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alox5b.3 arachidonate 5-lipoxygenase b, tandem duplicate 3 [ Danio rerio (zebrafish) ]

Gene ID: 553602, updated on 11-Dec-2022

Summary

Official Symbol
alox5b.3provided by ZNC
Official Full Name
arachidonate 5-lipoxygenase b, tandem duplicate 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-330
See related
Ensembl:ENSDARG00000069966 AllianceGenome:ZFIN:ZDB-GENE-050522-330
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb171; sb:cb171; zgc:110251
Summary
Predicted to enable arachidonate 5-lipoxygenase activity. Predicted to be involved in fatty acid metabolic process and lipid oxidation. Predicted to be located in cytoplasm. Predicted to be active in nuclear envelope. Is expressed in EVL and periderm. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See alox5b.3 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (592253..604340, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (631450..643548, complement)
103 previous assembly Zv9 (GCF_000002035.4) 15 NC_007126.5 (591144..603243, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene si:ch73-144d13.4 Neighboring gene si:ch73-144d13.5 Neighboring gene si:ch73-144d13.7 Neighboring gene zinc finger protein 585A-like

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Clone Names

  • MGC110251

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables arachidonate 5-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in linoleic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipid oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
arachidonate 5-lipoxygenase b, tandem duplicate 3; uncharacterized protein LOC553602
Names
ALOX3c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020578.1NP_001018414.1  arachidonate 5-lipoxygenase b, tandem duplicate 3

    See identical proteins and their annotated locations for NP_001018414.1

    Status: PROVISIONAL

    Source sequence(s)
    BC095211
    UniProtKB/TrEMBL
    Q503R7
    Related
    ENSDARP00000093033.2, ENSDART00000102257.4
    Conserved Domains (2) summary
    pfam00305
    Location:226667
    Lipoxygenase; Lipoxygenase
    cl00011
    Location:3115
    PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    592253..604340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005169640.4XP_005169697.1  uncharacterized protein LOC553602 isoform X1

    See identical proteins and their annotated locations for XP_005169697.1

    UniProtKB/TrEMBL
    A0A8M2BH25, F1R442
    Conserved Domains (2) summary
    pfam00305
    Location:226667
    Lipoxygenase; Lipoxygenase
    cl00011
    Location:3115
    PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...