U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

kif6 kinesin family member 6 [ Danio rerio (zebrafish) ]

Gene ID: 553436, updated on 27-Sep-2025
Official Symbol
kif6provided by ZNC
Official Full Name
kinesin family member 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-061027-130
See related
Ensembl:ENSDARG00000053240 Ensembl:ENSDARG00000105453 AllianceGenome:ZFIN:ZDB-GENE-061027-130
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:152746
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within spinal cord development. Located in ciliary base. Is expressed in brain; intestine; ovary; and testis. Used to study idiopathic scoliosis. Human ortholog(s) of this gene implicated in artery disease (multiple) and type 2 diabetes mellitus. Orthologous to human KIF6 (kinesin family member 6). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See kif6 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 17 NC_133192.1 (54759090..54828981, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 17 NC_007128.7 (48745738..48805127, complement)

Chromosome 17 - NC_133192.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141378404 Neighboring gene uncharacterized LOC141378388 Neighboring gene potassium channel, subfamily K, member 5a Neighboring gene dishevelled associated activator of morphogenesis 2 Neighboring gene galectin 8b

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Identification and functional characterization of zebrafish K(2P)17.1 (TASK-4, TALK-2) two-pore-domain K(+) channels. Staudacher I, et al. Eur J Pharmacol, 2018 Jul 15. PMID 29753045
  2. Postembryonic screen for mutations affecting spine development in zebrafish. Gray RS, et al. Dev Biol, 2021 Mar. PMID 33290818, Free PMC Article
  3. Understanding Idiopathic Scoliosis: A New Zebrafish School of Thought. Boswell CW, et al. Trends Genet, 2017 Mar. PMID 28174019
  4. Kinesin family member 6 (kif6) is necessary for spine development in zebrafish. Buchan JG, et al. Dev Dyn, 2014 Dec. PMID 25283277, Free PMC Article
  5. Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development. Konjikusic MJ, et al. PLoS Genet, 2018 Nov. PMID 30475797, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spinal cord development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in ciliary base IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
kinesin-like protein KIF6
Names
skolios
zmp:0000001165

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001423671.2 → NP_001410600.1  kinesin-like protein KIF6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000017
    UniProtKB/TrEMBL
    A0AB13A9F9, A0AB32T5K2
    Related
    ENSDARP00000094438.4, ENSDART00000103662.6

  2. NM_001443234.2 → NP_001430163.2  kinesin-like protein KIF6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000017

RNA

  1. NR_200082.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000017

  2. NR_200083.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000017

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133192.1 Reference GRCz12tu Primary Assembly

    Range
    54759090..54828981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073927282.1 → XP_073783383.1  kinesin-like protein KIF6 isoform X1

    UniProtKB/TrEMBL
    A0AB32T5K2

  2. XM_073927284.1 → XP_073783385.1  kinesin-like protein KIF6 isoform X2

    UniProtKB/TrEMBL
    A0AB32T5K2

RNA

  1. XR_012392734.1 RNA Sequence

  2. XR_012392731.1 RNA Sequence

  3. XR_012392736.1 RNA Sequence

  4. XR_012392735.1 RNA Sequence

  5. XR_012392733.1 RNA Sequence

  6. XR_012392732.1 RNA Sequence

  7. XR_012392737.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001077431.1: Suppressed sequence

    Description
    NM_001077431.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools