Format

Send to:

Choose Destination

HJURP Holliday junction recognition protein [ Homo sapiens (human) ]

Gene ID: 55355, updated on 17-Jun-2019

Summary

Official Symbol
HJURPprovided by HGNC
Official Full Name
Holliday junction recognition proteinprovided by HGNC
Primary source
HGNC:HGNC:25444
See related
Ensembl:ENSG00000123485 MIM:612667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAKTS; URLC9; hFLEG1
Expression
Biased expression in bone marrow (RPKM 15.6), testis (RPKM 7.0) and 11 other tissues See more
Orthologs

Genomic context

See HJURP in Genome Data Viewer
Location:
2q37.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (233836701..233854566, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (234745486..234763212, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 1 member A complex locus Neighboring gene UDP glucuronosyltransferase family 1 member A8 Neighboring gene UDP glucuronosyltransferase family 1 member A10 Neighboring gene UDP glucuronosyltransferase family 1 member A9 Neighboring gene UDP glucuronosyltransferase family 1 member A7 Neighboring gene UDP glucuronosyltransferase family 1 member A6 Neighboring gene UDP glucuronosyltransferase family 1 member A5 Neighboring gene UDP glucuronosyltransferase family 1 member A4 Neighboring gene UDP glucuronosyltransferase family 1 member A3 Neighboring gene UDP glucuronosyltransferase family 1 member A1 Neighboring gene maestro heat like repeat family member 2A Neighboring gene MSL complex subunit 3 pseudogene 1 Neighboring gene transient receptor potential cation channel subfamily M member 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp762E1312

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CENP-A containing nucleosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
Holliday junction recognition protein
Names
14-3-3-associated AKT substrate
fetal liver expressing gene 1
fetal liver-expressing gene 1 protein
up-regulated in lung cancer 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282962.1NP_001269891.1  Holliday junction recognition protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AB101211, AK303109, BM838206, CA441903, CF619091, DB022872, DB319863, DN998761
    Consensus CDS
    CCDS63167.1
    UniProtKB/Swiss-Prot
    Q8NCD3
    Related
    ENSP00000407208.1, ENST00000432087.5
    Conserved Domains (2) summary
    pfam12346
    Location:217331
    HJURP_mid; Holliday junction recognition protein-associated repeat
    pfam12347
    Location:356414
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  2. NM_001282963.1NP_001269892.1  Holliday junction recognition protein isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AB101211, AK301643, BM838206, CA441903, CF619091, DB319863, DN998761
    Consensus CDS
    CCDS63166.1
    UniProtKB/Swiss-Prot
    Q8NCD3
    Related
    ENSP00000401944.1, ENST00000441687.5
    Conserved Domains (2) summary
    pfam12346
    Location:186300
    HJURP_mid; Holliday junction recognition protein-associated repeat
    pfam12347
    Location:325383
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  3. NM_018410.5NP_060880.3  Holliday junction recognition protein isoform a

    See identical proteins and their annotated locations for NP_060880.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB101211, BM838206, CA441903, CF619091, DB022872, DB319863, DN998761
    Consensus CDS
    CCDS33406.1
    UniProtKB/Swiss-Prot
    Q8NCD3
    Related
    ENSP00000414109.1, ENST00000411486.7
    Conserved Domains (2) summary
    pfam12346
    Location:271385
    HJURP_mid; Holliday junction recognition protein-associated repeat
    pfam12347
    Location:410468
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    233836701..233854566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511437.1XP_011509739.1  Holliday junction recognition protein isoform X1

    Conserved Domains (2) summary
    pfam12346
    Location:159273
    HJURP_mid; Holliday junction recognition protein-associated repeat
    pfam12347
    Location:298356
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
Support Center