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IMPACT impact RWD domain protein [ Homo sapiens (human) ]

Gene ID: 55364, updated on 27-Nov-2024

Summary

Official Symbol
IMPACTprovided by HGNC
Official Full Name
impact RWD domain proteinprovided by HGNC
Primary source
HGNC:HGNC:20387
See related
Ensembl:ENSG00000154059 MIM:615319; AllianceGenome:HGNC:20387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RWDD5
Summary
Predicted to enable protein sequestering activity. Predicted to be involved in several processes, including GCN2-mediated signaling; cellular response to amino acid starvation; and regulation of gene expression. Predicted to act upstream of or within negative regulation of protein phosphorylation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 17.1), testis (RPKM 17.0) and 25 other tissues See more
Orthologs
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Genomic context

See IMPACT in Genome Data Viewer
Location:
18q11.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (24426670..24453531)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (24620981..24647841)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (22006634..22033495)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein like 1A Neighboring gene uncharacterized LOC124904267 Neighboring gene uncharacterized LOC124904268 Neighboring gene Sharpr-MPRA regulatory region 8214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:21964078-21964578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:21964579-21965079 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9364 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:22005698-22006612 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:22006613-22007527 Neighboring gene MPRA-validated peak3074 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:22052464-22052964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9367 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13172 Neighboring gene histamine receptor H4 Neighboring gene uncharacterized LOC105372026 Neighboring gene zinc finger protein 470 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC33718

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein sequestering activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in GCN2-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in GCN2-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to amino acid starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron projection extension ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cytoplasmic translational initiation in response to stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein IMPACT
Names
Impact homolog
RWD domain containing 5
imprinted and ancient gene protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018439.4NP_060909.2  protein IMPACT

    Status: VALIDATED

    Source sequence(s)
    AC007922
    Consensus CDS
    CCDS11886.1
    UniProtKB/Swiss-Prot
    A8MXG0, Q49AM0, Q9H2X4, Q9P2X3
    UniProtKB/TrEMBL
    A0A3B3ITH3
    Related
    ENSP00000284202.4, ENST00000284202.9
    Conserved Domains (2) summary
    smart00591
    Location:15115
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam01205
    Location:182289
    UPF0029; Uncharacterized protein family UPF0029

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    24426670..24453531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    24620981..24647841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318780.1XP_054174755.1  protein IMPACT isoform X1