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STYK1 serine/threonine/tyrosine kinase 1 [ Homo sapiens (human) ]

Gene ID: 55359, updated on 24-Nov-2020

Summary

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Official Symbol
STYK1provided by HGNC
Official Full Name
serine/threonine/tyrosine kinase 1provided by HGNC
Primary source
HGNC:HGNC:18889
See related
Ensembl:ENSG00000060140 MIM:611433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOK; SuRTK106
Summary
Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in colon (RPKM 5.3), stomach (RPKM 4.5) and 13 other tissues See more
Orthologs
mouse all

Genomic context

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See STYK1 in Genome Data Viewer
Location:
12p13.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (10618923..10674318, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10771538..10826917, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene killer cell lectin like receptor A1, pseudogene Neighboring gene mago homolog B, exon junction complex subunit Neighboring gene Y-box binding protein 3 Neighboring gene uncharacterized LOC112268104

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. STYK1/NOK correlates with ferroptosis in non-small cell lung carcinoma. Lai Y, et al. Biochem Biophys Res Commun, 2019 Nov 19. PMID 31542233
  2. STYK1 promotes tumor growth and metastasis by reducing SPINT2/HAI-2 expression in non-small cell lung cancer. Ma Z, et al. Cell Death Dis, 2019 Jun 4. PMID 31164631, Free PMC Article
  3. STYK1 promotes cancer cell proliferation and malignant transformation by activating PI3K-AKT pathway in gallbladder carcinoma. Hu YP, et al. Int J Biochem Cell Biol, 2018 Apr. PMID 29413947
  4. STYK1 promotes Warburg effect through PI3K/AKT signaling and predicts a poor prognosis in nasopharyngeal carcinoma. Zhao Y, et al. Tumour Biol, 2017 Jul. PMID 28720063
  5. Knockdown of Serine Threonine Tyrosine Kinase 1 (STYK1) Inhibits the Migration and Tumorigenesis in Glioma Cells. Zhou J, et al. Oncol Res, 2017 Jul 5. PMID 27983928

See all (39) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SMAD3 induces the transcription of STYK1 to promote epithelial-mesenchymal transition and to elicit paclitaxel resistance of ovarian cancer cells.
    Title: SMAD3 inducing the transcription of  STYK1 to promote the EMT process and improve the tolerance of ovarian carcinoma cells to paclitaxel.
  2. elevated serine threonine tyrosine kinase 1 (STYK1) or decreased serine peptidase inhibitor Kunitz type 2 (SPINT2/HAI-2) expression significantly correlated with poor prognosis, tumor invasion, and metastasis of NSCLC patients. STYK1 overexpression promoted NSCLC cells proliferation, migration, and invasion. STYK1 also induced epithelial-mesenchymal transition by E-cadherin downregulation and Snail upregulation.
    Title: STYK1 promotes tumor growth and metastasis by reducing SPINT2/HAI-2 expression in non-small cell lung cancer.
  3. Data suggest that regulating ferroptosis could be another cancerous mechanism of serine/threonine/tyrosine kinase 1 (STYK1).
    Title: STYK1/NOK correlates with ferroptosis in non-small cell lung carcinoma.
  4. findings suggest that STYK1 is a critical regulator of tumor growth and metastasis.
    Title: STYK1 promotes cancer cell proliferation and malignant transformation by activating PI3K-AKT pathway in gallbladder carcinoma.
  5. Overexpression of STYK1 was significantly associated with increased cell proliferation, migratory capability, and invasive capability in vitro, as well as increased volume of tumor, weight of tumor, and number of pulmonary metastasesin hepatocellular carcinoma.
    Title: STYK1 promotes epithelial-mesenchymal transition and tumor metastasis in human hepatocellular carcinoma through MEK/ERK and PI3K/AKT signaling.
  6. STYK1 plays an important role in glioma development and progression.
    Title: Knockdown of Serine Threonine Tyrosine Kinase 1 (STYK1) Inhibits the Migration and Tumorigenesis in Glioma Cells.
  7. Findings show that serine-threonine-tyrosine kinase 1 (NOK) mediates glycolysis and nuclear pyruvate dehydrogenase complex (PDC) associated histone acetylation.
    Title: NOK mediates glycolysis and nuclear PDC associated histone acetylation.
  8. Survival analysis reveals that STYK1 level is an independent prognostic factor for nasopharyngeal carcinoma patients. Our results indicate that STYK1 is a promising therapeutic target in nasopharyngeal carcinoma
    Title: STYK1 promotes Warburg effect through PI3K/AKT signaling and predicts a poor prognosis in nasopharyngeal carcinoma.
  9. Thus, our results reveal a novel tumorigenic function of NOK to mediate the genesis and remodeling of blood and lymphatic vessels during tumor progression.
    Title: NOK/STYK1 promotes the genesis and remodeling of blood and lymphatic vessels during tumor progression.
  10. High STYK1 expression is associated with intrahepatic cholangiocarcinoma.
    Title: Depletion of STYK1 inhibits intrahepatic cholangiocarcinoma development both in vitro and in vivo.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp761P1010

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
  
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
  
plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase STYK1
Names
novel oncogene with kinase domain
protein PK-unique
NP_060893.2
XP_005253474.1
XP_011519038.1
XP_011519039.1
XP_011519040.1
XP_016875068.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018423.3 → NP_060893.2  tyrosine-protein kinase STYK1

    See identical proteins and their annotated locations for NP_060893.2

    Status: VALIDATED

    Source sequence(s)
    AC021049, AF251059, AL353940
    Consensus CDS
    CCDS8629.1
    UniProtKB/Swiss-Prot
    Q6J9G0
    Related
    ENSP00000075503.3, ENST00000075503.8
    Conserved Domains (2) summary
    pfam07714
    Location:117 → 380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118 → 381
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    10618923..10674318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253417.2 → XP_005253474.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_005253474.1

    UniProtKB/Swiss-Prot
    Q6J9G0
    Conserved Domains (2) summary
    pfam07714
    Location:117 → 380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118 → 381
    PKc_like; Protein Kinases, catalytic domain

  2. XM_017019579.1 → XP_016875068.1  tyrosine-protein kinase STYK1 isoform X2

  3. XM_011520736.1 → XP_011519038.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_011519038.1

    UniProtKB/Swiss-Prot
    Q6J9G0
    Conserved Domains (2) summary
    pfam07714
    Location:117 → 380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118 → 381
    PKc_like; Protein Kinases, catalytic domain

  4. XM_011520738.2 → XP_011519040.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_011519040.1

    UniProtKB/Swiss-Prot
    Q6J9G0
    Conserved Domains (2) summary
    pfam07714
    Location:117 → 380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118 → 381
    PKc_like; Protein Kinases, catalytic domain

  5. XM_011520737.2 → XP_011519039.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_011519039.1

    UniProtKB/Swiss-Prot
    Q6J9G0
    Conserved Domains (2) summary
    pfam07714
    Location:117 → 380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118 → 381
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6J9G0.4 GenPept UniProtKB/Swiss-Prot:Q6J9G0

Gene LinkOut

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