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STYK1 serine/threonine/tyrosine kinase 1 [ Homo sapiens (human) ]

Gene ID: 55359, updated on 3-Mar-2026
Official Symbol
STYK1provided by HGNC
Official Full Name
serine/threonine/tyrosine kinase 1provided by HGNC
Primary source
HGNC:HGNC:18889
See related
Ensembl:ENSG00000060140 MIM:611433; AllianceGenome:HGNC:18889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOK; SuRTK106
Summary
Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in colon (RPKM 5.3), stomach (RPKM 4.5) and 13 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See STYK1 in Genome Data Viewer
Location:
12p13.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10618923..10674052, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10492227..10547157, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10771522..10826651, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2446 Neighboring gene uncharacterized LOC105376675 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:10724334-10724939 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:10733376-10734575 Neighboring gene killer cell lectin like receptor A1, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr12:10765265-10766144 and GRCh37_chr12:10766145-10767022 Neighboring gene mago homolog B, exon junction complex subunit Neighboring gene Y-box binding protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4238 Neighboring gene uncharacterized LOC124902876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4240 Neighboring gene uncharacterized LOC112268104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5963

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Diagnostic relevance of overexpressed serine threonine tyrosine kinase/novel oncogene with kinase domain (STYK1/ NOK) mRNA in colorectal cancer. Orang AV, et al. Asian Pac J Cancer Prev, 2014. PMID 25169509
  2. High Novel Oncogene with Kinase-Domain (NOK) Gene Expression is Associated with the Progression of Renal Cell Carcinoma. Cao Q, et al. Clin Lab, 2016. PMID 27012048
  3. NOK/STYK1 promotes the genesis and remodeling of blood and lymphatic vessels during tumor progression. Liu Y, et al. Biochem Biophys Res Commun, 2016 Sep 9. PMID 27444381
  4. Depletion of STYK1 inhibits intrahepatic cholangiocarcinoma development both in vitro and in vivo. Chen MY, et al. Tumour Biol, 2016 Oct. PMID 27542675
  5. STYK1 promotes epithelial-mesenchymal transition and tumor metastasis in human hepatocellular carcinoma through MEK/ERK and PI3K/AKT signaling. Wang Z, et al. Sci Rep, 2016 Sep 15. PMID 27628214, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Induction of chronic lymphocytic leukemia-like disease in STYK1/NOK transgenic mice.
    Title: Induction of chronic lymphocytic leukemia-like disease in STYK1/NOK transgenic mice.
  2. NOK associates with c-Src and promotes c-Src-induced STAT3 activation and cell proliferation.
    Title: NOK associates with c-Src and promotes c-Src-induced STAT3 activation and cell proliferation.
  3. STYK1 promotes the malignant progression of laryngeal squamous cell carcinoma through targeting TGF-beta1.
    Title: STYK1 promotes the malignant progression of laryngeal squamous cell carcinoma through targeting TGF-β1.
  4. SMAD3 induces the transcription of STYK1 to promote epithelial-mesenchymal transition and to elicit paclitaxel resistance of ovarian cancer cells.
    Title: SMAD3 inducing the transcription of  STYK1 to promote the EMT process and improve the tolerance of ovarian carcinoma cells to paclitaxel.
  5. elevated serine threonine tyrosine kinase 1 (STYK1) or decreased serine peptidase inhibitor Kunitz type 2 (SPINT2/HAI-2) expression significantly correlated with poor prognosis, tumor invasion, and metastasis of NSCLC patients. STYK1 overexpression promoted NSCLC cells proliferation, migration, and invasion. STYK1 also induced epithelial-mesenchymal transition by E-cadherin downregulation and Snail upregulation.
    Title: STYK1 promotes tumor growth and metastasis by reducing SPINT2/HAI-2 expression in non-small cell lung cancer.
  6. Data suggest that regulating ferroptosis could be another cancerous mechanism of serine/threonine/tyrosine kinase 1 (STYK1).
    Title: STYK1/NOK correlates with ferroptosis in non-small cell lung carcinoma.
  7. findings suggest that STYK1 is a critical regulator of tumor growth and metastasis.
    Title: STYK1 promotes cancer cell proliferation and malignant transformation by activating PI3K-AKT pathway in gallbladder carcinoma.
  8. Overexpression of STYK1 was significantly associated with increased cell proliferation, migratory capability, and invasive capability in vitro, as well as increased volume of tumor, weight of tumor, and number of pulmonary metastasesin hepatocellular carcinoma.
    Title: STYK1 promotes epithelial-mesenchymal transition and tumor metastasis in human hepatocellular carcinoma through MEK/ERK and PI3K/AKT signaling.
  9. STYK1 plays an important role in glioma development and progression.
    Title: Knockdown of Serine Threonine Tyrosine Kinase 1 (STYK1) Inhibits the Migration and Tumorigenesis in Glioma Cells.
  10. Findings show that serine-threonine-tyrosine kinase 1 (NOK) mediates glycolysis and nuclear pyruvate dehydrogenase complex (PDC) associated histone acetylation.
    Title: NOK mediates glycolysis and nuclear PDC associated histone acetylation.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp761P1010

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
Preferred Names
tyrosine-protein kinase STYK1
Names
novel oncogene with kinase domain
protein PK-unique
NP_060893.2
XP_005253474.1
XP_011519038.1
XP_011519039.1
XP_011519040.1
XP_047285055.1
XP_054228427.1
XP_054228428.1
XP_054228429.1
XP_054228430.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018423.3 → NP_060893.2  tyrosine-protein kinase STYK1

    See identical proteins and their annotated locations for NP_060893.2

    Status: VALIDATED

    Source sequence(s)
    AC021049, AF251059, AL353940
    Consensus CDS
    CCDS8629.1
    UniProtKB/Swiss-Prot
    B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
    UniProtKB/TrEMBL
    A0A0C5BIK5
    Related
    ENSP00000075503.3, ENST00000075503.8
    Conserved Domains (2) summary
    pfam07714
    Location:117 → 380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118 → 381
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    10618923..10674052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253417.3 → XP_005253474.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_005253474.1

    UniProtKB/Swiss-Prot
    B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
    UniProtKB/TrEMBL
    A0A0C5BIK5
    Related
    ENSP00000548997.1, ENST00000878938.1
    Conserved Domains (2) summary
    pfam07714
    Location:117 → 380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118 → 381
    PKc_like; Protein Kinases, catalytic domain

  2. XM_047429099.1 → XP_047285055.1  tyrosine-protein kinase STYK1 isoform X2

    UniProtKB/TrEMBL
    A0A0C5BIK5

  3. XM_011520736.2 → XP_011519038.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_011519038.1

    UniProtKB/Swiss-Prot
    B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
    UniProtKB/TrEMBL
    A0A0C5BIK5
    Related
    ENSP00000548996.1, ENST00000878937.1
    Conserved Domains (2) summary
    pfam07714
    Location:117 → 380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118 → 381
    PKc_like; Protein Kinases, catalytic domain

  4. XM_011520738.3 → XP_011519040.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_011519040.1

    UniProtKB/Swiss-Prot
    B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
    UniProtKB/TrEMBL
    A0A0C5BIK5
    Conserved Domains (2) summary
    pfam07714
    Location:117 → 380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118 → 381
    PKc_like; Protein Kinases, catalytic domain

  5. XM_011520737.2 → XP_011519039.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_011519039.1

    UniProtKB/Swiss-Prot
    B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
    UniProtKB/TrEMBL
    A0A0C5BIK5
    Conserved Domains (2) summary
    pfam07714
    Location:117 → 380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118 → 381
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    10492227..10547157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372452.1 → XP_054228427.1  tyrosine-protein kinase STYK1 isoform X1

    UniProtKB/TrEMBL
    A0A0C5BIK5

  2. XM_054372455.1 → XP_054228430.1  tyrosine-protein kinase STYK1 isoform X2

    UniProtKB/TrEMBL
    A0A0C5BIK5

  3. XM_054372453.1 → XP_054228428.1  tyrosine-protein kinase STYK1 isoform X1

    UniProtKB/TrEMBL
    A0A0C5BIK5

  4. XM_054372454.1 → XP_054228429.1  tyrosine-protein kinase STYK1 isoform X1

    UniProtKB/TrEMBL
    A0A0C5BIK5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6J9G0.4 GenPept UniProtKB/Swiss-Prot:Q6J9G0

Gene LinkOut

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