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ZGRF1 zinc finger GRF-type containing 1 [ Homo sapiens (human) ]

Gene ID: 55345, updated on 4-Feb-2024

Summary

Official Symbol
ZGRF1provided by HGNC
Official Full Name
zinc finger GRF-type containing 1provided by HGNC
Primary source
HGNC:HGNC:25654
See related
Ensembl:ENSG00000138658 AllianceGenome:HGNC:25654
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C4orf21
Summary
The encoded protein contains GRF zinc finger (zf-GRF) and transmembrane domains. GRF zinc fingers are found in a number of DNA-binding proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2017]
Expression
Broad expression in bone marrow (RPKM 3.0), testis (RPKM 2.5) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZGRF1 in Genome Data Viewer
Location:
4q25
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (112539339..112636909, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (115847675..115945477, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (113460495..113558065, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15640 Neighboring gene uncharacterized LOC124900760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:113438107-113438987 Neighboring gene NEUROG2 and ZGRF1 antisense RNA 1 Neighboring gene VISTA enhancer hs981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15641 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15642 Neighboring gene ribosomal protein L23a pseudogene 94 Neighboring gene H3 histone pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21832 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21833 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:113564861-113564962 Neighboring gene La ribonucleoprotein 7, transcriptional regulator Neighboring gene miR-302/367 cluster host gene Neighboring gene microRNA 302d Neighboring gene microRNA 367

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study on thyroid function and anti-thyroid peroxidase antibodies in Koreans.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ11331, FLJ33237, FLJ44066, DKFZp313L226, DKFZp434C0927

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 5'-3' DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in recombinational repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in recombinational repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
5'-3' DNA helicase ZGRF1; protein ZGRF1
Names
GRF-type zinc finger domain-containing protein 1
NP_001337326.1
NP_060862.3
XP_005263172.1
XP_011530393.1
XP_011530394.1
XP_011530396.1
XP_011530398.1
XP_011530399.1
XP_011530400.1
XP_011530401.1
XP_016863858.1
XP_016863859.1
XP_047271865.1
XP_047271866.1
XP_047271867.1
XP_047271868.1
XP_047271869.1
XP_047271870.1
XP_047271871.1
XP_047271872.1
XP_047271873.1
XP_047271874.1
XP_047271875.1
XP_047271876.1
XP_047271877.1
XP_047271878.1
XP_047271879.1
XP_054206389.1
XP_054206390.1
XP_054206391.1
XP_054206392.1
XP_054206393.1
XP_054206394.1
XP_054206395.1
XP_054206396.1
XP_054206397.1
XP_054206398.1
XP_054206399.1
XP_054206400.1
XP_054206401.1
XP_054206402.1
XP_054206403.1
XP_054206404.1
XP_054206405.1
XP_054206406.1
XP_054206407.1
XP_054206408.1
XP_054206409.1
XP_054206410.1
XP_054206411.1
XP_054206412.1
XP_054206413.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053121.1 RefSeqGene

    Range
    5087..102657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001350397.2NP_001337326.1  5'-3' DNA helicase ZGRF1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC023886
    Conserved Domains (4) summary
    pfam06839
    Location:12891333
    zf-GRF; GRF zinc finger
    pfam10382
    Location:473
    DUF2439; Protein of unknown function (DUF2439)
    pfam13087
    Location:17971981
    AAA_12; AAA domain
    cl26261
    Location:15912003
    AAA_11; AAA domain
  2. NM_018392.5NP_060862.3  5'-3' DNA helicase ZGRF1 isoform 1

    See identical proteins and their annotated locations for NP_060862.3

    Status: REVIEWED

    Source sequence(s)
    AK126054, AK299831, AL708767, BC044799, BF056790, BM721145, CN297341, DA199760
    Consensus CDS
    CCDS3700.2
    UniProtKB/Swiss-Prot
    B3KQX2, B4DSN6, B4DYU8, E9PDE1, G5EA02, Q6ZU11, Q86YA3, Q9NSW3, Q9NUJ4
    Related
    ENSP00000424737.1, ENST00000505019.6
    Conserved Domains (5) summary
    COG1112
    Location:17392057
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:13471391
    zf-GRF; GRF zinc finger
    pfam10382
    Location:473
    DUF2439; Protein of unknown function (DUF2439)
    pfam13086
    Location:16141844
    AAA_11; AAA domain
    pfam13087
    Location:18552039
    AAA_12; AAA domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    112539339..112636909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415917.1XP_047271873.1  protein ZGRF1 isoform X10

  2. XM_047415914.1XP_047271870.1  protein ZGRF1 isoform X7

  3. XM_011532092.3XP_011530394.1  protein ZGRF1 isoform X3

    Conserved Domains (5) summary
    COG1112
    Location:17192037
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:13271371
    zf-GRF; GRF zinc finger
    pfam10382
    Location:453
    DUF2439; Protein of unknown function (DUF2439)
    pfam13086
    Location:15941824
    AAA_11; AAA domain
    pfam13087
    Location:18352019
    AAA_12; AAA domain
  4. XM_017008370.2XP_016863859.1  protein ZGRF1 isoform X6

  5. XM_011532091.3XP_011530393.1  protein ZGRF1 isoform X2

    Conserved Domains (5) summary
    COG1112
    Location:17222040
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:13301374
    zf-GRF; GRF zinc finger
    pfam10382
    Location:473
    DUF2439; Protein of unknown function (DUF2439)
    pfam13086
    Location:15971827
    AAA_11; AAA domain
    pfam13087
    Location:18382022
    AAA_12; AAA domain
  6. XM_011532094.3XP_011530396.1  protein ZGRF1 isoform X8

    Conserved Domains (5) summary
    COG1112
    Location:16531971
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:12611305
    zf-GRF; GRF zinc finger
    pfam10382
    Location:473
    DUF2439; Protein of unknown function (DUF2439)
    pfam13086
    Location:15281758
    AAA_11; AAA domain
    pfam13087
    Location:17691953
    AAA_12; AAA domain
  7. XM_047415916.1XP_047271872.1  protein ZGRF1 isoform X9

  8. XM_047415910.1XP_047271866.1  protein ZGRF1 isoform X4

  9. XM_047415918.1XP_047271874.1  protein ZGRF1 isoform X10

  10. XM_047415913.1XP_047271869.1  protein ZGRF1 isoform X7

  11. XM_017008369.3XP_016863858.1  protein ZGRF1 isoform X3

    Conserved Domains (5) summary
    COG1112
    Location:17192037
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:13271371
    zf-GRF; GRF zinc finger
    pfam10382
    Location:453
    DUF2439; Protein of unknown function (DUF2439)
    pfam13086
    Location:15941824
    AAA_11; AAA domain
    pfam13087
    Location:18352019
    AAA_12; AAA domain
  12. XM_047415912.1XP_047271868.1  protein ZGRF1 isoform X6

  13. XM_047415909.1XP_047271865.1  protein ZGRF1 isoform X2

  14. XM_047415915.1XP_047271871.1  protein ZGRF1 isoform X8

  15. XM_047415911.1XP_047271867.1  protein ZGRF1 isoform X5

  16. XM_005263115.5XP_005263172.1  protein ZGRF1 isoform X1

    See identical proteins and their annotated locations for XP_005263172.1

    UniProtKB/Swiss-Prot
    B3KQX2, B4DSN6, B4DYU8, E9PDE1, G5EA02, Q6ZU11, Q86YA3, Q9NSW3, Q9NUJ4
    Conserved Domains (5) summary
    COG1112
    Location:17392057
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:13471391
    zf-GRF; GRF zinc finger
    pfam10382
    Location:473
    DUF2439; Protein of unknown function (DUF2439)
    pfam13086
    Location:16141844
    AAA_11; AAA domain
    pfam13087
    Location:18552039
    AAA_12; AAA domain
  17. XM_047415919.1XP_047271875.1  protein ZGRF1 isoform X11

  18. XM_011532097.3XP_011530399.1  protein ZGRF1 isoform X16

    Conserved Domains (4) summary
    COG1112
    Location:7881106
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:396440
    zf-GRF; GRF zinc finger
    pfam13086
    Location:663893
    AAA_11; AAA domain
    pfam13087
    Location:9041088
    AAA_12; AAA domain
  19. XM_011532098.3XP_011530400.1  protein ZGRF1 isoform X18

    See identical proteins and their annotated locations for XP_011530400.1

    Conserved Domains (4) summary
    COG1112
    Location:6961014
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:304348
    zf-GRF; GRF zinc finger
    pfam13086
    Location:571801
    AAA_11; AAA domain
    pfam13087
    Location:812996
    AAA_12; AAA domain
  20. XM_011532099.3XP_011530401.1  protein ZGRF1 isoform X18

    See identical proteins and their annotated locations for XP_011530401.1

    Conserved Domains (4) summary
    COG1112
    Location:6961014
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:304348
    zf-GRF; GRF zinc finger
    pfam13086
    Location:571801
    AAA_11; AAA domain
    pfam13087
    Location:812996
    AAA_12; AAA domain
  21. XM_047415921.1XP_047271877.1  protein ZGRF1 isoform X13

  22. XM_047415920.1XP_047271876.1  protein ZGRF1 isoform X12

  23. XM_011532096.3XP_011530398.1  protein ZGRF1 isoform X14

    Conserved Domains (2) summary
    pfam06839
    Location:13471391
    zf-GRF; GRF zinc finger
    pfam10382
    Location:473
    DUF2439; Protein of unknown function (DUF2439)
  24. XM_047415922.1XP_047271878.1  protein ZGRF1 isoform X15

  25. XM_047415923.1XP_047271879.1  protein ZGRF1 isoform X17

    UniProtKB/TrEMBL
    G3XAL8
    Related
    ENSP00000309095.5, ENST00000309071.9

RNA

  1. XR_938764.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    115847675..115945477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350420.1XP_054206395.1  protein ZGRF1 isoform X5

  2. XM_054350427.1XP_054206402.1  protein ZGRF1 isoform X9

  3. XM_054350419.1XP_054206394.1  protein ZGRF1 isoform X4

  4. XM_054350429.1XP_054206404.1  protein ZGRF1 isoform X10

  5. XM_054350423.1XP_054206398.1  protein ZGRF1 isoform X7

  6. XM_054350417.1XP_054206392.1  protein ZGRF1 isoform X3

  7. XM_054350422.1XP_054206397.1  protein ZGRF1 isoform X6

  8. XM_054350415.1XP_054206390.1  protein ZGRF1 isoform X2

  9. XM_054350426.1XP_054206401.1  protein ZGRF1 isoform X8

  10. XM_054350414.1XP_054206389.1  protein ZGRF1 isoform X1

    UniProtKB/Swiss-Prot
    B3KQX2, B4DSN6, B4DYU8, E9PDE1, G5EA02, Q6ZU11, Q86YA3, Q9NSW3, Q9NUJ4
  11. XM_054350428.1XP_054206403.1  protein ZGRF1 isoform X10

  12. XM_054350424.1XP_054206399.1  protein ZGRF1 isoform X7

  13. XM_054350418.1XP_054206393.1  protein ZGRF1 isoform X3

  14. XM_054350421.1XP_054206396.1  protein ZGRF1 isoform X6

  15. XM_054350416.1XP_054206391.1  protein ZGRF1 isoform X2

  16. XM_054350425.1XP_054206400.1  protein ZGRF1 isoform X8

  17. XM_054350430.1XP_054206405.1  protein ZGRF1 isoform X11

  18. XM_054350435.1XP_054206410.1  protein ZGRF1 isoform X16

  19. XM_054350437.1XP_054206412.1  protein ZGRF1 isoform X18

  20. XM_054350438.1XP_054206413.1  protein ZGRF1 isoform X18

  21. XM_054350432.1XP_054206407.1  protein ZGRF1 isoform X13

  22. XM_054350431.1XP_054206406.1  protein ZGRF1 isoform X12

  23. XM_054350434.1XP_054206409.1  protein ZGRF1 isoform X15

  24. XM_054350433.1XP_054206408.1  protein ZGRF1 isoform X14

  25. XM_054350436.1XP_054206411.1  protein ZGRF1 isoform X17

    UniProtKB/TrEMBL
    G3XAL8

RNA

  1. XR_008487015.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099776.1: Suppressed sequence

    Description
    NM_001099776.1: This RefSeq was permanently suppressed because the CDS was partial.
  2. NM_138698.2: Suppressed sequence

    Description
    NM_138698.2: This RefSeq was permanently suppressed because the CDS was partial.