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STYK1 serine/threonine/tyrosine kinase 1 [ Homo sapiens (human) ]

Gene ID: 55359, updated on 17-Jun-2024

Summary

Official Symbol
STYK1provided by HGNC
Official Full Name
serine/threonine/tyrosine kinase 1provided by HGNC
Primary source
HGNC:HGNC:18889
See related
Ensembl:ENSG00000060140 MIM:611433; AllianceGenome:HGNC:18889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOK; SuRTK106
Summary
Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in colon (RPKM 5.3), stomach (RPKM 4.5) and 13 other tissues See more
Orthologs
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Genomic context

See STYK1 in Genome Data Viewer
Location:
12p13.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10618923..10674052, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10492227..10547157, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10771522..10826651, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2446 Neighboring gene uncharacterized LOC105376675 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:10724334-10724939 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:10733376-10734575 Neighboring gene killer cell lectin like receptor A1, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr12:10765265-10766144 and GRCh37_chr12:10766145-10767022 Neighboring gene mago homolog B, exon junction complex subunit Neighboring gene Y-box binding protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4238 Neighboring gene uncharacterized LOC124902876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4240 Neighboring gene uncharacterized LOC112268104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5963

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp761P1010

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tyrosine-protein kinase STYK1
Names
novel oncogene with kinase domain
protein PK-unique
NP_060893.2
XP_005253474.1
XP_011519038.1
XP_011519039.1
XP_011519040.1
XP_047285055.1
XP_054228427.1
XP_054228428.1
XP_054228429.1
XP_054228430.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018423.3NP_060893.2  tyrosine-protein kinase STYK1

    See identical proteins and their annotated locations for NP_060893.2

    Status: VALIDATED

    Source sequence(s)
    AC021049, AF251059, AL353940
    Consensus CDS
    CCDS8629.1
    UniProtKB/Swiss-Prot
    B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
    UniProtKB/TrEMBL
    A0A0C5BIK5
    Related
    ENSP00000075503.3, ENST00000075503.8
    Conserved Domains (2) summary
    pfam07714
    Location:117380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118381
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    10618923..10674052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253417.3XP_005253474.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_005253474.1

    UniProtKB/Swiss-Prot
    B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
    UniProtKB/TrEMBL
    A0A0C5BIK5
    Conserved Domains (2) summary
    pfam07714
    Location:117380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118381
    PKc_like; Protein Kinases, catalytic domain
  2. XM_047429099.1XP_047285055.1  tyrosine-protein kinase STYK1 isoform X2

    UniProtKB/TrEMBL
    A0A0C5BIK5
  3. XM_011520736.2XP_011519038.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_011519038.1

    UniProtKB/Swiss-Prot
    B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
    UniProtKB/TrEMBL
    A0A0C5BIK5
    Conserved Domains (2) summary
    pfam07714
    Location:117380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118381
    PKc_like; Protein Kinases, catalytic domain
  4. XM_011520738.3XP_011519040.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_011519040.1

    UniProtKB/Swiss-Prot
    B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
    UniProtKB/TrEMBL
    A0A0C5BIK5
    Conserved Domains (2) summary
    pfam07714
    Location:117380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118381
    PKc_like; Protein Kinases, catalytic domain
  5. XM_011520737.2XP_011519039.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_011519039.1

    UniProtKB/Swiss-Prot
    B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
    UniProtKB/TrEMBL
    A0A0C5BIK5
    Conserved Domains (2) summary
    pfam07714
    Location:117380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118381
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    10492227..10547157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372452.1XP_054228427.1  tyrosine-protein kinase STYK1 isoform X1

    UniProtKB/TrEMBL
    A0A0C5BIK5
  2. XM_054372455.1XP_054228430.1  tyrosine-protein kinase STYK1 isoform X2

    UniProtKB/TrEMBL
    A0A0C5BIK5
  3. XM_054372453.1XP_054228428.1  tyrosine-protein kinase STYK1 isoform X1

    UniProtKB/TrEMBL
    A0A0C5BIK5
  4. XM_054372454.1XP_054228429.1  tyrosine-protein kinase STYK1 isoform X1

    UniProtKB/TrEMBL
    A0A0C5BIK5