid starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to benomyl ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to hydrogen peroxide ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to leucine starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription from RNA polymerase II promoter in response to stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron projection extension ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of translational initiation in response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of polysome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein IMPACT
Names
Impact homolog
RWD domain containing 5
imprinted and ancient gene protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018439.4NP_060909.2  protein IMPACT

    Status: VALIDATED

    Source sequence(s)
    AC007922
    Consensus CDS
    CCDS11886.1
    UniProtKB/Swiss-Prot
    Q9H2X4
    Related
    ENSP00000284202.4, ENST00000284202.9
    Conserved Domains (2) summary
    smart00591
    Location:15115
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam01205
    Location:182289
    UPF0029; Uncharacterized protein family UPF0029

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    24426670..24453531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    24620981..24647841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)