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STK32B serine/threonine kinase 32B [ Homo sapiens (human) ]

Gene ID: 55351, updated on 28-Sep-2022

Summary

Official Symbol
STK32Bprovided by HGNC
Official Full Name
serine/threonine kinase 32Bprovided by HGNC
Primary source
HGNC:HGNC:14217
See related
Ensembl:ENSG00000152953 AllianceGenome:HGNC:14217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STK32; STKG6; YANK2; HSA250839
Summary
This gene encodes a serine-threonine protein kinase. Serine-threonine kinases transfer phosphate molecules to the oxygen atoms of serine and threonine. A genomic deletion affecting this gene has been associated with Ellis-van Creveld syndrome, an autosomal recessive skeletal dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Expression
Broad expression in kidney (RPKM 2.0), testis (RPKM 1.4) and 14 other tissues See more
Orthologs
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Genomic context

See STK32B in Genome Data Viewer
Location:
4p16.2
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (5019386..5500989)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (5021125..5470430)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (5053207..5502716)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928306 Neighboring gene uncharacterized LOC107986218 Neighboring gene RN7SK pseudogene 113 Neighboring gene uncharacterized LOC107986256 Neighboring gene cytokine like 1 Neighboring gene Sharpr-MPRA regulatory region 6927 Neighboring gene Sharpr-MPRA regulatory region 9083 Neighboring gene RN7SK pseudogene 275 Neighboring gene uncharacterized LOC124900166 Neighboring gene long intergenic non-protein coding RNA 1587 Neighboring gene EvC ciliary complex subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
EBI GWAS Catalog
Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae.
EBI GWAS Catalog
Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy.
EBI GWAS Catalog
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
EBI GWAS Catalog
Two-marker association tests yield new disease associations for coronary artery disease and hypertension.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 32B
Names
gene for serine/threonine protein kinase
yet another novel kinase 2
NP_001293011.1
NP_001332898.1
NP_060871.1
XP_024309899.1
XP_047271880.1
XP_047271881.1
XP_047271882.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051593.2 RefSeqGene

    Range
    37096..486605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306082.2NP_001293011.1  serine/threonine-protein kinase 32B isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004664, AC096740, AJ250839, AK313846, BC069203
    Consensus CDS
    CCDS77895.1
    UniProtKB/Swiss-Prot
    Q9NY57
    UniProtKB/TrEMBL
    B2R9M8
    Conserved Domains (1) summary
    cd05578
    Location:1236
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  2. NM_001345969.2NP_001332898.1  serine/threonine-protein kinase 32B isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC004664, AC092665, AC096740
    Conserved Domains (2) summary
    smart00220
    Location:23240
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:22253
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  3. NM_018401.3NP_060871.1  serine/threonine-protein kinase 32B isoform 1

    See identical proteins and their annotated locations for NP_060871.1

    Status: REVIEWED

    Source sequence(s)
    AC004664, AC096740, AJ250839, AK313846, BC069203
    Consensus CDS
    CCDS3380.1
    UniProtKB/Swiss-Prot
    Q8IY14, Q9NY57
    UniProtKB/TrEMBL
    B2R9M8
    Related
    ENSP00000282908.5, ENST00000282908.10
    Conserved Domains (2) summary
    smart00220
    Location:23270
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:22283
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    5019386..5500989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415924.1XP_047271880.1  serine/threonine-protein kinase 32B isoform X1

  2. XM_047415925.1XP_047271881.1  serine/threonine-protein kinase 32B isoform X2

  3. XM_047415926.1XP_047271882.1  serine/threonine-protein kinase 32B isoform X3

  4. XM_024454131.2XP_024309899.1  serine/threonine-protein kinase 32B isoform X3

    Related
    ENSP00000420984.1, ENST00000510398.1
    Conserved Domains (1) summary
    cd05578
    Location:1236
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    5021125..5470430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)