U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HJURP Holliday junction recognition protein [ Homo sapiens (human) ]

Gene ID: 55355, updated on 6-Jul-2025
Official Symbol
HJURPprovided by HGNC
Official Full Name
Holliday junction recognition proteinprovided by HGNC
Primary source
HGNC:HGNC:25444
See related
Ensembl:ENSG00000123485 MIM:612667; AllianceGenome:HGNC:25444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAKTS; URLC9; hFLEG1
Summary
Enables histone binding activity and identical protein binding activity. Involved in CENP-A containing chromatin assembly; chromosome segregation; and regulation of protein-containing complex assembly. Located in cytosol; kinetochore; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in bone marrow (RPKM 15.6), testis (RPKM 7.0) and 11 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table
See HJURP in Genome Data Viewer
Location:
2q37.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (233836702..233854535, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (234325468..234351509, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (234745348..234763181, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 1 member A complex locus Neighboring gene UDP glucuronosyltransferase family 1 member A8 Neighboring gene UDP glucuronosyltransferase family 1 member A10 Neighboring gene UDP glucuronosyltransferase family 1 member A9 Neighboring gene UDP glucuronosyltransferase family 1 member A7 Neighboring gene UDP glucuronosyltransferase family 1 member A6 Neighboring gene UDP glucuronosyltransferase family 1 member A5 Neighboring gene UDP glucuronosyltransferase family 1 member A4 Neighboring gene UDP glucuronosyltransferase family 1 member A3 Neighboring gene UDP glucuronosyltransferase family 1 member A1 Neighboring gene maestro heat like repeat family member 2A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:234731477-234731977 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:234759038-234759538 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:234763063-234764055 Neighboring gene MSL complex subunit 3B Neighboring gene transient receptor potential cation channel subfamily M member 8 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:234882993-234884192 Neighboring gene Sharpr-MPRA regulatory region 7512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17351 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:234920120-234920398

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Holliday junction recognition protein as a prognostic biomarker and therapeutic target for oral cancer. Tsevegjav B, et al. Int J Oncol, 2022 Mar. PMID 35103286
  2. Holliday junction‑recognition protein modulates apoptosis, cell cycle arrest and reactive oxygen species stress in human renal cell carcinoma. Yuan JS, et al. Oncol Rep, 2020 Sep. PMID 32582972
  3. Prognostic Relevance of HJURP Expression in Patients with Surgically Resected Colorectal Cancer. Kang DH, et al. Int J Mol Sci, 2020 Oct 26. PMID 33114545, Free PMC Article
  4. HJURP knockdown disrupts clonogenic capacity and increases radiation-induced cell death of glioblastoma cells. Serafim RB, et al. Cancer Gene Ther, 2020 May. PMID 31138900
  5. Knockdown of HJURP inhibits non-small cell lung cancer cell proliferation, migration, and invasion by repressing Wnt/β-catenin signaling. Wei Y, et al. Eur Rev Med Pharmacol Sci, 2019 May. PMID 31115012

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of ASF1A and HJURP by global H3-H4 histone chaperone analysis as a prognostic two-gene model in hepatocellular carcinoma.
    Title: Identification of ASF1A and HJURP by global H3-H4 histone chaperone analysis as a prognostic two-gene model in hepatocellular carcinoma.
  2. HJURP is recruited to double-strand break sites and facilitates DNA repair by promoting chromatin reorganization.
    Title: HJURP is recruited to double-strand break sites and facilitates DNA repair by promoting chromatin reorganization.
  3. NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP and participates in the progress of oral squamous cell carcinoma.
    Title: NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP and participates in the progress of oral squamous cell carcinoma.
  4. HJURP inhibits proliferation of ovarian cancer cells by regulating CENP-A/CENP-N.
    Title: HJURP inhibits proliferation of ovarian cancer cells by regulating CENP-A/CENP-N.
  5. HJURP regulates cell proliferation and chemo-resistance via YAP1/NDRG1 transcriptional axis in triple-negative breast cancer.
    Title: HJURP regulates cell proliferation and chemo-resistance via YAP1/NDRG1 transcriptional axis in triple-negative breast cancer.
  6. Holliday junction recognition protein as a prognostic biomarker and therapeutic target for oral cancer.
    Title: Holliday junction recognition protein as a prognostic biomarker and therapeutic target for oral cancer.
  7. Identification of Prognostic Genes for Colon Cancer through Gene Co-expression Network Analysis.
    Title: Identification of Prognostic Genes for Colon Cancer through Gene Co-expression Network Analysis.
  8. HJURP is a prognostic biomarker for clear cell renal cell carcinoma and is linked to immune infiltration.
    Title: HJURP is a prognostic biomarker for clear cell renal cell carcinoma and is linked to immune infiltration.
  9. Hypomethylation-driven overexpression of HJURP promotes progression of hepatocellular carcinoma and is associated with poor prognosis.
    Title: Hypomethylation-driven overexpression of HJURP promotes progression of hepatocellular carcinoma and is associated with poor prognosis.
  10. HJURP promotes proliferation in prostate cancer cells through increasing CDKN1A degradation via the GSK3beta/JNK signaling pathway.
    Title: HJURP promotes proliferation in prostate cancer cells through increasing CDKN1A degradation via the GSK3β/JNK signaling pathway.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp762E1312

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables histone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in CENP-A containing chromatin assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CENP-A containing chromatin assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Holliday junction recognition protein
Names
14-3-3-associated AKT substrate
fetal liver expressing gene 1
fetal liver-expressing gene 1 protein
up-regulated in lung cancer 9

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282962.2 → NP_001269891.1  Holliday junction recognition protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AB101211, AK303109, BM838206, CA441903, CF619091, DB022872, DB319863, DN998761
    Consensus CDS
    CCDS63167.1
    UniProtKB/TrEMBL
    C9JWC4
    Related
    ENSP00000407208.1, ENST00000432087.5
    Conserved Domains (1) summary
    pfam12346
    Location:217 → 331
    HJURP_mid; Holliday junction recognition protein-associated repeat

  2. NM_001282963.2 → NP_001269892.1  Holliday junction recognition protein isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AB101211, AK301643, BM838206, CA441903, CF619091, DB319863, DN998761
    Consensus CDS
    CCDS63166.1
    UniProtKB/TrEMBL
    C9JWC4
    Related
    ENSP00000401944.1, ENST00000441687.5
    Conserved Domains (2) summary
    pfam12346
    Location:186 → 300
    HJURP_mid; Holliday junction recognition protein-associated repeat
    pfam12347
    Location:325 → 383
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  3. NM_018410.5 → NP_060880.3  Holliday junction recognition protein isoform a

    See identical proteins and their annotated locations for NP_060880.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB101211, BM838206, CA441903, CF619091, DB022872, DB319863, DN998761
    Consensus CDS
    CCDS33406.1
    UniProtKB/Swiss-Prot
    A8IRH5, B4DWR0, B4DZV4, Q8NCD3, Q9BUT2, Q9NSL8
    Related
    ENSP00000414109.1, ENST00000411486.7
    Conserved Domains (2) summary
    pfam12346
    Location:271 → 385
    HJURP_mid; Holliday junction recognition protein-associated repeat
    pfam12347
    Location:410 → 468
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    233836702..233854535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444911.1 → XP_047300867.1  Holliday junction recognition protein isoform X1

  2. XM_047444910.1 → XP_047300866.1  Holliday junction recognition protein isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    234325468..234351509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342828.1 → XP_054198803.1  Holliday junction recognition protein isoform X2

  2. XM_054342830.1 → XP_054198805.1  Holliday junction recognition protein isoform X1

  3. XM_054342829.1 → XP_054198804.1  Holliday junction recognition protein isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NCD3.2 GenPept UniProtKB/Swiss-Prot:Q8NCD3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous