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top1l DNA topoisomerase I, like [ Danio rerio (zebrafish) ]

Gene ID: 553496, updated on 1-Aug-2018

Summary

Official Symbol
top1lprovided by ZNC
Official Full Name
DNA topoisomerase I, likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060616-217
See related
Ensembl:ENSDARG00000070545 Vega:OTTDARG00000022487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
Also known as
wu:fc66a02; zgc:136349
Orthologs

Genomic context

See top1l in Genome Data Viewer
Location:
chromosome: 11
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (25296366..25311680)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (25058750..25074064)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene tumor protein p53 inducible nuclear protein 2 Neighboring gene cylindromatosis (turban tumor syndrome), b Neighboring gene si:ch211-232b12.5 Neighboring gene family with sequence similarity 83, member D

Genomic regions, transcripts, and products

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA topoisomerase type I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topoisomerase type I activity IEA
Inferred from Electronic Annotation
more info
 
isomerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topological change IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topological change IEA
Inferred from Electronic Annotation
more info
 
chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DNA topoisomerase 1
Names
topoisomerase (DNA) I, like
NP_001037789.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044324.2NP_001037789.1  DNA topoisomerase 1

    See identical proteins and their annotated locations for NP_001037789.1

    Status: VALIDATED

    Source sequence(s)
    BC050952, BC117588, CR548630
    UniProtKB/TrEMBL
    Q1ED17
    Related
    ENSDARP00000065948.6, OTTDARP00000023684, ENSDART00000065949.8, OTTDART00000028960
    Conserved Domains (4) summary
    smart00435
    Location:353730
    TOPEUc; DNA Topoisomerase I (eukaryota)
    pfam01028
    Location:425628
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam02919
    Location:208422
    Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
    pfam14370
    Location:688756
    Topo_C_assoc; C-terminal topoisomerase domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    25296366..25311680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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