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PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 [ Homo sapiens (human) ]

Gene ID: 55344, updated on 18-Aug-2020

Summary

Official Symbol
PLCXD1provided by HGNC
Official Full Name
phosphatidylinositol specific phospholipase C X domain containing 1provided by HGNC
Primary source
HGNC:HGNC:23148
See related
Ensembl:ENSG00000182378 MIM:300974
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LL0XNC01-136G2.1
Summary
This gene is the most terminal protein-coding gene in the pseudoautosomal (PAR) region on chromosomes X and Y. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in stomach (RPKM 5.3), skin (RPKM 4.4) and 25 other tissues See more
Orthologs

Genomic context

See PLCXD1 in Genome Data Viewer
Location:
Xp22.33 and Yp11.32
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (276356..303356)
109.20200815 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (276356..303356)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (192991..220023)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (142991..170023)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene GTP binding protein 6 (putative) Neighboring gene long intergenic non-protein coding RNA 685 Neighboring gene protein phosphatase 2 regulatory subunit B''beta

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene GTP binding protein 6 (putative) Neighboring gene long intergenic non-protein coding RNA 685 Neighboring gene protein phosphatase 2 regulatory subunit B''beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11323

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PI-PLC X domain-containing protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016868.1 RefSeqGene

    Range
    10058..32033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001370370.1NP_001357299.1  PI-PLC X domain-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX000483, BX537334
    Related
    ENSP00000381976.1, ENST00000399012.6
    Conserved Domains (1) summary
    cd08616
    Location:27317
    PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1
  2. NM_001370371.1NP_001357300.1  PI-PLC X domain-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX000483, BX537334
    Conserved Domains (1) summary
    cd08616
    Location:27317
    PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1
  3. NM_001370372.1NP_001357301.1  PI-PLC X domain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    BX000483, BX537334
    Conserved Domains (1) summary
    cd08616
    Location:27265
    PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1
  4. NM_001370373.1NP_001357302.1  PI-PLC X domain-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX000483, BX537334
    Conserved Domains (1) summary
    cd08616
    Location:27317
    PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1
  5. NM_018390.4NP_060860.1  PI-PLC X domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_060860.1

    Status: REVIEWED

    Source sequence(s)
    BC005028, BU594555, BX000483, BX537334, DA052662
    Consensus CDS
    CCDS14103.1
    UniProtKB/Swiss-Prot
    Q9NUJ7
    Related
    ENSP00000371073.2, ENST00000381657.8
    Conserved Domains (1) summary
    cd08616
    Location:27317
    PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1

RNA

  1. NR_028057.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BX000483, BX537334
  2. NR_163416.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BX000483, BX537334

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    276356..303356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011546180.3XP_011544482.1  PI-PLC X domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011544482.1

    UniProtKB/Swiss-Prot
    Q9NUJ7
    Related
    ENSP00000371079.3, ENST00000381663.8
    Conserved Domains (1) summary
    cd08616
    Location:27317
    PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1
  2. XM_024452395.1XP_024308163.1  PI-PLC X domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    cd08616
    Location:27317
    PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    276356..303356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545633.3XP_011543935.1  PI-PLC X domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543935.1

    UniProtKB/Swiss-Prot
    Q9NUJ7
    Conserved Domains (1) summary
    cd08616
    Location:27317
    PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1
  2. XM_024452491.1XP_024308259.1  PI-PLC X domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    cd08616
    Location:27317
    PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1
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