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ZGRF1 zinc finger GRF-type containing 1 [ Homo sapiens (human) ]

Gene ID: 55345, updated on 23-Nov-2021

Summary

Official Symbol
ZGRF1provided by HGNC
Official Full Name
zinc finger GRF-type containing 1provided by HGNC
Primary source
HGNC:HGNC:25654
See related
Ensembl:ENSG00000138658
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C4orf21
Summary
The encoded protein contains GRF zinc finger (zf-GRF) and transmembrane domains. GRF zinc fingers are found in a number of DNA-binding proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2017]
Expression
Broad expression in bone marrow (RPKM 3.0), testis (RPKM 2.5) and 24 other tissues See more
Orthologs
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Genomic context

See ZGRF1 in Genome Data Viewer
Location:
4q25
Exon count:
31
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (112539339..112636995, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (113460495..113558065, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NEUROG2 and ZGRF1 antisense RNA 1 Neighboring gene VISTA enhancer hs981 Neighboring gene ribosomal protein L23a pseudogene 94 Neighboring gene H3 histone pseudogene 14 Neighboring gene La ribonucleoprotein 7, transcriptional regulator Neighboring gene miR-302/367 cluster host gene Neighboring gene microRNA 302d Neighboring gene microRNA 367

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study on thyroid function and anti-thyroid peroxidase antibodies in Koreans.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11331, FLJ33237, FLJ44066, DKFZp313L226, DKFZp434C0927

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 5'-flap endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in replication fork reversal IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein ZGRF1
Names
GRF-type zinc finger domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053121.1 RefSeqGene

    Range
    5001..102663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001350397.2NP_001337326.1  protein ZGRF1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC023886
    Conserved Domains (4) summary
    pfam06839
    Location:12891333
    zf-GRF; GRF zinc finger
    pfam10382
    Location:473
    DUF2439; Protein of unknown function (DUF2439)
    pfam13087
    Location:17971981
    AAA_12; AAA domain
    cl26261
    Location:15912003
    AAA_11; AAA domain
  2. NM_018392.5NP_060862.3  protein ZGRF1 isoform 1

    See identical proteins and their annotated locations for NP_060862.3

    Status: REVIEWED

    Source sequence(s)
    AK126054, AK299831, AL708767, BC044799, BF056790, BM721145, CN297341, DA199760
    Consensus CDS
    CCDS3700.2
    UniProtKB/Swiss-Prot
    Q86YA3
    Related
    ENSP00000424737.1, ENST00000505019.6
    Conserved Domains (5) summary
    COG1112
    Location:17392057
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:13471391
    zf-GRF; GRF zinc finger
    pfam10382
    Location:473
    DUF2439; Protein of unknown function (DUF2439)
    pfam13086
    Location:16141844
    AAA_11; AAA domain
    pfam13087
    Location:18552039
    AAA_12; AAA domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    112539339..112636995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008370.1XP_016863859.1  protein ZGRF1 isoform X4

  2. XM_011532091.2XP_011530393.1  protein ZGRF1 isoform X2

    Conserved Domains (5) summary
    COG1112
    Location:17222040
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:13301374
    zf-GRF; GRF zinc finger
    pfam10382
    Location:473
    DUF2439; Protein of unknown function (DUF2439)
    pfam13086
    Location:15971827
    AAA_11; AAA domain
    pfam13087
    Location:18382022
    AAA_12; AAA domain
  3. XM_011532094.2XP_011530396.1  protein ZGRF1 isoform X5

    Conserved Domains (5) summary
    COG1112
    Location:16531971
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:12611305
    zf-GRF; GRF zinc finger
    pfam10382
    Location:473
    DUF2439; Protein of unknown function (DUF2439)
    pfam13086
    Location:15281758
    AAA_11; AAA domain
    pfam13087
    Location:17691953
    AAA_12; AAA domain
  4. XM_017008371.1XP_016863860.1  protein ZGRF1 isoform X6

  5. XM_011532092.2XP_011530394.1  protein ZGRF1 isoform X3

    Conserved Domains (5) summary
    COG1112
    Location:17192037
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:13271371
    zf-GRF; GRF zinc finger
    pfam10382
    Location:453
    DUF2439; Protein of unknown function (DUF2439)
    pfam13086
    Location:15941824
    AAA_11; AAA domain
    pfam13087
    Location:18352019
    AAA_12; AAA domain
  6. XM_017008372.1XP_016863861.1  protein ZGRF1 isoform X10

    Conserved Domains (3) summary
    pfam06839
    Location:97141
    zf-GRF; GRF zinc finger
    pfam13087
    Location:605789
    AAA_12; AAA domain
    cl26261
    Location:399811
    AAA_11; AAA domain
  7. XM_017008373.1XP_016863862.1  protein ZGRF1 isoform X10

    Conserved Domains (3) summary
    pfam06839
    Location:97141
    zf-GRF; GRF zinc finger
    pfam13087
    Location:605789
    AAA_12; AAA domain
    cl26261
    Location:399811
    AAA_11; AAA domain
  8. XM_005263115.4XP_005263172.1  protein ZGRF1 isoform X1

    See identical proteins and their annotated locations for XP_005263172.1

    UniProtKB/Swiss-Prot
    Q86YA3
    Conserved Domains (5) summary
    COG1112
    Location:17392057
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:13471391
    zf-GRF; GRF zinc finger
    pfam10382
    Location:473
    DUF2439; Protein of unknown function (DUF2439)
    pfam13086
    Location:16141844
    AAA_11; AAA domain
    pfam13087
    Location:18552039
    AAA_12; AAA domain
  9. XM_017008369.2XP_016863858.1  protein ZGRF1 isoform X3

    Conserved Domains (5) summary
    COG1112
    Location:17192037
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:13271371
    zf-GRF; GRF zinc finger
    pfam10382
    Location:453
    DUF2439; Protein of unknown function (DUF2439)
    pfam13086
    Location:15941824
    AAA_11; AAA domain
    pfam13087
    Location:18352019
    AAA_12; AAA domain
  10. XM_024454130.1XP_024309898.1  protein ZGRF1 isoform X10

    Conserved Domains (3) summary
    pfam06839
    Location:97141
    zf-GRF; GRF zinc finger
    pfam13087
    Location:605789
    AAA_12; AAA domain
    cl26261
    Location:399811
    AAA_11; AAA domain
  11. XM_024454129.1XP_024309897.1  protein ZGRF1 isoform X10

    Conserved Domains (3) summary
    pfam06839
    Location:97141
    zf-GRF; GRF zinc finger
    pfam13087
    Location:605789
    AAA_12; AAA domain
    cl26261
    Location:399811
    AAA_11; AAA domain
  12. XM_011532097.2XP_011530399.1  protein ZGRF1 isoform X8

    Conserved Domains (4) summary
    COG1112
    Location:7881106
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:396440
    zf-GRF; GRF zinc finger
    pfam13086
    Location:663893
    AAA_11; AAA domain
    pfam13087
    Location:9041088
    AAA_12; AAA domain
  13. XM_011532098.2XP_011530400.1  protein ZGRF1 isoform X9

    See identical proteins and their annotated locations for XP_011530400.1

    Conserved Domains (4) summary
    COG1112
    Location:6961014
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:304348
    zf-GRF; GRF zinc finger
    pfam13086
    Location:571801
    AAA_11; AAA domain
    pfam13087
    Location:812996
    AAA_12; AAA domain
  14. XM_011532099.2XP_011530401.1  protein ZGRF1 isoform X9

    See identical proteins and their annotated locations for XP_011530401.1

    Conserved Domains (4) summary
    COG1112
    Location:6961014
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:304348
    zf-GRF; GRF zinc finger
    pfam13086
    Location:571801
    AAA_11; AAA domain
    pfam13087
    Location:812996
    AAA_12; AAA domain
  15. XM_011532096.2XP_011530398.1  protein ZGRF1 isoform X7

    Conserved Domains (2) summary
    pfam06839
    Location:13471391
    zf-GRF; GRF zinc finger
    pfam10382
    Location:473
    DUF2439; Protein of unknown function (DUF2439)

RNA

  1. XR_001741282.1 RNA Sequence

  2. XR_938763.1 RNA Sequence

  3. XR_938764.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099776.1: Suppressed sequence

    Description
    NM_001099776.1: This RefSeq was permanently suppressed because the CDS was partial.
  2. NM_138698.2: Suppressed sequence

    Description
    NM_138698.2: This RefSeq was permanently suppressed because the CDS was partial.
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