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STYK1 serine/threonine/tyrosine kinase 1 [ Homo sapiens (human) ]

Gene ID: 55359, updated on 15-Jun-2019

Summary

Official Symbol
STYK1provided by HGNC
Official Full Name
serine/threonine/tyrosine kinase 1provided by HGNC
Primary source
HGNC:HGNC:18889
See related
Ensembl:ENSG00000060140 MIM:611433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOK; SuRTK106
Summary
Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in colon (RPKM 5.3), stomach (RPKM 4.5) and 13 other tissues See more
Orthologs

Genomic context

See STYK1 in Genome Data Viewer
Location:
12p13.2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (10618923..10674318, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10771538..10826917, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene killer cell lectin like receptor A1, pseudogene Neighboring gene mago homolog B, exon junction complex subunit Neighboring gene Y-box binding protein 3 Neighboring gene uncharacterized LOC112268104

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761P1010

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tyrosine-protein kinase STYK1
Names
novel oncogene with kinase domain
protein PK-unique
NP_060893.2
XP_005253474.1
XP_011519038.1
XP_011519039.1
XP_011519040.1
XP_016875068.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018423.3NP_060893.2  tyrosine-protein kinase STYK1

    See identical proteins and their annotated locations for NP_060893.2

    Status: VALIDATED

    Source sequence(s)
    AC021049, AF251059, AL353940
    Consensus CDS
    CCDS8629.1
    UniProtKB/Swiss-Prot
    Q6J9G0
    Related
    ENSP00000075503.3, ENST00000075503.8
    Conserved Domains (2) summary
    pfam07714
    Location:117380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118381
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    10618923..10674318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253417.2XP_005253474.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_005253474.1

    UniProtKB/Swiss-Prot
    Q6J9G0
    Conserved Domains (2) summary
    pfam07714
    Location:117380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118381
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017019579.1XP_016875068.1  tyrosine-protein kinase STYK1 isoform X2

  3. XM_011520736.1XP_011519038.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_011519038.1

    UniProtKB/Swiss-Prot
    Q6J9G0
    Conserved Domains (2) summary
    pfam07714
    Location:117380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118381
    PKc_like; Protein Kinases, catalytic domain
  4. XM_011520738.2XP_011519040.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_011519040.1

    UniProtKB/Swiss-Prot
    Q6J9G0
    Conserved Domains (2) summary
    pfam07714
    Location:117380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118381
    PKc_like; Protein Kinases, catalytic domain
  5. XM_011520737.2XP_011519039.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_011519039.1

    UniProtKB/Swiss-Prot
    Q6J9G0
    Conserved Domains (2) summary
    pfam07714
    Location:117380
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:118381
    PKc_like; Protein Kinases, catalytic domain
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