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TMEM63B transmembrane protein 63B [ Homo sapiens (human) ]

Gene ID: 55362, updated on 7-Jun-2020

Summary

Official Symbol
TMEM63Bprovided by HGNC
Official Full Name
transmembrane protein 63Bprovided by HGNC
Primary source
HGNC:HGNC:17735
See related
Ensembl:ENSG00000137216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C6orf110
Expression
Ubiquitous expression in lung (RPKM 21.2), testis (RPKM 16.9) and 25 other tissues See more
Orthologs

Genomic context

See TMEM63B in Genome Data Viewer
Location:
6p21.1
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (44126628..44155519)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (44094599..44123256)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929705 Neighboring gene Sharpr-MPRA regulatory region 2143 Neighboring gene ribosomal protein L29 pseudogene 16 Neighboring gene mitochondrial ribosomal protein L14 Neighboring gene uncharacterized LOC107986599 Neighboring gene calpain 11 Neighboring gene uncharacterized LOC105375072

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686N2275

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium activated cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
mechanosensitive ion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
osmolarity-sensing cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318792.1NP_001305721.1  CSC1-like protein 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL365192, BC022095, CR627460
    Consensus CDS
    CCDS34461.1
    UniProtKB/Swiss-Prot
    Q5T3F8
    Related
    ENSP00000259746.9, ENST00000259746.13
    Conserved Domains (5) summary
    COG5594
    Location:40830
    COG5594; Uncharacterized integral membrane protein [Function unknown]
    pfam02714
    Location:362706
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:52221
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:275343
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter
    cl10015
    Location:235281
    YjgF_YER057c_UK114_family; YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no ...
  2. NM_018426.3NP_060896.1  CSC1-like protein 2

    See identical proteins and their annotated locations for NP_060896.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC022095, DC408120
    Consensus CDS
    CCDS34461.1
    UniProtKB/Swiss-Prot
    Q5T3F8
    Related
    ENSP00000327154.6, ENST00000323267.11
    Conserved Domains (5) summary
    COG5594
    Location:40830
    COG5594; Uncharacterized integral membrane protein [Function unknown]
    pfam02714
    Location:362706
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:52221
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:275343
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter
    cl10015
    Location:235281
    YjgF_YER057c_UK114_family; YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    44126628..44155519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249211.3XP_005249268.1  CSC1-like protein 2 isoform X1

    Conserved Domains (5) summary
    COG5594
    Location:49839
    COG5594; Uncharacterized integral membrane protein [Function unknown]
    pfam02714
    Location:371715
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:61230
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:284352
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter
    cl10015
    Location:244290
    YjgF_YER057c_UK114_family; YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no ...
  2. XM_005249213.4XP_005249270.1  CSC1-like protein 2 isoform X2

    See identical proteins and their annotated locations for XP_005249270.1

    UniProtKB/Swiss-Prot
    Q5T3F8
    Conserved Domains (5) summary
    COG5594
    Location:40830
    COG5594; Uncharacterized integral membrane protein [Function unknown]
    pfam02714
    Location:362706
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:52221
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:275343
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter
    cl10015
    Location:235281
    YjgF_YER057c_UK114_family; YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no ...
  3. XM_024446482.1XP_024302250.1  CSC1-like protein 2 isoform X4

    Conserved Domains (3) summary
    pfam02714
    Location:420691
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:52208
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:227409
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter
  4. XM_017011000.1XP_016866489.1  CSC1-like protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q5T3F8
    Conserved Domains (5) summary
    COG5594
    Location:40830
    COG5594; Uncharacterized integral membrane protein [Function unknown]
    pfam02714
    Location:362706
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:52221
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:275343
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter
    cl10015
    Location:235281
    YjgF_YER057c_UK114_family; YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no ...
  5. XM_005249215.4XP_005249272.1  CSC1-like protein 2 isoform X4

    See identical proteins and their annotated locations for XP_005249272.1

    Conserved Domains (3) summary
    pfam02714
    Location:420691
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:52208
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:227409
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter
  6. XM_017010999.1XP_016866488.1  CSC1-like protein 2 isoform X1

    Conserved Domains (5) summary
    COG5594
    Location:49839
    COG5594; Uncharacterized integral membrane protein [Function unknown]
    pfam02714
    Location:371715
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:61230
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:284352
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter
    cl10015
    Location:244290
    YjgF_YER057c_UK114_family; YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no ...
  7. XM_017011001.1XP_016866490.1  CSC1-like protein 2 isoform X4

    Related
    ENSP00000360960.2, ENST00000371893.6
    Conserved Domains (3) summary
    pfam02714
    Location:420691
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:52208
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:227409
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter
  8. XM_006715135.1XP_006715198.1  CSC1-like protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006715198.1

    UniProtKB/Swiss-Prot
    Q5T3F8
    Conserved Domains (5) summary
    COG5594
    Location:40830
    COG5594; Uncharacterized integral membrane protein [Function unknown]
    pfam02714
    Location:362706
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:52221
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:275343
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter
    cl10015
    Location:235281
    YjgF_YER057c_UK114_family; YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no ...
  9. XM_017011002.1XP_016866491.1  CSC1-like protein 2 isoform X4

    Conserved Domains (3) summary
    pfam02714
    Location:420691
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:52208
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:227409
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter
  10. XM_005249217.1XP_005249274.1  CSC1-like protein 2 isoform X2

    See identical proteins and their annotated locations for XP_005249274.1

    UniProtKB/Swiss-Prot
    Q5T3F8
    Conserved Domains (5) summary
    COG5594
    Location:40830
    COG5594; Uncharacterized integral membrane protein [Function unknown]
    pfam02714
    Location:362706
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:52221
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:275343
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter
    cl10015
    Location:235281
    YjgF_YER057c_UK114_family; YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no ...
  11. XM_005249214.4XP_005249271.1  CSC1-like protein 2 isoform X3

    Conserved Domains (5) summary
    COG5594
    Location:49826
    COG5594; Uncharacterized integral membrane protein [Function unknown]
    pfam02714
    Location:358702
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:61217
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:271339
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter
    cl10015
    Location:231277
    YjgF_YER057c_UK114_family; YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no ...

RNA

  1. XR_001743506.2 RNA Sequence

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