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HJURP Holliday junction recognition protein [ Homo sapiens (human) ]

Gene ID: 55355, updated on 6-Jul-2025
Official Symbol
HJURPprovided by HGNC
Official Full Name
Holliday junction recognition proteinprovided by HGNC
Primary source
HGNC:HGNC:25444
See related
Ensembl:ENSG00000123485 MIM:612667; AllianceGenome:HGNC:25444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAKTS; URLC9; hFLEG1
Summary
Enables histone binding activity and identical protein binding activity. Involved in CENP-A containing chromatin assembly; chromosome segregation; and regulation of protein-containing complex assembly. Located in cytosol; kinetochore; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in bone marrow (RPKM 15.6), testis (RPKM 7.0) and 11 other tissues See more
Orthologs
NEW
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See HJURP in Genome Data Viewer
Location:
2q37.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (233836702..233854535, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (234325468..234351509, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (234745348..234763181, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 1 member A complex locus Neighboring gene UDP glucuronosyltransferase family 1 member A8 Neighboring gene UDP glucuronosyltransferase family 1 member A10 Neighboring gene UDP glucuronosyltransferase family 1 member A9 Neighboring gene UDP glucuronosyltransferase family 1 member A7 Neighboring gene UDP glucuronosyltransferase family 1 member A6 Neighboring gene UDP glucuronosyltransferase family 1 member A5 Neighboring gene UDP glucuronosyltransferase family 1 member A4 Neighboring gene UDP glucuronosyltransferase family 1 member A3 Neighboring gene UDP glucuronosyltransferase family 1 member A1 Neighboring gene maestro heat like repeat family member 2A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:234731477-234731977 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:234759038-234759538 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:234763063-234764055 Neighboring gene MSL complex subunit 3B Neighboring gene transient receptor potential cation channel subfamily M member 8 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:234882993-234884192 Neighboring gene Sharpr-MPRA regulatory region 7512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17351 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:234920120-234920398

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • DKFZp762E1312

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
 
enables histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
Holliday junction recognition protein
Names
14-3-3-associated AKT substrate
fetal liver expressing gene 1
fetal liver-expressing gene 1 protein
up-regulated in lung cancer 9

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282962.2NP_001269891.1  Holliday junction recognition protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AB101211, AK303109, BM838206, CA441903, CF619091, DB022872, DB319863, DN998761
    Consensus CDS
    CCDS63167.1
    UniProtKB/TrEMBL
    C9JWC4
    Related
    ENSP00000407208.1, ENST00000432087.5
    Conserved Domains (1) summary
    pfam12346
    Location:217331
    HJURP_mid; Holliday junction recognition protein-associated repeat
  2. NM_001282963.2NP_001269892.1  Holliday junction recognition protein isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AB101211, AK301643, BM838206, CA441903, CF619091, DB319863, DN998761
    Consensus CDS
    CCDS63166.1
    UniProtKB/TrEMBL
    C9JWC4
    Related
    ENSP00000401944.1, ENST00000441687.5
    Conserved Domains (2) summary
    pfam12346
    Location:186300
    HJURP_mid; Holliday junction recognition protein-associated repeat
    pfam12347
    Location:325383
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  3. NM_018410.5NP_060880.3  Holliday junction recognition protein isoform a

    See identical proteins and their annotated locations for NP_060880.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB101211, BM838206, CA441903, CF619091, DB022872, DB319863, DN998761
    Consensus CDS
    CCDS33406.1
    UniProtKB/Swiss-Prot
    A8IRH5, B4DWR0, B4DZV4, Q8NCD3, Q9BUT2, Q9NSL8
    Related
    ENSP00000414109.1, ENST00000411486.7
    Conserved Domains (2) summary
    pfam12346
    Location:271385
    HJURP_mid; Holliday junction recognition protein-associated repeat
    pfam12347
    Location:410468
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    233836702..233854535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444911.1XP_047300867.1  Holliday junction recognition protein isoform X1

  2. XM_047444910.1XP_047300866.1  Holliday junction recognition protein isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    234325468..234351509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342828.1XP_054198803.1  Holliday junction recognition protein isoform X2

  2. XM_054342830.1XP_054198805.1  Holliday junction recognition protein isoform X1

  3. XM_054342829.1XP_054198804.1  Holliday junction recognition protein isoform X1