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ABHD10 abhydrolase domain containing 10, depalmitoylase [ Homo sapiens (human) ]

Gene ID: 55347, updated on 1-Jun-2020

Summary

Official Symbol
ABHD10provided by HGNC
Official Full Name
abhydrolase domain containing 10, depalmitoylaseprovided by HGNC
Primary source
HGNC:HGNC:25656
See related
Ensembl:ENSG00000144827 MIM:618756
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in kidney (RPKM 20.6), thyroid (RPKM 19.7) and 25 other tissues See more
Orthologs

Genomic context

See ABHD10 in Genome Data Viewer
Location:
3q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (111979026..111993368)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (111697723..111712215)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol specific phospholipase C X domain containing 2 Neighboring gene pleckstrin homology like domain family B member 2 Neighboring gene uncharacterized LOC107984087 Neighboring gene uncharacterized LOC105374040 Neighboring gene transgelin 3 Neighboring gene riboflavin kinase pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11342, FLJ36272

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular glucuronidation TAS
Traceable Author Statement
more info
 
glucuronoside catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
mycophenolic acid acyl-glucuronide esterase, mitochondrial
Names
abhydrolase domain containing 10
abhydrolase domain-containing protein 10, mitochondrial
alpha/beta hydrolase domain-containing protein 10, mitochondrial
NP_001258998.1
NP_060864.1
XP_011511262.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272069.2NP_001258998.1  mycophenolic acid acyl-glucuronide esterase, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001258998.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL713726, CA427297, DB453330, DR760607
    Consensus CDS
    CCDS63718.1
    UniProtKB/Swiss-Prot
    Q9NUJ1
    Related
    ENSP00000418973.1, ENST00000494817.1
    Conserved Domains (1) summary
    COG0596
    Location:65180
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
  2. NM_018394.4NP_060864.1  mycophenolic acid acyl-glucuronide esterase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_060864.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL713726, BC014516, CA427297, DB453330
    Consensus CDS
    CCDS2963.1
    UniProtKB/Swiss-Prot
    Q9NUJ1
    Related
    ENSP00000273359.3, ENST00000273359.8
    Conserved Domains (1) summary
    COG0596
    Location:65291
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RNA

  1. NR_073570.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK300018, AL713726, CA427297
  2. NR_073571.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK300018, AL713726, CA427297, DB453330, DB494690

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    111979026..111993368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512960.3XP_011511262.1  mycophenolic acid acyl-glucuronide esterase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011511262.1

    UniProtKB/Swiss-Prot
    Q9NUJ1
    Conserved Domains (1) summary
    COG0596
    Location:65180
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
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